Lateral Antimicrobial Resistance Genetic Transfer is active in the open environment

Abstract Historically, the environment has been viewed as a passive deposit of antimicrobial resistance mechanisms, where bacteria show biological cost for maintenance of these genes. Thus, in the absence of antimicrobial pressure, it is expected that they disappear from environmental bacterial comm...

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Autores principales:	Luciana S. Chamosa, Verónica E. Álvarez, Maximiliano Nardelli, María Paula Quiroga, Marcelo H. Cassini, Daniela Centrón
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/9f5771f16e0d433a8cfc9f588043c00e
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spelling	oai:doaj.org-article:9f5771f16e0d433a8cfc9f588043c00e2021-12-02T15:18:52ZLateral Antimicrobial Resistance Genetic Transfer is active in the open environment10.1038/s41598-017-00600-22045-2322https://doaj.org/article/9f5771f16e0d433a8cfc9f588043c00e2017-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-00600-2https://doaj.org/toc/2045-2322Abstract Historically, the environment has been viewed as a passive deposit of antimicrobial resistance mechanisms, where bacteria show biological cost for maintenance of these genes. Thus, in the absence of antimicrobial pressure, it is expected that they disappear from environmental bacterial communities. To test this scenario, we studied native IntI1 functionality of 11 class 1 integron-positive environmental strains of distant genera collected in cold and subtropical forests of Argentina. We found natural competence and successful site-specific insertion with no significant fitness cost of both aadB and bla VIM-2 antimicrobial resistance gene cassettes, in a model system without antibiotic pressure. A bidirectional flow of antimicrobial resistance gene cassettes between natural and nosocomial habitats is proposed, which implies an active role of the open environment as a reservoir, recipient and source of antimicrobial resistance mechanisms, outlining an environmental threat where novel concepts of rational use of antibiotics are extremely urgent and mandatory.Luciana S. ChamosaVerónica E. ÁlvarezMaximiliano NardelliMaría Paula QuirogaMarcelo H. CassiniDaniela CentrónNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Luciana S. Chamosa Verónica E. Álvarez Maximiliano Nardelli María Paula Quiroga Marcelo H. Cassini Daniela Centrón Lateral Antimicrobial Resistance Genetic Transfer is active in the open environment
description	Abstract Historically, the environment has been viewed as a passive deposit of antimicrobial resistance mechanisms, where bacteria show biological cost for maintenance of these genes. Thus, in the absence of antimicrobial pressure, it is expected that they disappear from environmental bacterial communities. To test this scenario, we studied native IntI1 functionality of 11 class 1 integron-positive environmental strains of distant genera collected in cold and subtropical forests of Argentina. We found natural competence and successful site-specific insertion with no significant fitness cost of both aadB and bla VIM-2 antimicrobial resistance gene cassettes, in a model system without antibiotic pressure. A bidirectional flow of antimicrobial resistance gene cassettes between natural and nosocomial habitats is proposed, which implies an active role of the open environment as a reservoir, recipient and source of antimicrobial resistance mechanisms, outlining an environmental threat where novel concepts of rational use of antibiotics are extremely urgent and mandatory.
format	article
author	Luciana S. Chamosa Verónica E. Álvarez Maximiliano Nardelli María Paula Quiroga Marcelo H. Cassini Daniela Centrón
author_facet	Luciana S. Chamosa Verónica E. Álvarez Maximiliano Nardelli María Paula Quiroga Marcelo H. Cassini Daniela Centrón
author_sort	Luciana S. Chamosa
title	Lateral Antimicrobial Resistance Genetic Transfer is active in the open environment
title_short	Lateral Antimicrobial Resistance Genetic Transfer is active in the open environment
title_full	Lateral Antimicrobial Resistance Genetic Transfer is active in the open environment
title_fullStr	Lateral Antimicrobial Resistance Genetic Transfer is active in the open environment
title_full_unstemmed	Lateral Antimicrobial Resistance Genetic Transfer is active in the open environment
title_sort	lateral antimicrobial resistance genetic transfer is active in the open environment
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/9f5771f16e0d433a8cfc9f588043c00e
work_keys_str_mv	AT lucianaschamosa lateralantimicrobialresistancegenetictransferisactiveintheopenenvironment AT veronicaealvarez lateralantimicrobialresistancegenetictransferisactiveintheopenenvironment AT maximilianonardelli lateralantimicrobialresistancegenetictransferisactiveintheopenenvironment AT mariapaulaquiroga lateralantimicrobialresistancegenetictransferisactiveintheopenenvironment AT marcelohcassini lateralantimicrobialresistancegenetictransferisactiveintheopenenvironment AT danielacentron lateralantimicrobialresistancegenetictransferisactiveintheopenenvironment
_version_	1718387464818655232

Lateral Antimicrobial Resistance Genetic Transfer is active in the open environment

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