Endothelin-1 supports clonal derivation and expansion of cardiovascular progenitors derived from human embryonic stem cells

Understanding coronary vessels development provides basis for regenerative strategies. Here, Soh et al. identify endothelin-1 as a key molecule driving long-term expansion of ISL1+bipotent vascular progenitors derived from human embryonic stem cells, and show that these cells can regenerate coronary...

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Autores principales:	Boon-Seng Soh, Shi-Yan Ng, Hao Wu, Kristina Buac, Joo-Hye C. Park, Xiaojun Lian, Jiejia Xu, Kylie S. Foo, Ulrika Felldin, Xiaobing He, Massimo Nichane, Henry Yang, Lei Bu, Ronald A. Li, Bing Lim, Kenneth R. Chien
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/9f548185f9ed4383938465a5168f1c5d
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spelling	oai:doaj.org-article:9f548185f9ed4383938465a5168f1c5d2021-12-02T16:56:47ZEndothelin-1 supports clonal derivation and expansion of cardiovascular progenitors derived from human embryonic stem cells10.1038/ncomms107742041-1723https://doaj.org/article/9f548185f9ed4383938465a5168f1c5d2016-03-01T00:00:00Zhttps://doi.org/10.1038/ncomms10774https://doaj.org/toc/2041-1723Understanding coronary vessels development provides basis for regenerative strategies. Here, Soh et al. identify endothelin-1 as a key molecule driving long-term expansion of ISL1+bipotent vascular progenitors derived from human embryonic stem cells, and show that these cells can regenerate coronary vessels in mice.Boon-Seng SohShi-Yan NgHao WuKristina BuacJoo-Hye C. ParkXiaojun LianJiejia XuKylie S. FooUlrika FelldinXiaobing HeMassimo NichaneHenry YangLei BuRonald A. LiBing LimKenneth R. ChienNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-11 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Boon-Seng Soh Shi-Yan Ng Hao Wu Kristina Buac Joo-Hye C. Park Xiaojun Lian Jiejia Xu Kylie S. Foo Ulrika Felldin Xiaobing He Massimo Nichane Henry Yang Lei Bu Ronald A. Li Bing Lim Kenneth R. Chien Endothelin-1 supports clonal derivation and expansion of cardiovascular progenitors derived from human embryonic stem cells
description	Understanding coronary vessels development provides basis for regenerative strategies. Here, Soh et al. identify endothelin-1 as a key molecule driving long-term expansion of ISL1+bipotent vascular progenitors derived from human embryonic stem cells, and show that these cells can regenerate coronary vessels in mice.
format	article
author	Boon-Seng Soh Shi-Yan Ng Hao Wu Kristina Buac Joo-Hye C. Park Xiaojun Lian Jiejia Xu Kylie S. Foo Ulrika Felldin Xiaobing He Massimo Nichane Henry Yang Lei Bu Ronald A. Li Bing Lim Kenneth R. Chien
author_facet	Boon-Seng Soh Shi-Yan Ng Hao Wu Kristina Buac Joo-Hye C. Park Xiaojun Lian Jiejia Xu Kylie S. Foo Ulrika Felldin Xiaobing He Massimo Nichane Henry Yang Lei Bu Ronald A. Li Bing Lim Kenneth R. Chien
author_sort	Boon-Seng Soh
title	Endothelin-1 supports clonal derivation and expansion of cardiovascular progenitors derived from human embryonic stem cells
title_short	Endothelin-1 supports clonal derivation and expansion of cardiovascular progenitors derived from human embryonic stem cells
title_full	Endothelin-1 supports clonal derivation and expansion of cardiovascular progenitors derived from human embryonic stem cells
title_fullStr	Endothelin-1 supports clonal derivation and expansion of cardiovascular progenitors derived from human embryonic stem cells
title_full_unstemmed	Endothelin-1 supports clonal derivation and expansion of cardiovascular progenitors derived from human embryonic stem cells
title_sort	endothelin-1 supports clonal derivation and expansion of cardiovascular progenitors derived from human embryonic stem cells
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/9f548185f9ed4383938465a5168f1c5d
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Endothelin-1 supports clonal derivation and expansion of cardiovascular progenitors derived from human embryonic stem cells

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