Rod pathway and cone pathway retinal dysfunction in the 5xFAD mouse model of Alzheimer’s disease

Abstract To characterize rod- and cone-pathway function in the 5xFAD mouse model of Alzheimer’s disease (AD) using the full-field electroretinogram (ERG). Dark-adapted (DA; rod-pathway) and light-adapted (LA; cone-pathway) ERGs were recorded from three-month-old 5xFAD and wild type (WT) mice. ERGs w...

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Autores principales:	J. Jason McAnany, Nathanael Matei, Yi-Fan Chen, Karen Liu, Jason C. Park, Mahnaz Shahidi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/9f3da13689e44b65bc357740fe0f6c9a
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spelling	oai:doaj.org-article:9f3da13689e44b65bc357740fe0f6c9a2021-12-02T15:54:06ZRod pathway and cone pathway retinal dysfunction in the 5xFAD mouse model of Alzheimer’s disease10.1038/s41598-021-84318-22045-2322https://doaj.org/article/9f3da13689e44b65bc357740fe0f6c9a2021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-84318-2https://doaj.org/toc/2045-2322Abstract To characterize rod- and cone-pathway function in the 5xFAD mouse model of Alzheimer’s disease (AD) using the full-field electroretinogram (ERG). Dark-adapted (DA; rod-pathway) and light-adapted (LA; cone-pathway) ERGs were recorded from three-month-old 5xFAD and wild type (WT) mice. ERGs were elicited by achromatic flashes (0.01–25 cd-s-m− 2). Amplitude and implicit time (IT) of the a-wave, b-wave, and oscillatory potentials (OPs) were calculated according to convention. In addition, the amplitude and IT of the photopic negative response (PhNR) were measured from the LA recordings. Amplitude and IT differences between the 5xFAD and WT groups were evaluated using quantile regression models. Under DA conditions, there were significant differences between the 5xFAD and WT groups in post-receptor function, whereas photoreceptor function did not differ significantly. Specifically, the DA a-wave amplitude did not differ between groups (p = 0.87), whereas the b-wave amplitude was reduced in the 5xFAD mice (p = 0.003). There were significant OP (p < 0.001) and a-wave (p = 0.04) delays, but the a-wave delay may be attributable to a post-receptor abnormality. Under LA conditions, the only 5xFAD abnormalities were in the PhNR, which was reduced (p = 0.009) and delayed (p = 0.04). The full-field ERG can be abnormal in the 5xFAD model of AD, with the greatest effects on post-receptor rod pathway function. These results indicate that retinal electrophysiology may be a useful tool for evaluating neural dysfunction in AD.J. Jason McAnanyNathanael MateiYi-Fan ChenKaren LiuJason C. ParkMahnaz ShahidiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q J. Jason McAnany Nathanael Matei Yi-Fan Chen Karen Liu Jason C. Park Mahnaz Shahidi Rod pathway and cone pathway retinal dysfunction in the 5xFAD mouse model of Alzheimer’s disease
description	Abstract To characterize rod- and cone-pathway function in the 5xFAD mouse model of Alzheimer’s disease (AD) using the full-field electroretinogram (ERG). Dark-adapted (DA; rod-pathway) and light-adapted (LA; cone-pathway) ERGs were recorded from three-month-old 5xFAD and wild type (WT) mice. ERGs were elicited by achromatic flashes (0.01–25 cd-s-m− 2). Amplitude and implicit time (IT) of the a-wave, b-wave, and oscillatory potentials (OPs) were calculated according to convention. In addition, the amplitude and IT of the photopic negative response (PhNR) were measured from the LA recordings. Amplitude and IT differences between the 5xFAD and WT groups were evaluated using quantile regression models. Under DA conditions, there were significant differences between the 5xFAD and WT groups in post-receptor function, whereas photoreceptor function did not differ significantly. Specifically, the DA a-wave amplitude did not differ between groups (p = 0.87), whereas the b-wave amplitude was reduced in the 5xFAD mice (p = 0.003). There were significant OP (p < 0.001) and a-wave (p = 0.04) delays, but the a-wave delay may be attributable to a post-receptor abnormality. Under LA conditions, the only 5xFAD abnormalities were in the PhNR, which was reduced (p = 0.009) and delayed (p = 0.04). The full-field ERG can be abnormal in the 5xFAD model of AD, with the greatest effects on post-receptor rod pathway function. These results indicate that retinal electrophysiology may be a useful tool for evaluating neural dysfunction in AD.
format	article
author	J. Jason McAnany Nathanael Matei Yi-Fan Chen Karen Liu Jason C. Park Mahnaz Shahidi
author_facet	J. Jason McAnany Nathanael Matei Yi-Fan Chen Karen Liu Jason C. Park Mahnaz Shahidi
author_sort	J. Jason McAnany
title	Rod pathway and cone pathway retinal dysfunction in the 5xFAD mouse model of Alzheimer’s disease
title_short	Rod pathway and cone pathway retinal dysfunction in the 5xFAD mouse model of Alzheimer’s disease
title_full	Rod pathway and cone pathway retinal dysfunction in the 5xFAD mouse model of Alzheimer’s disease
title_fullStr	Rod pathway and cone pathway retinal dysfunction in the 5xFAD mouse model of Alzheimer’s disease
title_full_unstemmed	Rod pathway and cone pathway retinal dysfunction in the 5xFAD mouse model of Alzheimer’s disease
title_sort	rod pathway and cone pathway retinal dysfunction in the 5xfad mouse model of alzheimer’s disease
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/9f3da13689e44b65bc357740fe0f6c9a
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Rod pathway and cone pathway retinal dysfunction in the 5xFAD mouse model of Alzheimer’s disease

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