Engrafted parenchymal brain macrophages differ from microglia in transcriptome, chromatin landscape and response to challenge

Irradiation depletes brain microglia cells and induces replenishment of the pool by bone marrow (BM)-derived macrophage. Here the authors show, using mouse BM chimera, that BM-derived macrophages establish long-term residency in the brain, but remain distinct from resident microglia in their transcr...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Anat Shemer, Jonathan Grozovski, Tuan Leng Tay, Jenhan Tao, Alon Volaski, Patrick Süß, Alberto Ardura-Fabregat, Mor Gross-Vered, Jung-Seok Kim, Eyal David, Louise Chappell-Maor, Lars Thielecke, Christopher K. Glass, Kerstin Cornils, Marco Prinz, Steffen Jung
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/9f28b09877e64569b86de53bc8767168
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:9f28b09877e64569b86de53bc8767168
record_format	dspace
spelling	oai:doaj.org-article:9f28b09877e64569b86de53bc87671682021-12-02T13:24:24ZEngrafted parenchymal brain macrophages differ from microglia in transcriptome, chromatin landscape and response to challenge10.1038/s41467-018-07548-52041-1723https://doaj.org/article/9f28b09877e64569b86de53bc87671682018-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07548-5https://doaj.org/toc/2041-1723Irradiation depletes brain microglia cells and induces replenishment of the pool by bone marrow (BM)-derived macrophage. Here the authors show, using mouse BM chimera, that BM-derived macrophages establish long-term residency in the brain, but remain distinct from resident microglia in their transcriptome and gene accessibility landscape.Anat ShemerJonathan GrozovskiTuan Leng TayJenhan TaoAlon VolaskiPatrick SüßAlberto Ardura-FabregatMor Gross-VeredJung-Seok KimEyal DavidLouise Chappell-MaorLars ThieleckeChristopher K. GlassKerstin CornilsMarco PrinzSteffen JungNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Anat Shemer Jonathan Grozovski Tuan Leng Tay Jenhan Tao Alon Volaski Patrick Süß Alberto Ardura-Fabregat Mor Gross-Vered Jung-Seok Kim Eyal David Louise Chappell-Maor Lars Thielecke Christopher K. Glass Kerstin Cornils Marco Prinz Steffen Jung Engrafted parenchymal brain macrophages differ from microglia in transcriptome, chromatin landscape and response to challenge
description	Irradiation depletes brain microglia cells and induces replenishment of the pool by bone marrow (BM)-derived macrophage. Here the authors show, using mouse BM chimera, that BM-derived macrophages establish long-term residency in the brain, but remain distinct from resident microglia in their transcriptome and gene accessibility landscape.
format	article
author	Anat Shemer Jonathan Grozovski Tuan Leng Tay Jenhan Tao Alon Volaski Patrick Süß Alberto Ardura-Fabregat Mor Gross-Vered Jung-Seok Kim Eyal David Louise Chappell-Maor Lars Thielecke Christopher K. Glass Kerstin Cornils Marco Prinz Steffen Jung
author_facet	Anat Shemer Jonathan Grozovski Tuan Leng Tay Jenhan Tao Alon Volaski Patrick Süß Alberto Ardura-Fabregat Mor Gross-Vered Jung-Seok Kim Eyal David Louise Chappell-Maor Lars Thielecke Christopher K. Glass Kerstin Cornils Marco Prinz Steffen Jung
author_sort	Anat Shemer
title	Engrafted parenchymal brain macrophages differ from microglia in transcriptome, chromatin landscape and response to challenge
title_short	Engrafted parenchymal brain macrophages differ from microglia in transcriptome, chromatin landscape and response to challenge
title_full	Engrafted parenchymal brain macrophages differ from microglia in transcriptome, chromatin landscape and response to challenge
title_fullStr	Engrafted parenchymal brain macrophages differ from microglia in transcriptome, chromatin landscape and response to challenge
title_full_unstemmed	Engrafted parenchymal brain macrophages differ from microglia in transcriptome, chromatin landscape and response to challenge
title_sort	engrafted parenchymal brain macrophages differ from microglia in transcriptome, chromatin landscape and response to challenge
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/9f28b09877e64569b86de53bc8767168
work_keys_str_mv	AT anatshemer engraftedparenchymalbrainmacrophagesdifferfrommicrogliaintranscriptomechromatinlandscapeandresponsetochallenge AT jonathangrozovski engraftedparenchymalbrainmacrophagesdifferfrommicrogliaintranscriptomechromatinlandscapeandresponsetochallenge AT tuanlengtay engraftedparenchymalbrainmacrophagesdifferfrommicrogliaintranscriptomechromatinlandscapeandresponsetochallenge AT jenhantao engraftedparenchymalbrainmacrophagesdifferfrommicrogliaintranscriptomechromatinlandscapeandresponsetochallenge AT alonvolaski engraftedparenchymalbrainmacrophagesdifferfrommicrogliaintranscriptomechromatinlandscapeandresponsetochallenge AT patricksuß engraftedparenchymalbrainmacrophagesdifferfrommicrogliaintranscriptomechromatinlandscapeandresponsetochallenge AT albertoardurafabregat engraftedparenchymalbrainmacrophagesdifferfrommicrogliaintranscriptomechromatinlandscapeandresponsetochallenge AT morgrossvered engraftedparenchymalbrainmacrophagesdifferfrommicrogliaintranscriptomechromatinlandscapeandresponsetochallenge AT jungseokkim engraftedparenchymalbrainmacrophagesdifferfrommicrogliaintranscriptomechromatinlandscapeandresponsetochallenge AT eyaldavid engraftedparenchymalbrainmacrophagesdifferfrommicrogliaintranscriptomechromatinlandscapeandresponsetochallenge AT louisechappellmaor engraftedparenchymalbrainmacrophagesdifferfrommicrogliaintranscriptomechromatinlandscapeandresponsetochallenge AT larsthielecke engraftedparenchymalbrainmacrophagesdifferfrommicrogliaintranscriptomechromatinlandscapeandresponsetochallenge AT christopherkglass engraftedparenchymalbrainmacrophagesdifferfrommicrogliaintranscriptomechromatinlandscapeandresponsetochallenge AT kerstincornils engraftedparenchymalbrainmacrophagesdifferfrommicrogliaintranscriptomechromatinlandscapeandresponsetochallenge AT marcoprinz engraftedparenchymalbrainmacrophagesdifferfrommicrogliaintranscriptomechromatinlandscapeandresponsetochallenge AT steffenjung engraftedparenchymalbrainmacrophagesdifferfrommicrogliaintranscriptomechromatinlandscapeandresponsetochallenge
_version_	1718393111113105408

Engrafted parenchymal brain macrophages differ from microglia in transcriptome, chromatin landscape and response to challenge

Ejemplares similares