Amphiphilic nanocarrier-induced modulation of PLK1 and miR-34a leads to improved therapeutic response in pancreatic cancer

Treatment of pancreatic ductal adenocarcinoma is still challenging and patients survival has only marginally improved in the last decade. Here the authors produce a PGA-based polymeric nanocarrier for the dual delivery of miR-34a-mimic and PLK1-targeting siRNA resulting in killing of pancreatic canc...

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Autores principales:	Hadas Gibori, Shay Eliyahu, Adva Krivitsky, Dikla Ben-Shushan, Yana Epshtein, Galia Tiram, Rachel Blau, Paula Ofek, Joo Sang Lee, Eytan Ruppin, Limor Landsman, Iris Barshack, Talia Golan, Emmanuelle Merquiol, Galia Blum, Ronit Satchi-Fainaro
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/9f5041d02f9946eea0f19af66fa313d8
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spelling	oai:doaj.org-article:9f5041d02f9946eea0f19af66fa313d82021-12-02T14:40:05ZAmphiphilic nanocarrier-induced modulation of PLK1 and miR-34a leads to improved therapeutic response in pancreatic cancer10.1038/s41467-017-02283-92041-1723https://doaj.org/article/9f5041d02f9946eea0f19af66fa313d82018-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02283-9https://doaj.org/toc/2041-1723Treatment of pancreatic ductal adenocarcinoma is still challenging and patients survival has only marginally improved in the last decade. Here the authors produce a PGA-based polymeric nanocarrier for the dual delivery of miR-34a-mimic and PLK1-targeting siRNA resulting in killing of pancreatic cancer cells in vivo.Hadas GiboriShay EliyahuAdva KrivitskyDikla Ben-ShushanYana EpshteinGalia TiramRachel BlauPaula OfekJoo Sang LeeEytan RuppinLimor LandsmanIris BarshackTalia GolanEmmanuelle MerquiolGalia BlumRonit Satchi-FainaroNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-18 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Hadas Gibori Shay Eliyahu Adva Krivitsky Dikla Ben-Shushan Yana Epshtein Galia Tiram Rachel Blau Paula Ofek Joo Sang Lee Eytan Ruppin Limor Landsman Iris Barshack Talia Golan Emmanuelle Merquiol Galia Blum Ronit Satchi-Fainaro Amphiphilic nanocarrier-induced modulation of PLK1 and miR-34a leads to improved therapeutic response in pancreatic cancer
description	Treatment of pancreatic ductal adenocarcinoma is still challenging and patients survival has only marginally improved in the last decade. Here the authors produce a PGA-based polymeric nanocarrier for the dual delivery of miR-34a-mimic and PLK1-targeting siRNA resulting in killing of pancreatic cancer cells in vivo.
format	article
author	Hadas Gibori Shay Eliyahu Adva Krivitsky Dikla Ben-Shushan Yana Epshtein Galia Tiram Rachel Blau Paula Ofek Joo Sang Lee Eytan Ruppin Limor Landsman Iris Barshack Talia Golan Emmanuelle Merquiol Galia Blum Ronit Satchi-Fainaro
author_facet	Hadas Gibori Shay Eliyahu Adva Krivitsky Dikla Ben-Shushan Yana Epshtein Galia Tiram Rachel Blau Paula Ofek Joo Sang Lee Eytan Ruppin Limor Landsman Iris Barshack Talia Golan Emmanuelle Merquiol Galia Blum Ronit Satchi-Fainaro
author_sort	Hadas Gibori
title	Amphiphilic nanocarrier-induced modulation of PLK1 and miR-34a leads to improved therapeutic response in pancreatic cancer
title_short	Amphiphilic nanocarrier-induced modulation of PLK1 and miR-34a leads to improved therapeutic response in pancreatic cancer
title_full	Amphiphilic nanocarrier-induced modulation of PLK1 and miR-34a leads to improved therapeutic response in pancreatic cancer
title_fullStr	Amphiphilic nanocarrier-induced modulation of PLK1 and miR-34a leads to improved therapeutic response in pancreatic cancer
title_full_unstemmed	Amphiphilic nanocarrier-induced modulation of PLK1 and miR-34a leads to improved therapeutic response in pancreatic cancer
title_sort	amphiphilic nanocarrier-induced modulation of plk1 and mir-34a leads to improved therapeutic response in pancreatic cancer
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/9f5041d02f9946eea0f19af66fa313d8
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Amphiphilic nanocarrier-induced modulation of PLK1 and miR-34a leads to improved therapeutic response in pancreatic cancer

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