Human FOXN1-deficiency is associated with αβ double-negative and FoxP3+ T-cell expansions that are distinctly modulated upon thymic transplantation.

Human FOXN1-deficiency is associated with αβ double-negative and FoxP3+ T-cell expansions that are distinctly modulated upon thymic transplantation.

Forkhead box N1 (FOXN1) is a transcription factor crucial for thymic epithelium development and prevention of its involution. Investigation of a patient with a rare homozygous FOXN1 mutation (R255X), leading to alopecia universalis and thymus aplasia, unexpectedly revealed non-maternal circulating T...

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Autores principales: Adriana S Albuquerque, José G Marques, Susana L Silva, Dario Ligeiro, Blythe H Devlin, Jacques Dutrieux, Rémi Cheynier, Claudio Pignata, Rui M M Victorino, M Louise Markert, Ana E Sousa
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2012
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/9f3b322d36ec49c49ade3fd6d5172c7d
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