Endogenous FGF21-signaling controls paradoxical obesity resistance of UCP1-deficient mice

Brown adipose thermogenesis increases energy expenditure and relies on uncoupling protein 1 (UCP1), however, UCP1 knock-out mice show resistance to diet-induced obesity at room temperature. Here, the authors show that this resistance relies on FGF21-signaling, inducing the browning of white adipose...

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Autores principales:	Susanne Keipert, Dominik Lutter, Bjoern O. Schroeder, Daniel Brandt, Marcus Ståhlman, Thomas Schwarzmayr, Elisabeth Graf, Helmut Fuchs, Martin Hrabe de Angelis, Matthias H. Tschöp, Jan Rozman, Martin Jastroch
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/9f6878bc1fa4458ca06f077b004448cb
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spelling	oai:doaj.org-article:9f6878bc1fa4458ca06f077b004448cb2021-12-02T14:42:29ZEndogenous FGF21-signaling controls paradoxical obesity resistance of UCP1-deficient mice10.1038/s41467-019-14069-22041-1723https://doaj.org/article/9f6878bc1fa4458ca06f077b004448cb2020-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-14069-2https://doaj.org/toc/2041-1723Brown adipose thermogenesis increases energy expenditure and relies on uncoupling protein 1 (UCP1), however, UCP1 knock-out mice show resistance to diet-induced obesity at room temperature. Here, the authors show that this resistance relies on FGF21-signaling, inducing the browning of white adipose tissue.Susanne KeipertDominik LutterBjoern O. SchroederDaniel BrandtMarcus StåhlmanThomas SchwarzmayrElisabeth GrafHelmut FuchsMartin Hrabe de AngelisMatthias H. TschöpJan RozmanMartin JastrochNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Susanne Keipert Dominik Lutter Bjoern O. Schroeder Daniel Brandt Marcus Ståhlman Thomas Schwarzmayr Elisabeth Graf Helmut Fuchs Martin Hrabe de Angelis Matthias H. Tschöp Jan Rozman Martin Jastroch Endogenous FGF21-signaling controls paradoxical obesity resistance of UCP1-deficient mice
description	Brown adipose thermogenesis increases energy expenditure and relies on uncoupling protein 1 (UCP1), however, UCP1 knock-out mice show resistance to diet-induced obesity at room temperature. Here, the authors show that this resistance relies on FGF21-signaling, inducing the browning of white adipose tissue.
format	article
author	Susanne Keipert Dominik Lutter Bjoern O. Schroeder Daniel Brandt Marcus Ståhlman Thomas Schwarzmayr Elisabeth Graf Helmut Fuchs Martin Hrabe de Angelis Matthias H. Tschöp Jan Rozman Martin Jastroch
author_facet	Susanne Keipert Dominik Lutter Bjoern O. Schroeder Daniel Brandt Marcus Ståhlman Thomas Schwarzmayr Elisabeth Graf Helmut Fuchs Martin Hrabe de Angelis Matthias H. Tschöp Jan Rozman Martin Jastroch
author_sort	Susanne Keipert
title	Endogenous FGF21-signaling controls paradoxical obesity resistance of UCP1-deficient mice
title_short	Endogenous FGF21-signaling controls paradoxical obesity resistance of UCP1-deficient mice
title_full	Endogenous FGF21-signaling controls paradoxical obesity resistance of UCP1-deficient mice
title_fullStr	Endogenous FGF21-signaling controls paradoxical obesity resistance of UCP1-deficient mice
title_full_unstemmed	Endogenous FGF21-signaling controls paradoxical obesity resistance of UCP1-deficient mice
title_sort	endogenous fgf21-signaling controls paradoxical obesity resistance of ucp1-deficient mice
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/9f6878bc1fa4458ca06f077b004448cb
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Endogenous FGF21-signaling controls paradoxical obesity resistance of UCP1-deficient mice

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