Amplification of USP13 drives ovarian cancer metabolism

Amplification of USP13 drives ovarian cancer metabolism

Cancer cells need to reprogramme their metabolism to allow rapid cell proliferation. Here, the authors show that USP13is amplified in ovarian cancer and its protein product, a deubiquitinase, drives tumour progression by rewiring the metabolism of cancer cells by stabilising two critical metabolic e...

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Autores principales: Cecil Han, Lifeng Yang, Hyun Ho Choi, Joelle Baddour, Abhinav Achreja, Yunhua Liu, Yujing Li, Jiada Li, Guohui Wan, Cheng Huang, Guang Ji, Xinna Zhang, Deepak Nagrath, Xiongbin Lu
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
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Q
Acceso en línea:https://doaj.org/article/9f59e46f1c304a21970cdebfb358fc87
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spelling oai:doaj.org-article:9f59e46f1c304a21970cdebfb358fc872021-12-02T16:49:57ZAmplification of USP13 drives ovarian cancer metabolism10.1038/ncomms135252041-1723https://doaj.org/article/9f59e46f1c304a21970cdebfb358fc872016-11-01T00:00:00Zhttps://doi.org/10.1038/ncomms13525https://doaj.org/toc/2041-1723Cancer cells need to reprogramme their metabolism to allow rapid cell proliferation. Here, the authors show that USP13is amplified in ovarian cancer and its protein product, a deubiquitinase, drives tumour progression by rewiring the metabolism of cancer cells by stabilising two critical metabolic enzymes.Cecil HanLifeng YangHyun Ho ChoiJoelle BaddourAbhinav AchrejaYunhua LiuYujing LiJiada LiGuohui WanCheng HuangGuang JiXinna ZhangDeepak NagrathXiongbin LuNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-16 (2016)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Cecil Han
Lifeng Yang
Hyun Ho Choi
Joelle Baddour
Abhinav Achreja
Yunhua Liu
Yujing Li
Jiada Li
Guohui Wan
Cheng Huang
Guang Ji
Xinna Zhang
Deepak Nagrath
Xiongbin Lu
Amplification of USP13 drives ovarian cancer metabolism
description Cancer cells need to reprogramme their metabolism to allow rapid cell proliferation. Here, the authors show that USP13is amplified in ovarian cancer and its protein product, a deubiquitinase, drives tumour progression by rewiring the metabolism of cancer cells by stabilising two critical metabolic enzymes.
format article
author Cecil Han
Lifeng Yang
Hyun Ho Choi
Joelle Baddour
Abhinav Achreja
Yunhua Liu
Yujing Li
Jiada Li
Guohui Wan
Cheng Huang
Guang Ji
Xinna Zhang
Deepak Nagrath
Xiongbin Lu
author_facet Cecil Han
Lifeng Yang
Hyun Ho Choi
Joelle Baddour
Abhinav Achreja
Yunhua Liu
Yujing Li
Jiada Li
Guohui Wan
Cheng Huang
Guang Ji
Xinna Zhang
Deepak Nagrath
Xiongbin Lu
author_sort Cecil Han
title Amplification of USP13 drives ovarian cancer metabolism
title_short Amplification of USP13 drives ovarian cancer metabolism
title_full Amplification of USP13 drives ovarian cancer metabolism
title_fullStr Amplification of USP13 drives ovarian cancer metabolism
title_full_unstemmed Amplification of USP13 drives ovarian cancer metabolism
title_sort amplification of usp13 drives ovarian cancer metabolism
publisher Nature Portfolio
publishDate 2016
url https://doaj.org/article/9f59e46f1c304a21970cdebfb358fc87
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AT lifengyang amplificationofusp13drivesovariancancermetabolism
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