Poly(ADP-ribose) polymerase-1 antagonizes DNA resection at double-strand breaks

Poly(ADP-ribose) polymerase-1 antagonizes DNA resection at double-strand breaks

Poly(ADP-ribose) polymerase-1 (PARP-1) facilitates local chromatin relaxation and the recruitment of DNA repair factors at double strand breaks site (DSBs). Here the authors reveal that PARP-1 acts as a critical regulator of DNA end resection of DSBs.

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Detalles Bibliográficos
Autores principales: Marie-Christine Caron, Ajit K. Sharma, Julia O’Sullivan, Logan R. Myler, Maria Tedim Ferreira, Amélie Rodrigue, Yan Coulombe, Chantal Ethier, Jean-Philippe Gagné, Marie-France Langelier, John M. Pascal, Ilya J. Finkelstein, Michael J. Hendzel, Guy G. Poirier, Jean-Yves Masson
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
Materias:
Science
Q
Acceso en línea:https://doaj.org/article/9f5d756d157a42a383cdfc2eb5b3e5f7
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