Current perspectives on the role of IL-17 in autoimmune disease

Hisakata YamadaDivision of Host Defense, Medical Institute of Bioregulation, Kyushu University, Fukuoka, JapanAbstract: Until recently, autoimmune diseases had been categorized as either Th1- or Th2-mediated diseases. However, the discovery of a novel subset of helper T cells producing interleukin (...

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Autor principal:	Hisakata Yamada
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2010
Materias:	Pathology RB1-214 Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/9f2ac3dbf9a744499524a784ba40c565
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spelling	oai:doaj.org-article:9f2ac3dbf9a744499524a784ba40c5652021-12-02T03:08:08ZCurrent perspectives on the role of IL-17 in autoimmune disease1178-7031https://doaj.org/article/9f2ac3dbf9a744499524a784ba40c5652010-06-01T00:00:00Zhttp://www.dovepress.com/current-perspectives-on-the-role-of-il-17-in-autoimmune-disease-a4623https://doaj.org/toc/1178-7031Hisakata YamadaDivision of Host Defense, Medical Institute of Bioregulation, Kyushu University, Fukuoka, JapanAbstract: Until recently, autoimmune diseases had been categorized as either Th1- or Th2-mediated diseases. However, the discovery of a novel subset of helper T cells producing interleukin (IL)-17, ie, Th17 cells, changed this paradigm. Currently, IL-17 and Th17 cells are implicated in many autoimmune diseases, such as rheumatoid arthritis, psoriasis, multiple sclerosis, and inflammatory bowel diseases. Such conclusions were initially drawn from observations in animal models of autoimmune diseases, and accumulating data from clinical research also support the involvement of IL-17 in human diseases as well. Reagents targeting Th17-related molecules have been under clinical investigation for some diseases but have not always been effective in controlling disease activity. Consistent with this, it has become evident that there are substantial differences in the development of Th17 cells and in the way they function in autoimmune diseases between humans and experimental animals. Thus, further investigation is needed before we can draw any conclusions about the importance of IL-17 and Th17 cells in human autoimmune diseases.Keywords: IL-17, Th17, rheumatoid arthritis, multiple sclerosis, Crohn&rsquo;s disease, psoriasis Hisakata YamadaDove Medical PressarticlePathologyRB1-214Therapeutics. PharmacologyRM1-950ENJournal of Inflammation Research, Vol 2010, Iss default, Pp 33-44 (2010)
institution	DOAJ
collection	DOAJ
language	EN
topic	Pathology RB1-214 Therapeutics. Pharmacology RM1-950
spellingShingle	Pathology RB1-214 Therapeutics. Pharmacology RM1-950 Hisakata Yamada Current perspectives on the role of IL-17 in autoimmune disease
description	Hisakata YamadaDivision of Host Defense, Medical Institute of Bioregulation, Kyushu University, Fukuoka, JapanAbstract: Until recently, autoimmune diseases had been categorized as either Th1- or Th2-mediated diseases. However, the discovery of a novel subset of helper T cells producing interleukin (IL)-17, ie, Th17 cells, changed this paradigm. Currently, IL-17 and Th17 cells are implicated in many autoimmune diseases, such as rheumatoid arthritis, psoriasis, multiple sclerosis, and inflammatory bowel diseases. Such conclusions were initially drawn from observations in animal models of autoimmune diseases, and accumulating data from clinical research also support the involvement of IL-17 in human diseases as well. Reagents targeting Th17-related molecules have been under clinical investigation for some diseases but have not always been effective in controlling disease activity. Consistent with this, it has become evident that there are substantial differences in the development of Th17 cells and in the way they function in autoimmune diseases between humans and experimental animals. Thus, further investigation is needed before we can draw any conclusions about the importance of IL-17 and Th17 cells in human autoimmune diseases.Keywords: IL-17, Th17, rheumatoid arthritis, multiple sclerosis, Crohn&rsquo;s disease, psoriasis
format	article
author	Hisakata Yamada
author_facet	Hisakata Yamada
author_sort	Hisakata Yamada
title	Current perspectives on the role of IL-17 in autoimmune disease
title_short	Current perspectives on the role of IL-17 in autoimmune disease
title_full	Current perspectives on the role of IL-17 in autoimmune disease
title_fullStr	Current perspectives on the role of IL-17 in autoimmune disease
title_full_unstemmed	Current perspectives on the role of IL-17 in autoimmune disease
title_sort	current perspectives on the role of il-17 in autoimmune disease
publisher	Dove Medical Press
publishDate	2010
url	https://doaj.org/article/9f2ac3dbf9a744499524a784ba40c565
work_keys_str_mv	AT hisakatayamada currentperspectivesontheroleofil17inautoimmunedisease
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Current perspectives on the role of IL-17 in autoimmune disease

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