Toll-like Receptors as a Potential Drug Target for Diabetes Mellitus and Diabetes-associated Complications

Awgichew Shewasinad Yehualashet Pharmacology and Toxicology Unit, Department of Pharmacy, College of Health Sciences, Debre Berhan University, Debre Berhan, EthiopiaCorrespondence: Awgichew Shewasinad YehualashetPharmacology and Toxicology Unit, Department of Pharmacy, College of Health Sciences, De...

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Autor principal:	Yehualashet AS
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	diabetes mellitus tlr immunity inflammation complication Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/9f3839308f7d4602a01fe8691e2cf57b
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spelling	oai:doaj.org-article:9f3839308f7d4602a01fe8691e2cf57b2021-12-02T11:42:27ZToll-like Receptors as a Potential Drug Target for Diabetes Mellitus and Diabetes-associated Complications1178-7007https://doaj.org/article/9f3839308f7d4602a01fe8691e2cf57b2020-12-01T00:00:00Zhttps://www.dovepress.com/toll-like-receptors-as-a-potential-drug-target-for-diabetes-mellitus-a-peer-reviewed-article-DMSOhttps://doaj.org/toc/1178-7007Awgichew Shewasinad Yehualashet Pharmacology and Toxicology Unit, Department of Pharmacy, College of Health Sciences, Debre Berhan University, Debre Berhan, EthiopiaCorrespondence: Awgichew Shewasinad YehualashetPharmacology and Toxicology Unit, Department of Pharmacy, College of Health Sciences, Debre Berhan University, Debre Berhan, EthiopiaTel +251935450290Email awgshewa@gmail.comAbstract: Diabetes mellitus (DM) is a chronic endocrine disease distinguished by hyperglycemia due to disturbance in carbohydrate or lipid metabolism or insulin function. To date, diabetes, and its complications, is established as a global cause of morbidity and mortality. The intended aim during the management of diabetes is to maintain blood glucose close to normal because the majority of patients have poor control of their elevated blood glucose and are highly prone to severe macrovascular and microvascular complications. To decrease the burden of the disease and its complications, scientists from various disciplines are working intensively to identify novel and promising drug targets for diabetes and its complications. Increased and ongoing investigations on mechanisms relating to diabetes and associated complications could potentially consider inflammatory cascades as a promising component of the strategy in the prevention and control of diabetes and its complications. The potential of targeting mediators of inflammation like toll-like receptors (TLRs) are part of current investigation by the scientific community. Hence, the aim of the present review is to discuss the role of TLRs as a potential drug target for diabetes and diabetes associated complications.Keywords: diabetes mellitus, TLR, immunity, inflammation, complicationYehualashet ASDove Medical Pressarticlediabetes mellitustlrimmunityinflammationcomplicationSpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 13, Pp 4763-4777 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	diabetes mellitus tlr immunity inflammation complication Specialties of internal medicine RC581-951
spellingShingle	diabetes mellitus tlr immunity inflammation complication Specialties of internal medicine RC581-951 Yehualashet AS Toll-like Receptors as a Potential Drug Target for Diabetes Mellitus and Diabetes-associated Complications
description	Awgichew Shewasinad Yehualashet Pharmacology and Toxicology Unit, Department of Pharmacy, College of Health Sciences, Debre Berhan University, Debre Berhan, EthiopiaCorrespondence: Awgichew Shewasinad YehualashetPharmacology and Toxicology Unit, Department of Pharmacy, College of Health Sciences, Debre Berhan University, Debre Berhan, EthiopiaTel +251935450290Email awgshewa@gmail.comAbstract: Diabetes mellitus (DM) is a chronic endocrine disease distinguished by hyperglycemia due to disturbance in carbohydrate or lipid metabolism or insulin function. To date, diabetes, and its complications, is established as a global cause of morbidity and mortality. The intended aim during the management of diabetes is to maintain blood glucose close to normal because the majority of patients have poor control of their elevated blood glucose and are highly prone to severe macrovascular and microvascular complications. To decrease the burden of the disease and its complications, scientists from various disciplines are working intensively to identify novel and promising drug targets for diabetes and its complications. Increased and ongoing investigations on mechanisms relating to diabetes and associated complications could potentially consider inflammatory cascades as a promising component of the strategy in the prevention and control of diabetes and its complications. The potential of targeting mediators of inflammation like toll-like receptors (TLRs) are part of current investigation by the scientific community. Hence, the aim of the present review is to discuss the role of TLRs as a potential drug target for diabetes and diabetes associated complications.Keywords: diabetes mellitus, TLR, immunity, inflammation, complication
format	article
author	Yehualashet AS
author_facet	Yehualashet AS
author_sort	Yehualashet AS
title	Toll-like Receptors as a Potential Drug Target for Diabetes Mellitus and Diabetes-associated Complications
title_short	Toll-like Receptors as a Potential Drug Target for Diabetes Mellitus and Diabetes-associated Complications
title_full	Toll-like Receptors as a Potential Drug Target for Diabetes Mellitus and Diabetes-associated Complications
title_fullStr	Toll-like Receptors as a Potential Drug Target for Diabetes Mellitus and Diabetes-associated Complications
title_full_unstemmed	Toll-like Receptors as a Potential Drug Target for Diabetes Mellitus and Diabetes-associated Complications
title_sort	toll-like receptors as a potential drug target for diabetes mellitus and diabetes-associated complications
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/9f3839308f7d4602a01fe8691e2cf57b
work_keys_str_mv	AT yehualashetas tolllikereceptorsasapotentialdrugtargetfordiabetesmellitusanddiabetesassociatedcomplications
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Toll-like Receptors as a Potential Drug Target for Diabetes Mellitus and Diabetes-associated Complications

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