CHEMOKINE SECRETION PATTERNS IN MONONUCLEAR AND DENDRITIC CELLS: ROLE OF HISTAMINE TYPE H3/H4 RECEPTORS

The study presents results concerning effects of H3/H4 histamine receptors antagonist (Ciproxifan) upon in vitro chemokine secretion by dendritic cells (DC) and peripheral blood mononuclear cells (PBMC). We have been shown that in vitro inhibition of type H3/H4 histamine receptor affects in differen...

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Autores principales:	V. S. Evstratova, N. A. Riger, D. B. Nikityuk, R. A. Khanferyan
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2016
Materias:	chemokines cytokines histamine receptors immunity dendritic cells peripheral blood mononuclear cells Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/9f584ea123364b37888471839904cf8e
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spelling	oai:doaj.org-article:9f584ea123364b37888471839904cf8e2021-11-18T08:03:45ZCHEMOKINE SECRETION PATTERNS IN MONONUCLEAR AND DENDRITIC CELLS: ROLE OF HISTAMINE TYPE H3/H4 RECEPTORS1563-06252313-741X10.15789/1563-0625-2016-5-437-442https://doaj.org/article/9f584ea123364b37888471839904cf8e2016-08-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/1067https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XThe study presents results concerning effects of H3/H4 histamine receptors antagonist (Ciproxifan) upon in vitro chemokine secretion by dendritic cells (DC) and peripheral blood mononuclear cells (PBMC). We have been shown that in vitro inhibition of type H3/H4 histamine receptor affects in different ways production of major chemokines by PBMC and DC, including eotaxin, RANTES, MCP-1, MIP-1α, MIP-1β, GRO-α, and IL-8. E.g., RANTES and GRO-α secretion in DC cultures was reduced, respectively, by 20% and 40%. Meanwhile, MIP-1β secretion was virtually unchanged, whereas MCP-1 secretion exhibited a four-fold increase. In PBMC cultures, the H3/H4 receptor antagonist induced a significant increase in eotaxin, RANTES, MIP-1α, MIP-1β, GRO-α, and IL-8 secretion (p < 0.05).V. S. EvstratovaN. A. RigerD. B. NikityukR. A. KhanferyanSPb RAACIarticlechemokinescytokineshistamine receptorsimmunitydendritic cellsperipheral blood mononuclear cellsImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 18, Iss 5, Pp 437-442 (2016)
institution	DOAJ
collection	DOAJ
language	RU
topic	chemokines cytokines histamine receptors immunity dendritic cells peripheral blood mononuclear cells Immunologic diseases. Allergy RC581-607
spellingShingle	chemokines cytokines histamine receptors immunity dendritic cells peripheral blood mononuclear cells Immunologic diseases. Allergy RC581-607 V. S. Evstratova N. A. Riger D. B. Nikityuk R. A. Khanferyan CHEMOKINE SECRETION PATTERNS IN MONONUCLEAR AND DENDRITIC CELLS: ROLE OF HISTAMINE TYPE H3/H4 RECEPTORS
description	The study presents results concerning effects of H3/H4 histamine receptors antagonist (Ciproxifan) upon in vitro chemokine secretion by dendritic cells (DC) and peripheral blood mononuclear cells (PBMC). We have been shown that in vitro inhibition of type H3/H4 histamine receptor affects in different ways production of major chemokines by PBMC and DC, including eotaxin, RANTES, MCP-1, MIP-1α, MIP-1β, GRO-α, and IL-8. E.g., RANTES and GRO-α secretion in DC cultures was reduced, respectively, by 20% and 40%. Meanwhile, MIP-1β secretion was virtually unchanged, whereas MCP-1 secretion exhibited a four-fold increase. In PBMC cultures, the H3/H4 receptor antagonist induced a significant increase in eotaxin, RANTES, MIP-1α, MIP-1β, GRO-α, and IL-8 secretion (p < 0.05).
format	article
author	V. S. Evstratova N. A. Riger D. B. Nikityuk R. A. Khanferyan
author_facet	V. S. Evstratova N. A. Riger D. B. Nikityuk R. A. Khanferyan
author_sort	V. S. Evstratova
title	CHEMOKINE SECRETION PATTERNS IN MONONUCLEAR AND DENDRITIC CELLS: ROLE OF HISTAMINE TYPE H3/H4 RECEPTORS
title_short	CHEMOKINE SECRETION PATTERNS IN MONONUCLEAR AND DENDRITIC CELLS: ROLE OF HISTAMINE TYPE H3/H4 RECEPTORS
title_full	CHEMOKINE SECRETION PATTERNS IN MONONUCLEAR AND DENDRITIC CELLS: ROLE OF HISTAMINE TYPE H3/H4 RECEPTORS
title_fullStr	CHEMOKINE SECRETION PATTERNS IN MONONUCLEAR AND DENDRITIC CELLS: ROLE OF HISTAMINE TYPE H3/H4 RECEPTORS
title_full_unstemmed	CHEMOKINE SECRETION PATTERNS IN MONONUCLEAR AND DENDRITIC CELLS: ROLE OF HISTAMINE TYPE H3/H4 RECEPTORS
title_sort	chemokine secretion patterns in mononuclear and dendritic cells: role of histamine type h3/h4 receptors
publisher	SPb RAACI
publishDate	2016
url	https://doaj.org/article/9f584ea123364b37888471839904cf8e
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CHEMOKINE SECRETION PATTERNS IN MONONUCLEAR AND DENDRITIC CELLS: ROLE OF HISTAMINE TYPE H3/H4 RECEPTORS

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