Relationship of shear wave elastography anisotropy with tumor stem cells and epithelial-mesenchymal transition in breast cancer

Abstract Background This study is to examine the feasibility of shear wave elastography (SWE) anisotropy in assessing the prognosis of breast cancer. Methods We enrolled 119 breast cancer patients from January 2017 to October 2019. SWE was performed before operation. Emax (maximum elasticity value),...

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Autores principales:	Xiaoling Leng, Rexida Japaer, Haijian Zhang, Mila Yeerlan, Fucheng Ma, Jianbing Ding
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Anisotropy Breast cancer Cancer stem cells Epithelial-mesenchymal transition Shear wave elastography (SWE) Medical technology R855-855.5
Acceso en línea:	https://doaj.org/article/9f52827f90e6405c90998a33bf779554
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spelling	oai:doaj.org-article:9f52827f90e6405c90998a33bf7795542021-11-21T12:33:32ZRelationship of shear wave elastography anisotropy with tumor stem cells and epithelial-mesenchymal transition in breast cancer10.1186/s12880-021-00707-z1471-2342https://doaj.org/article/9f52827f90e6405c90998a33bf7795542021-11-01T00:00:00Zhttps://doi.org/10.1186/s12880-021-00707-zhttps://doaj.org/toc/1471-2342Abstract Background This study is to examine the feasibility of shear wave elastography (SWE) anisotropy in assessing the prognosis of breast cancer. Methods We enrolled 119 breast cancer patients from January 2017 to October 2019. SWE was performed before operation. Emax (maximum elasticity value), Emean (average elasticity value), Esd (standard deviation of the lesion elasticity value), Eratio (elasticity value of adipose tissue), anisotropy coefficient and difference were recorded. After operation, we collected clinical pathological data, and performed immunohistochemistry and real-time PCR tests on CD44, CD24, E-cadherin, β-catenin, vimentin and N-cadherin. Finally, we analyzed the correlation among parameters of SWE, anisotropy and clinicopathology, and markers of CSCs (cancer stem cells) and EMT (epithelial-mesenchymal transition). Results Emax, Emean and Esd of the cross section were higher than those of the longitudinal section. Breast cancer with a higher elastic modulus was often accompanied by a hyperechoic halo, which was manifested as mixed echo and post-echo attenuation, and was accompanied by a higher BI-RADS (breast imaging reporting and data system) classification. When breast cancer had hyperechoic halo and weakened posterior echo, SWE of the lesion showed more obvious anisotropy. In addition, larger diameter of the longitudinal section indicated higher stiffness of the cross section. Correlation analysis showed that E-cadherin was negatively correlated with SWE in longitudinal section. CD44, N-cadherin, β-catenin were positively correlated with SWE in longitudinal and cross sections. Vimentin and CD24 had no correlation with SWE parameters. Conclusion SWE of breast cancer is anisotropic. The cross-sectional SWE is better than the longitudinal SWE, Emax is better than Emean, the anisotropy of SWE is better than SWE, and the anisotropy factor is better than the anisotropy difference.Xiaoling LengRexida JapaerHaijian ZhangMila YeerlanFucheng MaJianbing DingBMCarticleAnisotropyBreast cancerCancer stem cellsEpithelial-mesenchymal transitionShear wave elastography (SWE)Medical technologyR855-855.5ENBMC Medical Imaging, Vol 21, Iss 1, Pp 1-16 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Anisotropy Breast cancer Cancer stem cells Epithelial-mesenchymal transition Shear wave elastography (SWE) Medical technology R855-855.5
spellingShingle	Anisotropy Breast cancer Cancer stem cells Epithelial-mesenchymal transition Shear wave elastography (SWE) Medical technology R855-855.5 Xiaoling Leng Rexida Japaer Haijian Zhang Mila Yeerlan Fucheng Ma Jianbing Ding Relationship of shear wave elastography anisotropy with tumor stem cells and epithelial-mesenchymal transition in breast cancer
description	Abstract Background This study is to examine the feasibility of shear wave elastography (SWE) anisotropy in assessing the prognosis of breast cancer. Methods We enrolled 119 breast cancer patients from January 2017 to October 2019. SWE was performed before operation. Emax (maximum elasticity value), Emean (average elasticity value), Esd (standard deviation of the lesion elasticity value), Eratio (elasticity value of adipose tissue), anisotropy coefficient and difference were recorded. After operation, we collected clinical pathological data, and performed immunohistochemistry and real-time PCR tests on CD44, CD24, E-cadherin, β-catenin, vimentin and N-cadherin. Finally, we analyzed the correlation among parameters of SWE, anisotropy and clinicopathology, and markers of CSCs (cancer stem cells) and EMT (epithelial-mesenchymal transition). Results Emax, Emean and Esd of the cross section were higher than those of the longitudinal section. Breast cancer with a higher elastic modulus was often accompanied by a hyperechoic halo, which was manifested as mixed echo and post-echo attenuation, and was accompanied by a higher BI-RADS (breast imaging reporting and data system) classification. When breast cancer had hyperechoic halo and weakened posterior echo, SWE of the lesion showed more obvious anisotropy. In addition, larger diameter of the longitudinal section indicated higher stiffness of the cross section. Correlation analysis showed that E-cadherin was negatively correlated with SWE in longitudinal section. CD44, N-cadherin, β-catenin were positively correlated with SWE in longitudinal and cross sections. Vimentin and CD24 had no correlation with SWE parameters. Conclusion SWE of breast cancer is anisotropic. The cross-sectional SWE is better than the longitudinal SWE, Emax is better than Emean, the anisotropy of SWE is better than SWE, and the anisotropy factor is better than the anisotropy difference.
format	article
author	Xiaoling Leng Rexida Japaer Haijian Zhang Mila Yeerlan Fucheng Ma Jianbing Ding
author_facet	Xiaoling Leng Rexida Japaer Haijian Zhang Mila Yeerlan Fucheng Ma Jianbing Ding
author_sort	Xiaoling Leng
title	Relationship of shear wave elastography anisotropy with tumor stem cells and epithelial-mesenchymal transition in breast cancer
title_short	Relationship of shear wave elastography anisotropy with tumor stem cells and epithelial-mesenchymal transition in breast cancer
title_full	Relationship of shear wave elastography anisotropy with tumor stem cells and epithelial-mesenchymal transition in breast cancer
title_fullStr	Relationship of shear wave elastography anisotropy with tumor stem cells and epithelial-mesenchymal transition in breast cancer
title_full_unstemmed	Relationship of shear wave elastography anisotropy with tumor stem cells and epithelial-mesenchymal transition in breast cancer
title_sort	relationship of shear wave elastography anisotropy with tumor stem cells and epithelial-mesenchymal transition in breast cancer
publisher	BMC
publishDate	2021
url	https://doaj.org/article/9f52827f90e6405c90998a33bf779554
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Relationship of shear wave elastography anisotropy with tumor stem cells and epithelial-mesenchymal transition in breast cancer

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