Non-coding cis-element of Period2 is essential for maintaining organismal circadian behaviour and body temperature rhythmicity

The circadian transcription factors BMAL1:CLOCK bind to E/E′-boxes in gene regulatory elements of their targets and facilitate rhythmic expression. Here, the authors mutate the Per2 promoter E’′-box in mice and observe that cell- and tissue-autonomous oscillations are dampened and that animals are l...

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Autores principales:	Masao Doi, Hiroyuki Shimatani, Yuta Atobe, Iori Murai, Hida Hayashi, Yukari Takahashi, Jean-Michel Fustin, Yoshiaki Yamaguchi, Hiroshi Kiyonari, Nobuya Koike, Kazuhiro Yagita, Choogon Lee, Manabu Abe, Kenji Sakimura, Hitoshi Okamura
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/9f27d452176741a7b1daf82753a71800
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spelling	oai:doaj.org-article:9f27d452176741a7b1daf82753a718002021-12-02T14:38:46ZNon-coding cis-element of Period2 is essential for maintaining organismal circadian behaviour and body temperature rhythmicity10.1038/s41467-019-10532-22041-1723https://doaj.org/article/9f27d452176741a7b1daf82753a718002019-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10532-2https://doaj.org/toc/2041-1723The circadian transcription factors BMAL1:CLOCK bind to E/E′-boxes in gene regulatory elements of their targets and facilitate rhythmic expression. Here, the authors mutate the Per2 promoter E’′-box in mice and observe that cell- and tissue-autonomous oscillations are dampened and that animals are less susceptible to jet lag.Masao DoiHiroyuki ShimataniYuta AtobeIori MuraiHida HayashiYukari TakahashiJean-Michel FustinYoshiaki YamaguchiHiroshi KiyonariNobuya KoikeKazuhiro YagitaChoogon LeeManabu AbeKenji SakimuraHitoshi OkamuraNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-9 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Masao Doi Hiroyuki Shimatani Yuta Atobe Iori Murai Hida Hayashi Yukari Takahashi Jean-Michel Fustin Yoshiaki Yamaguchi Hiroshi Kiyonari Nobuya Koike Kazuhiro Yagita Choogon Lee Manabu Abe Kenji Sakimura Hitoshi Okamura Non-coding cis-element of Period2 is essential for maintaining organismal circadian behaviour and body temperature rhythmicity
description	The circadian transcription factors BMAL1:CLOCK bind to E/E′-boxes in gene regulatory elements of their targets and facilitate rhythmic expression. Here, the authors mutate the Per2 promoter E’′-box in mice and observe that cell- and tissue-autonomous oscillations are dampened and that animals are less susceptible to jet lag.
format	article
author	Masao Doi Hiroyuki Shimatani Yuta Atobe Iori Murai Hida Hayashi Yukari Takahashi Jean-Michel Fustin Yoshiaki Yamaguchi Hiroshi Kiyonari Nobuya Koike Kazuhiro Yagita Choogon Lee Manabu Abe Kenji Sakimura Hitoshi Okamura
author_facet	Masao Doi Hiroyuki Shimatani Yuta Atobe Iori Murai Hida Hayashi Yukari Takahashi Jean-Michel Fustin Yoshiaki Yamaguchi Hiroshi Kiyonari Nobuya Koike Kazuhiro Yagita Choogon Lee Manabu Abe Kenji Sakimura Hitoshi Okamura
author_sort	Masao Doi
title	Non-coding cis-element of Period2 is essential for maintaining organismal circadian behaviour and body temperature rhythmicity
title_short	Non-coding cis-element of Period2 is essential for maintaining organismal circadian behaviour and body temperature rhythmicity
title_full	Non-coding cis-element of Period2 is essential for maintaining organismal circadian behaviour and body temperature rhythmicity
title_fullStr	Non-coding cis-element of Period2 is essential for maintaining organismal circadian behaviour and body temperature rhythmicity
title_full_unstemmed	Non-coding cis-element of Period2 is essential for maintaining organismal circadian behaviour and body temperature rhythmicity
title_sort	non-coding cis-element of period2 is essential for maintaining organismal circadian behaviour and body temperature rhythmicity
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/9f27d452176741a7b1daf82753a71800
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Non-coding cis-element of Period2 is essential for maintaining organismal circadian behaviour and body temperature rhythmicity

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