IMMUNE INDEXES IN PATIENTS WITH PROGRESSIVE FIBROUS-CAVERNOUS TUBERCULOSIS DEPENDENT ON SEVERITY OF DESTRUCTIVE CHANGES IN THE LUNGS

Abstract. We have studied cellular immune state in patients with progressive fibrous cavernous tuberculosis (FCT) with varying severity of lung destructive changes. It was found that increasing number of specific cytotoxic lymphocytes, NK-, NKT-, CD95-cells and activated T-lymphocytes, accompanied b...

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Autores principales:	B. E. Knoring, N. A. Davydova, T. S. Basek, N. A. Nica, A. V. Elkin
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	tuberculosis destruction lymphocytes cytokines Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/9f3a8c1568a147689e75afbd34ba1370
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spelling	oai:doaj.org-article:9f3a8c1568a147689e75afbd34ba13702021-11-18T08:03:41ZIMMUNE INDEXES IN PATIENTS WITH PROGRESSIVE FIBROUS-CAVERNOUS TUBERCULOSIS DEPENDENT ON SEVERITY OF DESTRUCTIVE CHANGES IN THE LUNGS1563-06252313-741X10.15789/1563-0625-2012-4-5-329-336https://doaj.org/article/9f3a8c1568a147689e75afbd34ba13702014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/457https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XAbstract. We have studied cellular immune state in patients with progressive fibrous cavernous tuberculosis (FCT) with varying severity of lung destructive changes. It was found that increasing number of specific cytotoxic lymphocytes, NK-, NKT-, CD95-cells and activated T-lymphocytes, accompanied by a significant decrease of T-helper cells, B cells, CD25-cells, is a sign of destruction, along with inhibition of antigen-specific cellular response and functional insufficiency of T-helper and cytotoxic lymphocytes. Increased severity of the disease is consistent with activation of B cell compartment and weaker phagocytic function of neutrophils.Significant differences were revealed in spontaneous and induced production of IFNγ, IL-2 and IL-8 between various groups of patients with FCT. The alterations of immune and cytokine status in a certain clinical subgroup with progressing FCT were indicative for depletion of immune system potential. As based on these data, we have established some criteria in order to assess severity of immune pathology in the patients with progressing FCT which may be of predictive value for evaluating trends in development of the specific process and feasibility of immune correction therapy.B. E. KnoringN. A. DavydovaT. S. BasekN. A. NicaA. V. ElkinSPb RAACIarticletuberculosisdestructionlymphocytescytokinesImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 14, Iss 4-5, Pp 329-336 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	tuberculosis destruction lymphocytes cytokines Immunologic diseases. Allergy RC581-607
spellingShingle	tuberculosis destruction lymphocytes cytokines Immunologic diseases. Allergy RC581-607 B. E. Knoring N. A. Davydova T. S. Basek N. A. Nica A. V. Elkin IMMUNE INDEXES IN PATIENTS WITH PROGRESSIVE FIBROUS-CAVERNOUS TUBERCULOSIS DEPENDENT ON SEVERITY OF DESTRUCTIVE CHANGES IN THE LUNGS
description	Abstract. We have studied cellular immune state in patients with progressive fibrous cavernous tuberculosis (FCT) with varying severity of lung destructive changes. It was found that increasing number of specific cytotoxic lymphocytes, NK-, NKT-, CD95-cells and activated T-lymphocytes, accompanied by a significant decrease of T-helper cells, B cells, CD25-cells, is a sign of destruction, along with inhibition of antigen-specific cellular response and functional insufficiency of T-helper and cytotoxic lymphocytes. Increased severity of the disease is consistent with activation of B cell compartment and weaker phagocytic function of neutrophils.Significant differences were revealed in spontaneous and induced production of IFNγ, IL-2 and IL-8 between various groups of patients with FCT. The alterations of immune and cytokine status in a certain clinical subgroup with progressing FCT were indicative for depletion of immune system potential. As based on these data, we have established some criteria in order to assess severity of immune pathology in the patients with progressing FCT which may be of predictive value for evaluating trends in development of the specific process and feasibility of immune correction therapy.
format	article
author	B. E. Knoring N. A. Davydova T. S. Basek N. A. Nica A. V. Elkin
author_facet	B. E. Knoring N. A. Davydova T. S. Basek N. A. Nica A. V. Elkin
author_sort	B. E. Knoring
title	IMMUNE INDEXES IN PATIENTS WITH PROGRESSIVE FIBROUS-CAVERNOUS TUBERCULOSIS DEPENDENT ON SEVERITY OF DESTRUCTIVE CHANGES IN THE LUNGS
title_short	IMMUNE INDEXES IN PATIENTS WITH PROGRESSIVE FIBROUS-CAVERNOUS TUBERCULOSIS DEPENDENT ON SEVERITY OF DESTRUCTIVE CHANGES IN THE LUNGS
title_full	IMMUNE INDEXES IN PATIENTS WITH PROGRESSIVE FIBROUS-CAVERNOUS TUBERCULOSIS DEPENDENT ON SEVERITY OF DESTRUCTIVE CHANGES IN THE LUNGS
title_fullStr	IMMUNE INDEXES IN PATIENTS WITH PROGRESSIVE FIBROUS-CAVERNOUS TUBERCULOSIS DEPENDENT ON SEVERITY OF DESTRUCTIVE CHANGES IN THE LUNGS
title_full_unstemmed	IMMUNE INDEXES IN PATIENTS WITH PROGRESSIVE FIBROUS-CAVERNOUS TUBERCULOSIS DEPENDENT ON SEVERITY OF DESTRUCTIVE CHANGES IN THE LUNGS
title_sort	immune indexes in patients with progressive fibrous-cavernous tuberculosis dependent on severity of destructive changes in the lungs
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/9f3a8c1568a147689e75afbd34ba1370
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IMMUNE INDEXES IN PATIENTS WITH PROGRESSIVE FIBROUS-CAVERNOUS TUBERCULOSIS DEPENDENT ON SEVERITY OF DESTRUCTIVE CHANGES IN THE LUNGS

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