Recent Advances Toward the Use of Mesoporous Silica Nanoparticles for the Treatment of Bacterial Infections

Rafael R Castillo,1 María Vallet-Regí1– 3 1Dpto. Química en Ciencias Farmacéuticas, Facultad de Farmacia, Universidad Complutense de Madrid, Madrid, 28040, Spain; 2Centro de Investigación Biomédica en Red—CIBER, Madrid, 28029, Spain; 3Instituto de Investigación Sanitaria Hospital 12 de Octubre—imas1...

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Autores principales:	Castillo RR, Vallet-Regí M
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	mesoporous silica bacteria infection combination therapy drug delivery Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/9f4091c570bd43ef8b37a863137c5e64
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spelling	oai:doaj.org-article:9f4091c570bd43ef8b37a863137c5e642021-12-02T18:47:42ZRecent Advances Toward the Use of Mesoporous Silica Nanoparticles for the Treatment of Bacterial Infections1178-2013https://doaj.org/article/9f4091c570bd43ef8b37a863137c5e642021-06-01T00:00:00Zhttps://www.dovepress.com/recent-advances-toward-the-use-of-mesoporous-silica-nanoparticles-for--peer-reviewed-fulltext-article-IJNhttps://doaj.org/toc/1178-2013Rafael R Castillo,1 María Vallet-Regí1– 3 1Dpto. Química en Ciencias Farmacéuticas, Facultad de Farmacia, Universidad Complutense de Madrid, Madrid, 28040, Spain; 2Centro de Investigación Biomédica en Red—CIBER, Madrid, 28029, Spain; 3Instituto de Investigación Sanitaria Hospital 12 de Octubre—imas12, Madrid, 28041, SpainCorrespondence: Rafael R Castillo; María Vallet-Reg&#x00EDDpto. Química en Ciencias Farmacéuticas, Facultad de Farmacia, Universidad Complutense de Madrid, Plaza Ramón y Cajal s/n, Madrid, 28040, SpainTel +34 91 394 1843Email rafcas01@ucm.es; vallet@ucm.esAbstract: It is a fact that the use of antibiotics is inducing a growing resistance on bacteria. This situation is not only the consequence of a drugs’ misuse, but a direct consequence of a widespread and continuous use. Current studies suggest that this effect could be reversed by using abandoned antibiotics to which bacteria have lost their resistance, but this is only a temporary solution that in near future would lead to new resistance problems. Fortunately, current nanotechnology offers a new life for old and new antibiotics, which could have significantly different pharmacokinetics when properly delivered; enabling new routes able to bypass acquired resistances. In this contribution, we will focus on the use of porous silica nanoparticles as functional carriers for the delivery of antibiotics and biocides in combination with additional features like membrane sensitizing and heavy metal-driven metabolic-disrupting therapies as two of the most interesting combination therapies.Keywords: mesoporous silica, bacteria, infection, combination therapy, drug deliveryCastillo RRVallet-Regí MDove Medical Pressarticlemesoporous silicabacteriainfectioncombination therapydrug deliveryMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 16, Pp 4409-4430 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	mesoporous silica bacteria infection combination therapy drug delivery Medicine (General) R5-920
spellingShingle	mesoporous silica bacteria infection combination therapy drug delivery Medicine (General) R5-920 Castillo RR Vallet-Regí M Recent Advances Toward the Use of Mesoporous Silica Nanoparticles for the Treatment of Bacterial Infections
description	Rafael R Castillo,1 María Vallet-Regí1– 3 1Dpto. Química en Ciencias Farmacéuticas, Facultad de Farmacia, Universidad Complutense de Madrid, Madrid, 28040, Spain; 2Centro de Investigación Biomédica en Red—CIBER, Madrid, 28029, Spain; 3Instituto de Investigación Sanitaria Hospital 12 de Octubre—imas12, Madrid, 28041, SpainCorrespondence: Rafael R Castillo; María Vallet-Reg&#x00EDDpto. Química en Ciencias Farmacéuticas, Facultad de Farmacia, Universidad Complutense de Madrid, Plaza Ramón y Cajal s/n, Madrid, 28040, SpainTel +34 91 394 1843Email rafcas01@ucm.es; vallet@ucm.esAbstract: It is a fact that the use of antibiotics is inducing a growing resistance on bacteria. This situation is not only the consequence of a drugs’ misuse, but a direct consequence of a widespread and continuous use. Current studies suggest that this effect could be reversed by using abandoned antibiotics to which bacteria have lost their resistance, but this is only a temporary solution that in near future would lead to new resistance problems. Fortunately, current nanotechnology offers a new life for old and new antibiotics, which could have significantly different pharmacokinetics when properly delivered; enabling new routes able to bypass acquired resistances. In this contribution, we will focus on the use of porous silica nanoparticles as functional carriers for the delivery of antibiotics and biocides in combination with additional features like membrane sensitizing and heavy metal-driven metabolic-disrupting therapies as two of the most interesting combination therapies.Keywords: mesoporous silica, bacteria, infection, combination therapy, drug delivery
format	article
author	Castillo RR Vallet-Regí M
author_facet	Castillo RR Vallet-Regí M
author_sort	Castillo RR
title	Recent Advances Toward the Use of Mesoporous Silica Nanoparticles for the Treatment of Bacterial Infections
title_short	Recent Advances Toward the Use of Mesoporous Silica Nanoparticles for the Treatment of Bacterial Infections
title_full	Recent Advances Toward the Use of Mesoporous Silica Nanoparticles for the Treatment of Bacterial Infections
title_fullStr	Recent Advances Toward the Use of Mesoporous Silica Nanoparticles for the Treatment of Bacterial Infections
title_full_unstemmed	Recent Advances Toward the Use of Mesoporous Silica Nanoparticles for the Treatment of Bacterial Infections
title_sort	recent advances toward the use of mesoporous silica nanoparticles for the treatment of bacterial infections
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/9f4091c570bd43ef8b37a863137c5e64
work_keys_str_mv	AT castillorr recentadvancestowardtheuseofmesoporoussilicananoparticlesforthetreatmentofbacterialinfections AT valletregim recentadvancestowardtheuseofmesoporoussilicananoparticlesforthetreatmentofbacterialinfections
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Recent Advances Toward the Use of Mesoporous Silica Nanoparticles for the Treatment of Bacterial Infections

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