Poly(ADP-ribose) polymerase-1 antagonizes DNA resection at double-strand breaks

Poly(ADP-ribose) polymerase-1 (PARP-1) facilitates local chromatin relaxation and the recruitment of DNA repair factors at double strand breaks site (DSBs). Here the authors reveal that PARP-1 acts as a critical regulator of DNA end resection of DSBs.

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Autores principales:	Marie-Christine Caron, Ajit K. Sharma, Julia O’Sullivan, Logan R. Myler, Maria Tedim Ferreira, Amélie Rodrigue, Yan Coulombe, Chantal Ethier, Jean-Philippe Gagné, Marie-France Langelier, John M. Pascal, Ilya J. Finkelstein, Michael J. Hendzel, Guy G. Poirier, Jean-Yves Masson
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/9f5d756d157a42a383cdfc2eb5b3e5f7
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

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spelling	oai:doaj.org-article:9f5d756d157a42a383cdfc2eb5b3e5f72021-12-02T16:58:25ZPoly(ADP-ribose) polymerase-1 antagonizes DNA resection at double-strand breaks10.1038/s41467-019-10741-92041-1723https://doaj.org/article/9f5d756d157a42a383cdfc2eb5b3e5f72019-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10741-9https://doaj.org/toc/2041-1723Poly(ADP-ribose) polymerase-1 (PARP-1) facilitates local chromatin relaxation and the recruitment of DNA repair factors at double strand breaks site (DSBs). Here the authors reveal that PARP-1 acts as a critical regulator of DNA end resection of DSBs.Marie-Christine CaronAjit K. SharmaJulia O’SullivanLogan R. MylerMaria Tedim FerreiraAmélie RodrigueYan CoulombeChantal EthierJean-Philippe GagnéMarie-France LangelierJohn M. PascalIlya J. FinkelsteinMichael J. HendzelGuy G. PoirierJean-Yves MassonNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Marie-Christine Caron Ajit K. Sharma Julia O’Sullivan Logan R. Myler Maria Tedim Ferreira Amélie Rodrigue Yan Coulombe Chantal Ethier Jean-Philippe Gagné Marie-France Langelier John M. Pascal Ilya J. Finkelstein Michael J. Hendzel Guy G. Poirier Jean-Yves Masson Poly(ADP-ribose) polymerase-1 antagonizes DNA resection at double-strand breaks
description	Poly(ADP-ribose) polymerase-1 (PARP-1) facilitates local chromatin relaxation and the recruitment of DNA repair factors at double strand breaks site (DSBs). Here the authors reveal that PARP-1 acts as a critical regulator of DNA end resection of DSBs.
format	article
author	Marie-Christine Caron Ajit K. Sharma Julia O’Sullivan Logan R. Myler Maria Tedim Ferreira Amélie Rodrigue Yan Coulombe Chantal Ethier Jean-Philippe Gagné Marie-France Langelier John M. Pascal Ilya J. Finkelstein Michael J. Hendzel Guy G. Poirier Jean-Yves Masson
author_facet	Marie-Christine Caron Ajit K. Sharma Julia O’Sullivan Logan R. Myler Maria Tedim Ferreira Amélie Rodrigue Yan Coulombe Chantal Ethier Jean-Philippe Gagné Marie-France Langelier John M. Pascal Ilya J. Finkelstein Michael J. Hendzel Guy G. Poirier Jean-Yves Masson
author_sort	Marie-Christine Caron
title	Poly(ADP-ribose) polymerase-1 antagonizes DNA resection at double-strand breaks
title_short	Poly(ADP-ribose) polymerase-1 antagonizes DNA resection at double-strand breaks
title_full	Poly(ADP-ribose) polymerase-1 antagonizes DNA resection at double-strand breaks
title_fullStr	Poly(ADP-ribose) polymerase-1 antagonizes DNA resection at double-strand breaks
title_full_unstemmed	Poly(ADP-ribose) polymerase-1 antagonizes DNA resection at double-strand breaks
title_sort	poly(adp-ribose) polymerase-1 antagonizes dna resection at double-strand breaks
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/9f5d756d157a42a383cdfc2eb5b3e5f7
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Poly(ADP-ribose) polymerase-1 antagonizes DNA resection at double-strand breaks

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