Optogenetic dissection of Rac1 and Cdc42 gradient shaping

A steep gradient of Cdc42 is at the front of migrating cells, whereas the active Rac1 gradient is graded. Here the authors show that Cdc42 gradients follow the distribution of GEFs and govern direction of migration, while Rac1 gradients require the activity of the GAP β2-chimaerin and control cell s...

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Autores principales:	S. de Beco, K. Vaidžiulytė, J. Manzi, F. Dalier, F. di Federico, G. Cornilleau, M. Dahan, M. Coppey
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/9f52b285dedc47c4bb66164b1c56ae12
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spelling	oai:doaj.org-article:9f52b285dedc47c4bb66164b1c56ae122021-12-02T15:33:38ZOptogenetic dissection of Rac1 and Cdc42 gradient shaping10.1038/s41467-018-07286-82041-1723https://doaj.org/article/9f52b285dedc47c4bb66164b1c56ae122018-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07286-8https://doaj.org/toc/2041-1723A steep gradient of Cdc42 is at the front of migrating cells, whereas the active Rac1 gradient is graded. Here the authors show that Cdc42 gradients follow the distribution of GEFs and govern direction of migration, while Rac1 gradients require the activity of the GAP β2-chimaerin and control cell speed.S. de BecoK. VaidžiulytėJ. ManziF. DalierF. di FedericoG. CornilleauM. DahanM. CoppeyNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q S. de Beco K. Vaidžiulytė J. Manzi F. Dalier F. di Federico G. Cornilleau M. Dahan M. Coppey Optogenetic dissection of Rac1 and Cdc42 gradient shaping
description	A steep gradient of Cdc42 is at the front of migrating cells, whereas the active Rac1 gradient is graded. Here the authors show that Cdc42 gradients follow the distribution of GEFs and govern direction of migration, while Rac1 gradients require the activity of the GAP β2-chimaerin and control cell speed.
format	article
author	S. de Beco K. Vaidžiulytė J. Manzi F. Dalier F. di Federico G. Cornilleau M. Dahan M. Coppey
author_facet	S. de Beco K. Vaidžiulytė J. Manzi F. Dalier F. di Federico G. Cornilleau M. Dahan M. Coppey
author_sort	S. de Beco
title	Optogenetic dissection of Rac1 and Cdc42 gradient shaping
title_short	Optogenetic dissection of Rac1 and Cdc42 gradient shaping
title_full	Optogenetic dissection of Rac1 and Cdc42 gradient shaping
title_fullStr	Optogenetic dissection of Rac1 and Cdc42 gradient shaping
title_full_unstemmed	Optogenetic dissection of Rac1 and Cdc42 gradient shaping
title_sort	optogenetic dissection of rac1 and cdc42 gradient shaping
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/9f52b285dedc47c4bb66164b1c56ae12
work_keys_str_mv	AT sdebeco optogeneticdissectionofrac1andcdc42gradientshaping AT kvaidziulyte optogeneticdissectionofrac1andcdc42gradientshaping AT jmanzi optogeneticdissectionofrac1andcdc42gradientshaping AT fdalier optogeneticdissectionofrac1andcdc42gradientshaping AT fdifederico optogeneticdissectionofrac1andcdc42gradientshaping AT gcornilleau optogeneticdissectionofrac1andcdc42gradientshaping AT mdahan optogeneticdissectionofrac1andcdc42gradientshaping AT mcoppey optogeneticdissectionofrac1andcdc42gradientshaping
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Optogenetic dissection of Rac1 and Cdc42 gradient shaping

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