Predictive Role of Targeted, Active Surveillance Cultures for Detection of Methicillin-Resistant Staphylococcus aureus

Safiya Al Musawi,1 Qassim Alkhaleefa,2 Samia Alnassri,3 Aisha Alamri,4 Amani Alnimr2 1Department of Pathology, Salmaniya Medical Complex, Ministry of Health, Manama, Kingdom of Bahrain; 2Department of Microbiology, College of Medicine, Imam Abdulrahman Bin Faisal University, Dammam, Kingdom of Saudi...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Al Musawi S, Alkhaleefa Q, Alnassri S, Alamri A, Alnimr A
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	methicillin-resistant staphylococcus aureus screening sites infection control saudi arabia Infectious and parasitic diseases RC109-216
Acceso en línea:	https://doaj.org/article/9f6436db5a084401aece8c998f21a6e8
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:9f6436db5a084401aece8c998f21a6e8
record_format	dspace
spelling	oai:doaj.org-article:9f6436db5a084401aece8c998f21a6e82021-11-14T19:00:30ZPredictive Role of Targeted, Active Surveillance Cultures for Detection of Methicillin-Resistant Staphylococcus aureus1178-6973https://doaj.org/article/9f6436db5a084401aece8c998f21a6e82021-11-01T00:00:00Zhttps://www.dovepress.com/predictive-role-of-targeted-active-surveillance-cultures-for-detection-peer-reviewed-fulltext-article-IDRhttps://doaj.org/toc/1178-6973Safiya Al Musawi,1 Qassim Alkhaleefa,2 Samia Alnassri,3 Aisha Alamri,4 Amani Alnimr2 1Department of Pathology, Salmaniya Medical Complex, Ministry of Health, Manama, Kingdom of Bahrain; 2Department of Microbiology, College of Medicine, Imam Abdulrahman Bin Faisal University, Dammam, Kingdom of Saudi Arabia; 3Department of Infection Control, King Fahad Hospital of the University, Dammam, Kingdom of Saudi Arabia; 4Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, Imam Abdulrahman Bin Faisal University, Dammam, Kingdom of Saudi ArabiaCorrespondence: Amani AlnimrDepartment of Microbiology, College of Medicine, Imam Abdul Rahman Bin Faisal University, P.O. Box 1982, Dammam, 31441, Kingdom of Saudi ArabiaTel +966 56 318 1019Email amalnimr@iau.edu.saAisha AlamriDepartment of Clinical Laboratory Sciences, College of Applied Medical Sciences, Imam Abdul Rahman Bin Faisal University, Dammam, 3144, Kingdom of Saudi ArabiaTel +966 538187263Email aiamri@iau.edu.saIntroduction: Methicillin-resistant Staphylococcus aureus (MRSA) colonisation is an important source of healthcare-acquired infections. Reliable screening strategies for MRSA colonisation are essential for the timely implementation of infection control measures.Aim: This study determined reliable MRSA screening sites to predict colonisation in resource-limited settings and estimated the impact of missed MRSA cases when shifting from multi- to single-site screening.Methodology: A cross-sectional study was conducted in patients with positive MRSA surveillance cultures from the routinely screened sites (nasal, axillary, groin, and throat) from January 2009 to December 2019.Results: A total of 1906 screening tests were positive for MRSA cultures (n = 1345 patients). As a single site, the nasal cavity showed the highest MRSA detection, with a sensitivity of 66.8% (95% CI = 64– 69) with 277.9 missed isolation days. Screening three or more anatomical sites detected 97– 100% of MRSA cases, with 0– 24.5 missed isolation days. Screening the axilla and groin separately or in combination showed a good clinical utility index (CUI) of > 0.6 to < 0.8, while an excellent CUI was obtained upon screening other site samples (> 0.8). The combined nasal and throat cultures demonstrated a sensitivity of 93.2 (95% CI = 91– 94) with 57.2 missed isolation days.Conclusion: Multi-site screening is the optimal strategy for minimising MRSA exposure within a healthcare facility. For active MRSA surveillance, a combination of nasal and throat cultures can provide a practical approach in low-resource settings compared to nasal sampling alone.Keywords: methicillin-resistant Staphylococcus aureus, screening sites, infection control, Saudi ArabiaAl Musawi SAlkhaleefa QAlnassri SAlamri AAlnimr ADove Medical Pressarticlemethicillin-resistant staphylococcus aureusscreening sitesinfection controlsaudi arabiaInfectious and parasitic diseasesRC109-216ENInfection and Drug Resistance, Vol Volume 14, Pp 4757-4764 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	methicillin-resistant staphylococcus aureus screening sites infection control saudi arabia Infectious and parasitic diseases RC109-216
spellingShingle	methicillin-resistant staphylococcus aureus screening sites infection control saudi arabia Infectious and parasitic diseases RC109-216 Al Musawi S Alkhaleefa Q Alnassri S Alamri A Alnimr A Predictive Role of Targeted, Active Surveillance Cultures for Detection of Methicillin-Resistant Staphylococcus aureus
description	Safiya Al Musawi,1 Qassim Alkhaleefa,2 Samia Alnassri,3 Aisha Alamri,4 Amani Alnimr2 1Department of Pathology, Salmaniya Medical Complex, Ministry of Health, Manama, Kingdom of Bahrain; 2Department of Microbiology, College of Medicine, Imam Abdulrahman Bin Faisal University, Dammam, Kingdom of Saudi Arabia; 3Department of Infection Control, King Fahad Hospital of the University, Dammam, Kingdom of Saudi Arabia; 4Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, Imam Abdulrahman Bin Faisal University, Dammam, Kingdom of Saudi ArabiaCorrespondence: Amani AlnimrDepartment of Microbiology, College of Medicine, Imam Abdul Rahman Bin Faisal University, P.O. Box 1982, Dammam, 31441, Kingdom of Saudi ArabiaTel +966 56 318 1019Email amalnimr@iau.edu.saAisha AlamriDepartment of Clinical Laboratory Sciences, College of Applied Medical Sciences, Imam Abdul Rahman Bin Faisal University, Dammam, 3144, Kingdom of Saudi ArabiaTel +966 538187263Email aiamri@iau.edu.saIntroduction: Methicillin-resistant Staphylococcus aureus (MRSA) colonisation is an important source of healthcare-acquired infections. Reliable screening strategies for MRSA colonisation are essential for the timely implementation of infection control measures.Aim: This study determined reliable MRSA screening sites to predict colonisation in resource-limited settings and estimated the impact of missed MRSA cases when shifting from multi- to single-site screening.Methodology: A cross-sectional study was conducted in patients with positive MRSA surveillance cultures from the routinely screened sites (nasal, axillary, groin, and throat) from January 2009 to December 2019.Results: A total of 1906 screening tests were positive for MRSA cultures (n = 1345 patients). As a single site, the nasal cavity showed the highest MRSA detection, with a sensitivity of 66.8% (95% CI = 64– 69) with 277.9 missed isolation days. Screening three or more anatomical sites detected 97– 100% of MRSA cases, with 0– 24.5 missed isolation days. Screening the axilla and groin separately or in combination showed a good clinical utility index (CUI) of > 0.6 to < 0.8, while an excellent CUI was obtained upon screening other site samples (> 0.8). The combined nasal and throat cultures demonstrated a sensitivity of 93.2 (95% CI = 91– 94) with 57.2 missed isolation days.Conclusion: Multi-site screening is the optimal strategy for minimising MRSA exposure within a healthcare facility. For active MRSA surveillance, a combination of nasal and throat cultures can provide a practical approach in low-resource settings compared to nasal sampling alone.Keywords: methicillin-resistant Staphylococcus aureus, screening sites, infection control, Saudi Arabia
format	article
author	Al Musawi S Alkhaleefa Q Alnassri S Alamri A Alnimr A
author_facet	Al Musawi S Alkhaleefa Q Alnassri S Alamri A Alnimr A
author_sort	Al Musawi S
title	Predictive Role of Targeted, Active Surveillance Cultures for Detection of Methicillin-Resistant Staphylococcus aureus
title_short	Predictive Role of Targeted, Active Surveillance Cultures for Detection of Methicillin-Resistant Staphylococcus aureus
title_full	Predictive Role of Targeted, Active Surveillance Cultures for Detection of Methicillin-Resistant Staphylococcus aureus
title_fullStr	Predictive Role of Targeted, Active Surveillance Cultures for Detection of Methicillin-Resistant Staphylococcus aureus
title_full_unstemmed	Predictive Role of Targeted, Active Surveillance Cultures for Detection of Methicillin-Resistant Staphylococcus aureus
title_sort	predictive role of targeted, active surveillance cultures for detection of methicillin-resistant staphylococcus aureus
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/9f6436db5a084401aece8c998f21a6e8
work_keys_str_mv	AT almusawis predictiveroleoftargetedactivesurveillanceculturesfordetectionofmethicillinresistantstaphylococcusaureus AT alkhaleefaq predictiveroleoftargetedactivesurveillanceculturesfordetectionofmethicillinresistantstaphylococcusaureus AT alnassris predictiveroleoftargetedactivesurveillanceculturesfordetectionofmethicillinresistantstaphylococcusaureus AT alamria predictiveroleoftargetedactivesurveillanceculturesfordetectionofmethicillinresistantstaphylococcusaureus AT alnimra predictiveroleoftargetedactivesurveillanceculturesfordetectionofmethicillinresistantstaphylococcusaureus
_version_	1718429000244658176

Predictive Role of Targeted, Active Surveillance Cultures for Detection of Methicillin-Resistant Staphylococcus aureus

Ejemplares similares