Exploring the prevalence of ten polyomaviruses and two herpes viruses in breast cancer.

Several different viruses have been proposed to play a role in breast carcinogenesis. The aim of this study was to investigate the prevalence of a subset of viruses in breast cancer tissue. We investigated the prevalence of 12 DNA viruses: EBV and CMV from the Herpesviridae family and SV40, BKV, JCV...

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Autores principales:	Annika Antonsson, Seweryn Bialasiewicz, Rebecca J Rockett, Kevin Jacob, Ian C Bennett, Theo P Sloots
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/9f662e2ec8dc4c95900312f1e0bd05e6
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spelling	oai:doaj.org-article:9f662e2ec8dc4c95900312f1e0bd05e62021-11-18T07:08:40ZExploring the prevalence of ten polyomaviruses and two herpes viruses in breast cancer.1932-620310.1371/journal.pone.0039842https://doaj.org/article/9f662e2ec8dc4c95900312f1e0bd05e62012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22916092/?tool=EBIhttps://doaj.org/toc/1932-6203Several different viruses have been proposed to play a role in breast carcinogenesis. The aim of this study was to investigate the prevalence of a subset of viruses in breast cancer tissue. We investigated the prevalence of 12 DNA viruses: EBV and CMV from the Herpesviridae family and SV40, BKV, JCV, MCV, WUV, KIV, LPV, HPyV6, HPyV7, and TSV from the Polyomaviridae family in 54 fresh frozen breast tumour specimens. Relevant clinical data and basic lifestyle data were available for all patients. The tissue samples were DNA extracted and real-time PCR assays were used for viral detection.The highest prevalence, 10% (5/54), was found for EBV. MCV, HPyV6, and HPyV7 were detected in single patient samples (2% each), while WUV, KIV, JCV, BKV, LPV, SV40, TSV and CMV were not detected in the 54 breast cancer specimens analysed here. Further investigations are needed to elucidate the potential role of viruses, and particularly EBV, in breast carcinogenesis.Annika AntonssonSeweryn BialasiewiczRebecca J RockettKevin JacobIan C BennettTheo P SlootsPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 8, p e39842 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Annika Antonsson Seweryn Bialasiewicz Rebecca J Rockett Kevin Jacob Ian C Bennett Theo P Sloots Exploring the prevalence of ten polyomaviruses and two herpes viruses in breast cancer.
description	Several different viruses have been proposed to play a role in breast carcinogenesis. The aim of this study was to investigate the prevalence of a subset of viruses in breast cancer tissue. We investigated the prevalence of 12 DNA viruses: EBV and CMV from the Herpesviridae family and SV40, BKV, JCV, MCV, WUV, KIV, LPV, HPyV6, HPyV7, and TSV from the Polyomaviridae family in 54 fresh frozen breast tumour specimens. Relevant clinical data and basic lifestyle data were available for all patients. The tissue samples were DNA extracted and real-time PCR assays were used for viral detection.The highest prevalence, 10% (5/54), was found for EBV. MCV, HPyV6, and HPyV7 were detected in single patient samples (2% each), while WUV, KIV, JCV, BKV, LPV, SV40, TSV and CMV were not detected in the 54 breast cancer specimens analysed here. Further investigations are needed to elucidate the potential role of viruses, and particularly EBV, in breast carcinogenesis.
format	article
author	Annika Antonsson Seweryn Bialasiewicz Rebecca J Rockett Kevin Jacob Ian C Bennett Theo P Sloots
author_facet	Annika Antonsson Seweryn Bialasiewicz Rebecca J Rockett Kevin Jacob Ian C Bennett Theo P Sloots
author_sort	Annika Antonsson
title	Exploring the prevalence of ten polyomaviruses and two herpes viruses in breast cancer.
title_short	Exploring the prevalence of ten polyomaviruses and two herpes viruses in breast cancer.
title_full	Exploring the prevalence of ten polyomaviruses and two herpes viruses in breast cancer.
title_fullStr	Exploring the prevalence of ten polyomaviruses and two herpes viruses in breast cancer.
title_full_unstemmed	Exploring the prevalence of ten polyomaviruses and two herpes viruses in breast cancer.
title_sort	exploring the prevalence of ten polyomaviruses and two herpes viruses in breast cancer.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/9f662e2ec8dc4c95900312f1e0bd05e6
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Exploring the prevalence of ten polyomaviruses and two herpes viruses in breast cancer.

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