Disrupted topological organization of human brain connectome in diabetic retinopathy patients

Xin Huang, Yan Tong, Chen-Xing Qi, Yang-Tao Xu, Han-Dong Dan, Yin ShenEye Center, Renmin Hospital of Wuhan University, Wuhan 430060, Hubei, People’s Republic of ChinaCorrespondence: Yin ShenEye Center, Renmin Hospital of Wuhan University, No 238, Jie Fang Road, Wu Chang District, Wuhan 430...

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Autores principales:	Huang X, Tong Y, Qi CX, Xu YT, Dan HD, Shen Y
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	diabetic retinopathy graph theory functional connectome resting-state functional magnetic resonance imaging Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/9f3b4280757840b6a2b1f46e85d9bee9
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spelling	oai:doaj.org-article:9f3b4280757840b6a2b1f46e85d9bee92021-12-02T08:38:18ZDisrupted topological organization of human brain connectome in diabetic retinopathy patients1178-2021https://doaj.org/article/9f3b4280757840b6a2b1f46e85d9bee92019-08-01T00:00:00Zhttps://www.dovepress.com/disrupted-topological-organization-of-human-brain-connectome-in-diabet-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Xin Huang, Yan Tong, Chen-Xing Qi, Yang-Tao Xu, Han-Dong Dan, Yin ShenEye Center, Renmin Hospital of Wuhan University, Wuhan 430060, Hubei, People’s Republic of ChinaCorrespondence: Yin ShenEye Center, Renmin Hospital of Wuhan University, No 238, Jie Fang Road, Wu Chang District, Wuhan 430060, Hubei, People’s Republic of ChinaTel +86 1 387 155 0513Email yinshen@whu.edu.cnObjective: There is increasing neuroimaging evidence that type 2 diabetes patients with retinal microvascular complications show abnormal brain functional and structural architecture and are at an increased risk of cognitive decline and dementia. However, changes in the topological properties of the functional brain connectome in diabetic retinopathy (DR) patients remain unknown. The aim of this study was to explore the topological organization of the brain connectome in DR patients using graph theory approaches.Methods: Thirty-five DR patients (18 males and 17 females) and 38 healthy controls (HCs) (18 males and 20 females), matched for age, sex, and education, underwent resting-state magnetic resonance imaging scans. Graph theory analysis was performed to investigate the topological properties of brain functional connectome at both global and nodal levels.Results: Both DR and HC groups showed high-efficiency small-world network in their brain functional networks. Notably, the DR group showed reduction in the clustering coefficient (P=0.0572) and local efficiency (P=0.0151). Furthermore, the DR group showed reduced nodal centralities in the default-mode network (DMN) and increased nodal centralities in the visual network (VN) (P<0.01, Bonferroni-corrected). The DR group also showed abnormal functional connections among the VN, DMN, salience network (SN), and sensorimotor network (SMN). Altered network metrics and nodal centralities were significantly correlated with visual acuity and fasting blood glucose level in DR patients.Conclusion: DR patients showed abnormal topological organization of the human brain connectome. Specifically, the DR group showed reduction in the clustering coefficient and local efficiency, relative to HC group. Abnormal nodal centralities and functional disconnections were mainly located in the DMN, VN, SN, and SMN in DR patients. Furthermore, the disrupted topological attributes showed correlations with clinical variables. These findings offer important insight into the neural mechanism of visual loss and cognitive deficits in DR patients.Keywords: diabetic retinopathy, graph theory, functional connectome, resting-state functional magnetic resonance imagingHuang XTong YQi CXXu YTDan HDShen YDove Medical Pressarticlediabetic retinopathygraph theoryfunctional connectomeresting-state functional magnetic resonance imagingNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 15, Pp 2487-2502 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	diabetic retinopathy graph theory functional connectome resting-state functional magnetic resonance imaging Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	diabetic retinopathy graph theory functional connectome resting-state functional magnetic resonance imaging Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Huang X Tong Y Qi CX Xu YT Dan HD Shen Y Disrupted topological organization of human brain connectome in diabetic retinopathy patients
description	Xin Huang, Yan Tong, Chen-Xing Qi, Yang-Tao Xu, Han-Dong Dan, Yin ShenEye Center, Renmin Hospital of Wuhan University, Wuhan 430060, Hubei, People’s Republic of ChinaCorrespondence: Yin ShenEye Center, Renmin Hospital of Wuhan University, No 238, Jie Fang Road, Wu Chang District, Wuhan 430060, Hubei, People’s Republic of ChinaTel +86 1 387 155 0513Email yinshen@whu.edu.cnObjective: There is increasing neuroimaging evidence that type 2 diabetes patients with retinal microvascular complications show abnormal brain functional and structural architecture and are at an increased risk of cognitive decline and dementia. However, changes in the topological properties of the functional brain connectome in diabetic retinopathy (DR) patients remain unknown. The aim of this study was to explore the topological organization of the brain connectome in DR patients using graph theory approaches.Methods: Thirty-five DR patients (18 males and 17 females) and 38 healthy controls (HCs) (18 males and 20 females), matched for age, sex, and education, underwent resting-state magnetic resonance imaging scans. Graph theory analysis was performed to investigate the topological properties of brain functional connectome at both global and nodal levels.Results: Both DR and HC groups showed high-efficiency small-world network in their brain functional networks. Notably, the DR group showed reduction in the clustering coefficient (P=0.0572) and local efficiency (P=0.0151). Furthermore, the DR group showed reduced nodal centralities in the default-mode network (DMN) and increased nodal centralities in the visual network (VN) (P<0.01, Bonferroni-corrected). The DR group also showed abnormal functional connections among the VN, DMN, salience network (SN), and sensorimotor network (SMN). Altered network metrics and nodal centralities were significantly correlated with visual acuity and fasting blood glucose level in DR patients.Conclusion: DR patients showed abnormal topological organization of the human brain connectome. Specifically, the DR group showed reduction in the clustering coefficient and local efficiency, relative to HC group. Abnormal nodal centralities and functional disconnections were mainly located in the DMN, VN, SN, and SMN in DR patients. Furthermore, the disrupted topological attributes showed correlations with clinical variables. These findings offer important insight into the neural mechanism of visual loss and cognitive deficits in DR patients.Keywords: diabetic retinopathy, graph theory, functional connectome, resting-state functional magnetic resonance imaging
format	article
author	Huang X Tong Y Qi CX Xu YT Dan HD Shen Y
author_facet	Huang X Tong Y Qi CX Xu YT Dan HD Shen Y
author_sort	Huang X
title	Disrupted topological organization of human brain connectome in diabetic retinopathy patients
title_short	Disrupted topological organization of human brain connectome in diabetic retinopathy patients
title_full	Disrupted topological organization of human brain connectome in diabetic retinopathy patients
title_fullStr	Disrupted topological organization of human brain connectome in diabetic retinopathy patients
title_full_unstemmed	Disrupted topological organization of human brain connectome in diabetic retinopathy patients
title_sort	disrupted topological organization of human brain connectome in diabetic retinopathy patients
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/9f3b4280757840b6a2b1f46e85d9bee9
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_version_	1718398428709388288

Disrupted topological organization of human brain connectome in diabetic retinopathy patients

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