Evaluation of Vascular Endothelial Function in Children with Type 1 Diabetes Mellitus

Diabetic kidney disease belongs to the major complications of diabetes mellitus. Here, hyperglycaemia is a key metabolic factor that causes endothelial dysfunction and vascular changes within the renal glomerulus. The aim of the present study was to assess the function of the vascular endothelium in...

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Autores principales:	Karolina Nocuń-Wasilewska, Danuta Zwolińska, Agnieszka Zubkiewicz-Kucharska, Dorota Polak-Jonkisz
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	diabetic kidney disease vascular endothelial markers children eGFR Medicine R
Acceso en línea:	https://doaj.org/article/9f6f88877e844cacaca771f9f99f3338
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spelling	oai:doaj.org-article:9f6f88877e844cacaca771f9f99f33382021-11-11T17:41:34ZEvaluation of Vascular Endothelial Function in Children with Type 1 Diabetes Mellitus10.3390/jcm102150652077-0383https://doaj.org/article/9f6f88877e844cacaca771f9f99f33382021-10-01T00:00:00Zhttps://www.mdpi.com/2077-0383/10/21/5065https://doaj.org/toc/2077-0383Diabetic kidney disease belongs to the major complications of diabetes mellitus. Here, hyperglycaemia is a key metabolic factor that causes endothelial dysfunction and vascular changes within the renal glomerulus. The aim of the present study was to assess the function of the vascular endothelium in children with type 1 diabetes mellitus (type 1 diabetes) by measuring selected endothelial lesion markers in blood serum. The selected markers of endothelial lesions (sVCAM-1, sICAM-1, sE-SELECTIN, PAI-1, ADMA and RAGE) were assayed by the immunoenzymatic ELISA method. The study involved 66 patients (age: 5–18 years) with type 1 diabetes and 21 healthy controls (age: 5–16 years). In the type 1 diabetes patients, significantly higher concentrations of all of the assayed markers were observed compared to the healthy controls (<i>p</i> < 0.001). All of the evaluated markers positively correlated with the disease duration, the age, and BMI of the patients, while only PAI-1 and sE-SELECTIN were characteristic of linear correlations with the estimated glomerular filtration rate (eGFR). It can be concluded that endothelial inflammatory disease occurs in the early stages of type 1 diabetes mellitus in children. The correlations between PAI-1, sE-SELECTIN, and eGFR suggest an advantage of these markers over other markers of endothelial dysfunction as prognostic factors for kidney dysfunction in children with type 1 diabetes.Karolina Nocuń-WasilewskaDanuta ZwolińskaAgnieszka Zubkiewicz-KucharskaDorota Polak-JonkiszMDPI AGarticlediabetic kidney diseasevascular endothelial markerschildreneGFRMedicineRENJournal of Clinical Medicine, Vol 10, Iss 5065, p 5065 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	diabetic kidney disease vascular endothelial markers children eGFR Medicine R
spellingShingle	diabetic kidney disease vascular endothelial markers children eGFR Medicine R Karolina Nocuń-Wasilewska Danuta Zwolińska Agnieszka Zubkiewicz-Kucharska Dorota Polak-Jonkisz Evaluation of Vascular Endothelial Function in Children with Type 1 Diabetes Mellitus
description	Diabetic kidney disease belongs to the major complications of diabetes mellitus. Here, hyperglycaemia is a key metabolic factor that causes endothelial dysfunction and vascular changes within the renal glomerulus. The aim of the present study was to assess the function of the vascular endothelium in children with type 1 diabetes mellitus (type 1 diabetes) by measuring selected endothelial lesion markers in blood serum. The selected markers of endothelial lesions (sVCAM-1, sICAM-1, sE-SELECTIN, PAI-1, ADMA and RAGE) were assayed by the immunoenzymatic ELISA method. The study involved 66 patients (age: 5–18 years) with type 1 diabetes and 21 healthy controls (age: 5–16 years). In the type 1 diabetes patients, significantly higher concentrations of all of the assayed markers were observed compared to the healthy controls (<i>p</i> < 0.001). All of the evaluated markers positively correlated with the disease duration, the age, and BMI of the patients, while only PAI-1 and sE-SELECTIN were characteristic of linear correlations with the estimated glomerular filtration rate (eGFR). It can be concluded that endothelial inflammatory disease occurs in the early stages of type 1 diabetes mellitus in children. The correlations between PAI-1, sE-SELECTIN, and eGFR suggest an advantage of these markers over other markers of endothelial dysfunction as prognostic factors for kidney dysfunction in children with type 1 diabetes.
format	article
author	Karolina Nocuń-Wasilewska Danuta Zwolińska Agnieszka Zubkiewicz-Kucharska Dorota Polak-Jonkisz
author_facet	Karolina Nocuń-Wasilewska Danuta Zwolińska Agnieszka Zubkiewicz-Kucharska Dorota Polak-Jonkisz
author_sort	Karolina Nocuń-Wasilewska
title	Evaluation of Vascular Endothelial Function in Children with Type 1 Diabetes Mellitus
title_short	Evaluation of Vascular Endothelial Function in Children with Type 1 Diabetes Mellitus
title_full	Evaluation of Vascular Endothelial Function in Children with Type 1 Diabetes Mellitus
title_fullStr	Evaluation of Vascular Endothelial Function in Children with Type 1 Diabetes Mellitus
title_full_unstemmed	Evaluation of Vascular Endothelial Function in Children with Type 1 Diabetes Mellitus
title_sort	evaluation of vascular endothelial function in children with type 1 diabetes mellitus
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/9f6f88877e844cacaca771f9f99f3338
work_keys_str_mv	AT karolinanocunwasilewska evaluationofvascularendothelialfunctioninchildrenwithtype1diabetesmellitus AT danutazwolinska evaluationofvascularendothelialfunctioninchildrenwithtype1diabetesmellitus AT agnieszkazubkiewiczkucharska evaluationofvascularendothelialfunctioninchildrenwithtype1diabetesmellitus AT dorotapolakjonkisz evaluationofvascularendothelialfunctioninchildrenwithtype1diabetesmellitus
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Evaluation of Vascular Endothelial Function in Children with Type 1 Diabetes Mellitus

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