Recent Advances Toward the Use of Mesoporous Silica Nanoparticles for the Treatment of Bacterial Infections

Rafael R Castillo,1 María Vallet-Regí1– 3 1Dpto. Química en Ciencias Farmacéuticas, Facultad de Farmacia, Universidad Complutense de Madrid, Madrid, 28040, Spain; 2Centro de Investigación Biomédica en Red—CIBER, Madrid, 28029, Spain; 3Instituto de Investigación Sanitaria Hospital 12 de Octubre—imas1...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Castillo RR, Vallet-Regí M
Formato: article
Lenguaje:EN
Publicado: Dove Medical Press 2021
Materias:
Acceso en línea:https://doaj.org/article/9f4091c570bd43ef8b37a863137c5e64
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
id oai:doaj.org-article:9f4091c570bd43ef8b37a863137c5e64
record_format dspace
spelling oai:doaj.org-article:9f4091c570bd43ef8b37a863137c5e642021-12-02T18:47:42ZRecent Advances Toward the Use of Mesoporous Silica Nanoparticles for the Treatment of Bacterial Infections1178-2013https://doaj.org/article/9f4091c570bd43ef8b37a863137c5e642021-06-01T00:00:00Zhttps://www.dovepress.com/recent-advances-toward-the-use-of-mesoporous-silica-nanoparticles-for--peer-reviewed-fulltext-article-IJNhttps://doaj.org/toc/1178-2013Rafael R Castillo,1 María Vallet-Regí1– 3 1Dpto. Química en Ciencias Farmacéuticas, Facultad de Farmacia, Universidad Complutense de Madrid, Madrid, 28040, Spain; 2Centro de Investigación Biomédica en Red—CIBER, Madrid, 28029, Spain; 3Instituto de Investigación Sanitaria Hospital 12 de Octubre—imas12, Madrid, 28041, SpainCorrespondence: Rafael R Castillo; María Vallet-Reg&#x00EDDpto. Química en Ciencias Farmacéuticas, Facultad de Farmacia, Universidad Complutense de Madrid, Plaza Ramón y Cajal s/n, Madrid, 28040, SpainTel +34 91 394 1843Email rafcas01@ucm.es; vallet@ucm.esAbstract: It is a fact that the use of antibiotics is inducing a growing resistance on bacteria. This situation is not only the consequence of a drugs’ misuse, but a direct consequence of a widespread and continuous use. Current studies suggest that this effect could be reversed by using abandoned antibiotics to which bacteria have lost their resistance, but this is only a temporary solution that in near future would lead to new resistance problems. Fortunately, current nanotechnology offers a new life for old and new antibiotics, which could have significantly different pharmacokinetics when properly delivered; enabling new routes able to bypass acquired resistances. In this contribution, we will focus on the use of porous silica nanoparticles as functional carriers for the delivery of antibiotics and biocides in combination with additional features like membrane sensitizing and heavy metal-driven metabolic-disrupting therapies as two of the most interesting combination therapies.Keywords: mesoporous silica, bacteria, infection, combination therapy, drug deliveryCastillo RRVallet-Regí MDove Medical Pressarticlemesoporous silicabacteriainfectioncombination therapydrug deliveryMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 16, Pp 4409-4430 (2021)
institution DOAJ
collection DOAJ
language EN
topic mesoporous silica
bacteria
infection
combination therapy
drug delivery
Medicine (General)
R5-920
spellingShingle mesoporous silica
bacteria
infection
combination therapy
drug delivery
Medicine (General)
R5-920
Castillo RR
Vallet-Regí M
Recent Advances Toward the Use of Mesoporous Silica Nanoparticles for the Treatment of Bacterial Infections
description Rafael R Castillo,1 María Vallet-Regí1– 3 1Dpto. Química en Ciencias Farmacéuticas, Facultad de Farmacia, Universidad Complutense de Madrid, Madrid, 28040, Spain; 2Centro de Investigación Biomédica en Red—CIBER, Madrid, 28029, Spain; 3Instituto de Investigación Sanitaria Hospital 12 de Octubre—imas12, Madrid, 28041, SpainCorrespondence: Rafael R Castillo; María Vallet-Reg&#x00EDDpto. Química en Ciencias Farmacéuticas, Facultad de Farmacia, Universidad Complutense de Madrid, Plaza Ramón y Cajal s/n, Madrid, 28040, SpainTel +34 91 394 1843Email rafcas01@ucm.es; vallet@ucm.esAbstract: It is a fact that the use of antibiotics is inducing a growing resistance on bacteria. This situation is not only the consequence of a drugs’ misuse, but a direct consequence of a widespread and continuous use. Current studies suggest that this effect could be reversed by using abandoned antibiotics to which bacteria have lost their resistance, but this is only a temporary solution that in near future would lead to new resistance problems. Fortunately, current nanotechnology offers a new life for old and new antibiotics, which could have significantly different pharmacokinetics when properly delivered; enabling new routes able to bypass acquired resistances. In this contribution, we will focus on the use of porous silica nanoparticles as functional carriers for the delivery of antibiotics and biocides in combination with additional features like membrane sensitizing and heavy metal-driven metabolic-disrupting therapies as two of the most interesting combination therapies.Keywords: mesoporous silica, bacteria, infection, combination therapy, drug delivery
format article
author Castillo RR
Vallet-Regí M
author_facet Castillo RR
Vallet-Regí M
author_sort Castillo RR
title Recent Advances Toward the Use of Mesoporous Silica Nanoparticles for the Treatment of Bacterial Infections
title_short Recent Advances Toward the Use of Mesoporous Silica Nanoparticles for the Treatment of Bacterial Infections
title_full Recent Advances Toward the Use of Mesoporous Silica Nanoparticles for the Treatment of Bacterial Infections
title_fullStr Recent Advances Toward the Use of Mesoporous Silica Nanoparticles for the Treatment of Bacterial Infections
title_full_unstemmed Recent Advances Toward the Use of Mesoporous Silica Nanoparticles for the Treatment of Bacterial Infections
title_sort recent advances toward the use of mesoporous silica nanoparticles for the treatment of bacterial infections
publisher Dove Medical Press
publishDate 2021
url https://doaj.org/article/9f4091c570bd43ef8b37a863137c5e64
work_keys_str_mv AT castillorr recentadvancestowardtheuseofmesoporoussilicananoparticlesforthetreatmentofbacterialinfections
AT valletregim recentadvancestowardtheuseofmesoporoussilicananoparticlesforthetreatmentofbacterialinfections
_version_ 1718377640577990656