REEP5 depletion causes sarco-endoplasmic reticulum vacuolization and cardiac functional defects

The sarcoplasmic (SR) and endoplasmic reticulum (ER) are involved in heart development but how this arises is unclear. Here, the authors show that loss of a SR/ER protein REEP5 causes membrane destabilization and decreased cardiac myocyte contractility, with cardiac dysfunction in mutant mouse and z...

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Autores principales:	Shin-Haw Lee, Sina Hadipour-Lakmehsari, Harsha R. Murthy, Natalie Gibb, Tetsuaki Miyake, Allen C. T. Teng, Jake Cosme, Jessica C. Yu, Mark Moon, SangHyun Lim, Victoria Wong, Peter Liu, Filio Billia, Rodrigo Fernandez-Gonzalez, Igor Stagljar, Parveen Sharma, Thomas Kislinger, Ian C. Scott, Anthony O. Gramolini
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/9f62361bf8a34f7da79df62e9762126b
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spelling	oai:doaj.org-article:9f62361bf8a34f7da79df62e9762126b2021-12-02T14:40:50ZREEP5 depletion causes sarco-endoplasmic reticulum vacuolization and cardiac functional defects10.1038/s41467-019-14143-92041-1723https://doaj.org/article/9f62361bf8a34f7da79df62e9762126b2020-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-14143-9https://doaj.org/toc/2041-1723The sarcoplasmic (SR) and endoplasmic reticulum (ER) are involved in heart development but how this arises is unclear. Here, the authors show that loss of a SR/ER protein REEP5 causes membrane destabilization and decreased cardiac myocyte contractility, with cardiac dysfunction in mutant mouse and zebrafish models.Shin-Haw LeeSina Hadipour-LakmehsariHarsha R. MurthyNatalie GibbTetsuaki MiyakeAllen C. T. TengJake CosmeJessica C. YuMark MoonSangHyun LimVictoria WongPeter LiuFilio BilliaRodrigo Fernandez-GonzalezIgor StagljarParveen SharmaThomas KislingerIan C. ScottAnthony O. GramoliniNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-20 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Shin-Haw Lee Sina Hadipour-Lakmehsari Harsha R. Murthy Natalie Gibb Tetsuaki Miyake Allen C. T. Teng Jake Cosme Jessica C. Yu Mark Moon SangHyun Lim Victoria Wong Peter Liu Filio Billia Rodrigo Fernandez-Gonzalez Igor Stagljar Parveen Sharma Thomas Kislinger Ian C. Scott Anthony O. Gramolini REEP5 depletion causes sarco-endoplasmic reticulum vacuolization and cardiac functional defects
description	The sarcoplasmic (SR) and endoplasmic reticulum (ER) are involved in heart development but how this arises is unclear. Here, the authors show that loss of a SR/ER protein REEP5 causes membrane destabilization and decreased cardiac myocyte contractility, with cardiac dysfunction in mutant mouse and zebrafish models.
format	article
author	Shin-Haw Lee Sina Hadipour-Lakmehsari Harsha R. Murthy Natalie Gibb Tetsuaki Miyake Allen C. T. Teng Jake Cosme Jessica C. Yu Mark Moon SangHyun Lim Victoria Wong Peter Liu Filio Billia Rodrigo Fernandez-Gonzalez Igor Stagljar Parveen Sharma Thomas Kislinger Ian C. Scott Anthony O. Gramolini
author_facet	Shin-Haw Lee Sina Hadipour-Lakmehsari Harsha R. Murthy Natalie Gibb Tetsuaki Miyake Allen C. T. Teng Jake Cosme Jessica C. Yu Mark Moon SangHyun Lim Victoria Wong Peter Liu Filio Billia Rodrigo Fernandez-Gonzalez Igor Stagljar Parveen Sharma Thomas Kislinger Ian C. Scott Anthony O. Gramolini
author_sort	Shin-Haw Lee
title	REEP5 depletion causes sarco-endoplasmic reticulum vacuolization and cardiac functional defects
title_short	REEP5 depletion causes sarco-endoplasmic reticulum vacuolization and cardiac functional defects
title_full	REEP5 depletion causes sarco-endoplasmic reticulum vacuolization and cardiac functional defects
title_fullStr	REEP5 depletion causes sarco-endoplasmic reticulum vacuolization and cardiac functional defects
title_full_unstemmed	REEP5 depletion causes sarco-endoplasmic reticulum vacuolization and cardiac functional defects
title_sort	reep5 depletion causes sarco-endoplasmic reticulum vacuolization and cardiac functional defects
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/9f62361bf8a34f7da79df62e9762126b
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REEP5 depletion causes sarco-endoplasmic reticulum vacuolization and cardiac functional defects

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