The Host Cell Metabolite Inositol Hexakisphosphate Promotes Efficient Endogenous HIV-1 Reverse Transcription by Stabilizing the Viral Capsid

ABSTRACT A defining activity of retroviruses is reverse transcription, the process by which the viral genomic RNA is converted into the double-stranded DNA required for virus replication. Reverse transcriptase (RT), the viral enzyme responsible for this process, was identified in 1970 by assaying pe...

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Autores principales: Jordan Jennings, Jiong Shi, Janani Varadarajan, Parker J. Jamieson, Christopher Aiken
Formato: article
Lenguaje:EN
Publicado: American Society for Microbiology 2020
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IP6
Acceso en línea:https://doaj.org/article/9f4588bdb95c474798f388647168f867
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