Human FOXN1-deficiency is associated with αβ double-negative and FoxP3+ T-cell expansions that are distinctly modulated upon thymic transplantation.
Forkhead box N1 (FOXN1) is a transcription factor crucial for thymic epithelium development and prevention of its involution. Investigation of a patient with a rare homozygous FOXN1 mutation (R255X), leading to alopecia universalis and thymus aplasia, unexpectedly revealed non-maternal circulating T...
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Main Authors: | Adriana S Albuquerque, José G Marques, Susana L Silva, Dario Ligeiro, Blythe H Devlin, Jacques Dutrieux, Rémi Cheynier, Claudio Pignata, Rui M M Victorino, M Louise Markert, Ana E Sousa |
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Format: | article |
Language: | EN |
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Public Library of Science (PLoS)
2012
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Online Access: | https://doaj.org/article/9f3b322d36ec49c49ade3fd6d5172c7d |
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