Transcriptional signature in microglia associated with Aβ plaque phagocytosis

Microglia associated with Aβ plaques may have a distinct transcriptional signature compared to those in plaque-free areas of the brain in Alzheimer’s disease (AD) models. Here the authors show that amyloid plaque phagocytosis is associated with a specific microglia transcriptional signature in a mou...

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Autores principales:	Alexandra Grubman, Xin Yi Choo, Gabriel Chew, John F. Ouyang, Guizhi Sun, Nathan P. Croft, Fernando J. Rossello, Rebecca Simmons, Sam Buckberry, Dulce Vargas Landin, Jahnvi Pflueger, Teresa H. Vandekolk, Zehra Abay, Yichen Zhou, Xiaodong Liu, Joseph Chen, Michael Larcombe, John M. Haynes, Catriona McLean, Sarah Williams, Siew Yeen Chai, Trevor Wilson, Ryan Lister, Colin W. Pouton, Anthony W. Purcell, Owen J. L. Rackham, Enrico Petretto, Jose M. Polo
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/9f55b1d1d77043558956af5abec4909b
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spelling	oai:doaj.org-article:9f55b1d1d77043558956af5abec4909b2021-12-02T14:58:43ZTranscriptional signature in microglia associated with Aβ plaque phagocytosis10.1038/s41467-021-23111-12041-1723https://doaj.org/article/9f55b1d1d77043558956af5abec4909b2021-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23111-1https://doaj.org/toc/2041-1723Microglia associated with Aβ plaques may have a distinct transcriptional signature compared to those in plaque-free areas of the brain in Alzheimer’s disease (AD) models. Here the authors show that amyloid plaque phagocytosis is associated with a specific microglia transcriptional signature in a mouse model of AD.Alexandra GrubmanXin Yi ChooGabriel ChewJohn F. OuyangGuizhi SunNathan P. CroftFernando J. RosselloRebecca SimmonsSam BuckberryDulce Vargas LandinJahnvi PfluegerTeresa H. VandekolkZehra AbayYichen ZhouXiaodong LiuJoseph ChenMichael LarcombeJohn M. HaynesCatriona McLeanSarah WilliamsSiew Yeen ChaiTrevor WilsonRyan ListerColin W. PoutonAnthony W. PurcellOwen J. L. RackhamEnrico PetrettoJose M. PoloNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-22 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Alexandra Grubman Xin Yi Choo Gabriel Chew John F. Ouyang Guizhi Sun Nathan P. Croft Fernando J. Rossello Rebecca Simmons Sam Buckberry Dulce Vargas Landin Jahnvi Pflueger Teresa H. Vandekolk Zehra Abay Yichen Zhou Xiaodong Liu Joseph Chen Michael Larcombe John M. Haynes Catriona McLean Sarah Williams Siew Yeen Chai Trevor Wilson Ryan Lister Colin W. Pouton Anthony W. Purcell Owen J. L. Rackham Enrico Petretto Jose M. Polo Transcriptional signature in microglia associated with Aβ plaque phagocytosis
description	Microglia associated with Aβ plaques may have a distinct transcriptional signature compared to those in plaque-free areas of the brain in Alzheimer’s disease (AD) models. Here the authors show that amyloid plaque phagocytosis is associated with a specific microglia transcriptional signature in a mouse model of AD.
format	article
author	Alexandra Grubman Xin Yi Choo Gabriel Chew John F. Ouyang Guizhi Sun Nathan P. Croft Fernando J. Rossello Rebecca Simmons Sam Buckberry Dulce Vargas Landin Jahnvi Pflueger Teresa H. Vandekolk Zehra Abay Yichen Zhou Xiaodong Liu Joseph Chen Michael Larcombe John M. Haynes Catriona McLean Sarah Williams Siew Yeen Chai Trevor Wilson Ryan Lister Colin W. Pouton Anthony W. Purcell Owen J. L. Rackham Enrico Petretto Jose M. Polo
author_facet	Alexandra Grubman Xin Yi Choo Gabriel Chew John F. Ouyang Guizhi Sun Nathan P. Croft Fernando J. Rossello Rebecca Simmons Sam Buckberry Dulce Vargas Landin Jahnvi Pflueger Teresa H. Vandekolk Zehra Abay Yichen Zhou Xiaodong Liu Joseph Chen Michael Larcombe John M. Haynes Catriona McLean Sarah Williams Siew Yeen Chai Trevor Wilson Ryan Lister Colin W. Pouton Anthony W. Purcell Owen J. L. Rackham Enrico Petretto Jose M. Polo
author_sort	Alexandra Grubman
title	Transcriptional signature in microglia associated with Aβ plaque phagocytosis
title_short	Transcriptional signature in microglia associated with Aβ plaque phagocytosis
title_full	Transcriptional signature in microglia associated with Aβ plaque phagocytosis
title_fullStr	Transcriptional signature in microglia associated with Aβ plaque phagocytosis
title_full_unstemmed	Transcriptional signature in microglia associated with Aβ plaque phagocytosis
title_sort	transcriptional signature in microglia associated with aβ plaque phagocytosis
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/9f55b1d1d77043558956af5abec4909b
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Transcriptional signature in microglia associated with Aβ plaque phagocytosis

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