A single-channel mechanism for pharmacological potentiation of GluN1/GluN2A NMDA receptors

Abstract NMDA receptors (NMDARs) contribute to several neuropathological processes. Novel positive allosteric modulators (PAMs) of NMDARs have recently been identified but their effects on NMDAR gating remain largely unknown. To this end, we tested the effect of a newly developed molecule UBP684 on...

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Bibliographic Details
Main Authors: Divyan A. Chopra, Kiran Sapkota, Mark W. Irvine, Guangyu Fang, David E. Jane, Daniel T. Monaghan, Shashank M. Dravid
Format: article
Language:EN
Published: Nature Portfolio 2017
Subjects:
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Online Access:https://doaj.org/article/9f33dc1aa5444fdbaec987412ab161fc
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