Association of Serum Renalase Levels and Renalase rs10887800 Polymorphism with Unstable Angina Pectoris Patients Having Metabolic Syndrome

Peyman Izadpanah,1 Fatemeh Asadian,2 Ali Jangjou3 1Cardiology Department, Shiraz University of Medical Sciences, Shiraz, Iran; 2Department of Medical Laboratory Sciences, School of Paramedical Sciences, Shiraz University of Medical Sciences, Shiraz, Iran; 3Emergency Medicine Department, Shiraz Unive...

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Autores principales:	Izadpanah P, Asadian F, Jangjou A
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	cardiovascular diseases metabolic syndrome polymorphism renalase rs10887800 unstable angina pectoris Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/9f6668e371de42eabf5bcb8c21f319d1
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spelling	oai:doaj.org-article:9f6668e371de42eabf5bcb8c21f319d12021-12-02T11:23:06ZAssociation of Serum Renalase Levels and Renalase rs10887800 Polymorphism with Unstable Angina Pectoris Patients Having Metabolic Syndrome1178-7007https://doaj.org/article/9f6668e371de42eabf5bcb8c21f319d12020-09-01T00:00:00Zhttps://www.dovepress.com/association-of-serum-renalase-levels-and-renalase-rs10887800-polymorph-peer-reviewed-article-DMSOhttps://doaj.org/toc/1178-7007Peyman Izadpanah,1 Fatemeh Asadian,2 Ali Jangjou3 1Cardiology Department, Shiraz University of Medical Sciences, Shiraz, Iran; 2Department of Medical Laboratory Sciences, School of Paramedical Sciences, Shiraz University of Medical Sciences, Shiraz, Iran; 3Emergency Medicine Department, Shiraz University of Medical Sciences, Shiraz, IranCorrespondence: Ali JangjouEmergency Medicine Department, Shiraz University of Medical Sciences, Shiraz, IranTel +98-9173157555Email ali_jangjou@ymail.comPurpose: An increased risk of cardiovascular mortality and morbidity has been linked with metabolic syndrome (MetS), described as the secondary risk reduction target. These patients are predisposed to high complication levels such as unstable angina-pectoris (USAP) by MetS. As with the role of renalase in the regulation of blood pressure (BP), the study was carried out to determine the levels of renalase circulation in patients with USAP and MetS (USAP+MetS), as well as the association of renalase gene (RNLS) rs10887800 polymorphism and USAP and MetS susceptibility.Patients and Methods: A total of 134 patients with USAP+MetS and 134 control subjects were recruited in this case-control study.Results: Renalase was found to have a significantly higher level in USAP+MetS patients (23.28 ± 4.09 μg/dL) than in healthy ones (20.81 ± 2.73 μg/dL) (P < 0.001). Also, it was shown that renalase sensitivity and specificity values for the early diagnosis of USAP and MetS seemed to be 53.7% and 76.9, respectively. Moreover, the value for renalase area under curve (AUC) was 0.654 (95% CI: 0.58– 0.72). The frequency of rs10887800 AG and GG genotypes of RNLS gene was significantly higher in USAP+MetS patients than in control subjects, suggesting that this genotype might be a risk factor against USAP+MetS (OR = 2.114 [95% CI 1.113– 4.016]; P = 0.022) and (OR = 2.057 [95% CI 1.011– 4.186]; P = 0.047), respectively.Conclusion: The present results showed that renalase serum levels increased in USAP and MetS patients. Moreover, the RNLS rs10887800 was reported to be associated with a higher risk of USAP+MetS.Keywords: cardiovascular diseases, metabolic syndrome, polymorphism, renalase, rs10887800, unstable angina pectorisIzadpanah PAsadian FJangjou ADove Medical Pressarticlecardiovascular diseasesmetabolic syndromepolymorphismrenalasers10887800unstable angina pectorisSpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 13, Pp 3249-3259 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	cardiovascular diseases metabolic syndrome polymorphism renalase rs10887800 unstable angina pectoris Specialties of internal medicine RC581-951
spellingShingle	cardiovascular diseases metabolic syndrome polymorphism renalase rs10887800 unstable angina pectoris Specialties of internal medicine RC581-951 Izadpanah P Asadian F Jangjou A Association of Serum Renalase Levels and Renalase rs10887800 Polymorphism with Unstable Angina Pectoris Patients Having Metabolic Syndrome
description	Peyman Izadpanah,1 Fatemeh Asadian,2 Ali Jangjou3 1Cardiology Department, Shiraz University of Medical Sciences, Shiraz, Iran; 2Department of Medical Laboratory Sciences, School of Paramedical Sciences, Shiraz University of Medical Sciences, Shiraz, Iran; 3Emergency Medicine Department, Shiraz University of Medical Sciences, Shiraz, IranCorrespondence: Ali JangjouEmergency Medicine Department, Shiraz University of Medical Sciences, Shiraz, IranTel +98-9173157555Email ali_jangjou@ymail.comPurpose: An increased risk of cardiovascular mortality and morbidity has been linked with metabolic syndrome (MetS), described as the secondary risk reduction target. These patients are predisposed to high complication levels such as unstable angina-pectoris (USAP) by MetS. As with the role of renalase in the regulation of blood pressure (BP), the study was carried out to determine the levels of renalase circulation in patients with USAP and MetS (USAP+MetS), as well as the association of renalase gene (RNLS) rs10887800 polymorphism and USAP and MetS susceptibility.Patients and Methods: A total of 134 patients with USAP+MetS and 134 control subjects were recruited in this case-control study.Results: Renalase was found to have a significantly higher level in USAP+MetS patients (23.28 ± 4.09 μg/dL) than in healthy ones (20.81 ± 2.73 μg/dL) (P < 0.001). Also, it was shown that renalase sensitivity and specificity values for the early diagnosis of USAP and MetS seemed to be 53.7% and 76.9, respectively. Moreover, the value for renalase area under curve (AUC) was 0.654 (95% CI: 0.58– 0.72). The frequency of rs10887800 AG and GG genotypes of RNLS gene was significantly higher in USAP+MetS patients than in control subjects, suggesting that this genotype might be a risk factor against USAP+MetS (OR = 2.114 [95% CI 1.113– 4.016]; P = 0.022) and (OR = 2.057 [95% CI 1.011– 4.186]; P = 0.047), respectively.Conclusion: The present results showed that renalase serum levels increased in USAP and MetS patients. Moreover, the RNLS rs10887800 was reported to be associated with a higher risk of USAP+MetS.Keywords: cardiovascular diseases, metabolic syndrome, polymorphism, renalase, rs10887800, unstable angina pectoris
format	article
author	Izadpanah P Asadian F Jangjou A
author_facet	Izadpanah P Asadian F Jangjou A
author_sort	Izadpanah P
title	Association of Serum Renalase Levels and Renalase rs10887800 Polymorphism with Unstable Angina Pectoris Patients Having Metabolic Syndrome
title_short	Association of Serum Renalase Levels and Renalase rs10887800 Polymorphism with Unstable Angina Pectoris Patients Having Metabolic Syndrome
title_full	Association of Serum Renalase Levels and Renalase rs10887800 Polymorphism with Unstable Angina Pectoris Patients Having Metabolic Syndrome
title_fullStr	Association of Serum Renalase Levels and Renalase rs10887800 Polymorphism with Unstable Angina Pectoris Patients Having Metabolic Syndrome
title_full_unstemmed	Association of Serum Renalase Levels and Renalase rs10887800 Polymorphism with Unstable Angina Pectoris Patients Having Metabolic Syndrome
title_sort	association of serum renalase levels and renalase rs10887800 polymorphism with unstable angina pectoris patients having metabolic syndrome
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/9f6668e371de42eabf5bcb8c21f319d1
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Association of Serum Renalase Levels and Renalase rs10887800 Polymorphism with Unstable Angina Pectoris Patients Having Metabolic Syndrome

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