Blood levels of stable nitric oxide metabolites in metabolic syndrome and diabetes mellitus

Aim. To measure stable metabolites of nitric oxide (SMNO), i.e. nitrites and nitrates, and compare the results with other biochemical characteristicsof blood in patients with type 1 and 2 diabetes mellitus (DM1 and DM2) or metabolic syndrome (MS). Materials and methods. The following parameters we...

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Autor principal:	Zulaykho Muralimzhanovna Shamansurova
Formato:	article
Lenguaje:	EN RU
Publicado:	Endocrinology Research Centre 2009
Materias:	type 1 and 2 diabetes mellitus nitric oxide endothelial dysfunction metabolic syndrome Nutritional diseases. Deficiency diseases RC620-627
Acceso en línea:	https://doaj.org/article/9f4fe386c8ac4db7affd5fc7e30a9ca2
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spelling	oai:doaj.org-article:9f4fe386c8ac4db7affd5fc7e30a9ca22021-11-14T09:00:14ZBlood levels of stable nitric oxide metabolites in metabolic syndrome and diabetes mellitus2072-03512072-037810.14341/2072-0351-5457https://doaj.org/article/9f4fe386c8ac4db7affd5fc7e30a9ca22009-09-01T00:00:00Zhttps://www.dia-endojournals.ru/jour/article/view/5457https://doaj.org/toc/2072-0351https://doaj.org/toc/2072-0378Aim. To measure stable metabolites of nitric oxide (SMNO), i.e. nitrites and nitrates, and compare the results with other biochemical characteristicsof blood in patients with type 1 and 2 diabetes mellitus (DM1 and DM2) or metabolic syndrome (MS). Materials and methods. The following parameters were measured in 61 patients with DM, 12 with obesity, 8 with impaired glucose tolerance (IGT),and 12 healthy subjects: blood glucose level (fasting and 2 hr postprandially), HbA1c, insulin, C-peptide, SMNO, lipid spectrum, erythrocyte sialidaseactivity (ESA), and insulin resistance index (HOMA). Results. Postprandial glycemia was elevated in DM1, DM2, and IGT patients, HOMA in those with DM2 and IGT, ESA in all DM and MS patients.SMNO level was reduced in all groups especially in patients with DM and diabetic nephropathy. It negatively correlated with total cholesterol, TG,LDL, and ESA. Conclusion. Blood SMNO level as an indicator of endothelial dysfunction is of high diagnostic value starting from the early stages of impaired carbohydratemetabolism.Zulaykho Muralimzhanovna ShamansurovaEndocrinology Research Centrearticletype 1 and 2 diabetes mellitusnitric oxideendothelial dysfunctionmetabolic syndromeNutritional diseases. Deficiency diseasesRC620-627ENRUСахарный диабет, Vol 12, Iss 3, Pp 71-74 (2009)
institution	DOAJ
collection	DOAJ
language	EN RU
topic	type 1 and 2 diabetes mellitus nitric oxide endothelial dysfunction metabolic syndrome Nutritional diseases. Deficiency diseases RC620-627
spellingShingle	type 1 and 2 diabetes mellitus nitric oxide endothelial dysfunction metabolic syndrome Nutritional diseases. Deficiency diseases RC620-627 Zulaykho Muralimzhanovna Shamansurova Blood levels of stable nitric oxide metabolites in metabolic syndrome and diabetes mellitus
description	Aim. To measure stable metabolites of nitric oxide (SMNO), i.e. nitrites and nitrates, and compare the results with other biochemical characteristicsof blood in patients with type 1 and 2 diabetes mellitus (DM1 and DM2) or metabolic syndrome (MS). Materials and methods. The following parameters were measured in 61 patients with DM, 12 with obesity, 8 with impaired glucose tolerance (IGT),and 12 healthy subjects: blood glucose level (fasting and 2 hr postprandially), HbA1c, insulin, C-peptide, SMNO, lipid spectrum, erythrocyte sialidaseactivity (ESA), and insulin resistance index (HOMA). Results. Postprandial glycemia was elevated in DM1, DM2, and IGT patients, HOMA in those with DM2 and IGT, ESA in all DM and MS patients.SMNO level was reduced in all groups especially in patients with DM and diabetic nephropathy. It negatively correlated with total cholesterol, TG,LDL, and ESA. Conclusion. Blood SMNO level as an indicator of endothelial dysfunction is of high diagnostic value starting from the early stages of impaired carbohydratemetabolism.
format	article
author	Zulaykho Muralimzhanovna Shamansurova
author_facet	Zulaykho Muralimzhanovna Shamansurova
author_sort	Zulaykho Muralimzhanovna Shamansurova
title	Blood levels of stable nitric oxide metabolites in metabolic syndrome and diabetes mellitus
title_short	Blood levels of stable nitric oxide metabolites in metabolic syndrome and diabetes mellitus
title_full	Blood levels of stable nitric oxide metabolites in metabolic syndrome and diabetes mellitus
title_fullStr	Blood levels of stable nitric oxide metabolites in metabolic syndrome and diabetes mellitus
title_full_unstemmed	Blood levels of stable nitric oxide metabolites in metabolic syndrome and diabetes mellitus
title_sort	blood levels of stable nitric oxide metabolites in metabolic syndrome and diabetes mellitus
publisher	Endocrinology Research Centre
publishDate	2009
url	https://doaj.org/article/9f4fe386c8ac4db7affd5fc7e30a9ca2
work_keys_str_mv	AT zulaykhomuralimzhanovnashamansurova bloodlevelsofstablenitricoxidemetabolitesinmetabolicsyndromeanddiabetesmellitus
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Blood levels of stable nitric oxide metabolites in metabolic syndrome and diabetes mellitus

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