Cleavage of DNA and RNA by PLD3 and PLD4 limits autoinflammatory triggering by multiple sensors

Loss of function polymorphisms of phospholipase D3 and D4 are associated with inflammatory diseases and their function is unclear. Here the authors show that PLD3/4 function as RNAses and deletion of these proteins in mice leads to accumulation of ssRNA which exacerbates inflammation through TLR sig...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Amanda L. Gavin, Deli Huang, Tanya R. Blane, Therese C. Thinnes, Yusuke Murakami, Ryutaro Fukui, Kensuke Miyake, David Nemazee
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/9f47727d2fa540ce8664019ff424400c
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:9f47727d2fa540ce8664019ff424400c
record_format	dspace
spelling	oai:doaj.org-article:9f47727d2fa540ce8664019ff424400c2021-12-02T18:37:16ZCleavage of DNA and RNA by PLD3 and PLD4 limits autoinflammatory triggering by multiple sensors10.1038/s41467-021-26150-w2041-1723https://doaj.org/article/9f47727d2fa540ce8664019ff424400c2021-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-26150-whttps://doaj.org/toc/2041-1723Loss of function polymorphisms of phospholipase D3 and D4 are associated with inflammatory diseases and their function is unclear. Here the authors show that PLD3/4 function as RNAses and deletion of these proteins in mice leads to accumulation of ssRNA which exacerbates inflammation through TLR signalling.Amanda L. GavinDeli HuangTanya R. BlaneTherese C. ThinnesYusuke MurakamiRyutaro FukuiKensuke MiyakeDavid NemazeeNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Amanda L. Gavin Deli Huang Tanya R. Blane Therese C. Thinnes Yusuke Murakami Ryutaro Fukui Kensuke Miyake David Nemazee Cleavage of DNA and RNA by PLD3 and PLD4 limits autoinflammatory triggering by multiple sensors
description	Loss of function polymorphisms of phospholipase D3 and D4 are associated with inflammatory diseases and their function is unclear. Here the authors show that PLD3/4 function as RNAses and deletion of these proteins in mice leads to accumulation of ssRNA which exacerbates inflammation through TLR signalling.
format	article
author	Amanda L. Gavin Deli Huang Tanya R. Blane Therese C. Thinnes Yusuke Murakami Ryutaro Fukui Kensuke Miyake David Nemazee
author_facet	Amanda L. Gavin Deli Huang Tanya R. Blane Therese C. Thinnes Yusuke Murakami Ryutaro Fukui Kensuke Miyake David Nemazee
author_sort	Amanda L. Gavin
title	Cleavage of DNA and RNA by PLD3 and PLD4 limits autoinflammatory triggering by multiple sensors
title_short	Cleavage of DNA and RNA by PLD3 and PLD4 limits autoinflammatory triggering by multiple sensors
title_full	Cleavage of DNA and RNA by PLD3 and PLD4 limits autoinflammatory triggering by multiple sensors
title_fullStr	Cleavage of DNA and RNA by PLD3 and PLD4 limits autoinflammatory triggering by multiple sensors
title_full_unstemmed	Cleavage of DNA and RNA by PLD3 and PLD4 limits autoinflammatory triggering by multiple sensors
title_sort	cleavage of dna and rna by pld3 and pld4 limits autoinflammatory triggering by multiple sensors
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/9f47727d2fa540ce8664019ff424400c
work_keys_str_mv	AT amandalgavin cleavageofdnaandrnabypld3andpld4limitsautoinflammatorytriggeringbymultiplesensors AT delihuang cleavageofdnaandrnabypld3andpld4limitsautoinflammatorytriggeringbymultiplesensors AT tanyarblane cleavageofdnaandrnabypld3andpld4limitsautoinflammatorytriggeringbymultiplesensors AT theresecthinnes cleavageofdnaandrnabypld3andpld4limitsautoinflammatorytriggeringbymultiplesensors AT yusukemurakami cleavageofdnaandrnabypld3andpld4limitsautoinflammatorytriggeringbymultiplesensors AT ryutarofukui cleavageofdnaandrnabypld3andpld4limitsautoinflammatorytriggeringbymultiplesensors AT kensukemiyake cleavageofdnaandrnabypld3andpld4limitsautoinflammatorytriggeringbymultiplesensors AT davidnemazee cleavageofdnaandrnabypld3andpld4limitsautoinflammatorytriggeringbymultiplesensors
_version_	1718377816027824128

Cleavage of DNA and RNA by PLD3 and PLD4 limits autoinflammatory triggering by multiple sensors

Ejemplares similares