Effect of orotic acid addition on hydrolysis conversion of α‐tricalcium phosphate to hydroxyapatite

Abstract Alpha‐tricalcium phosphate (α‐TCP), which can be converted to calcium‐deficient hydroxyapatite (HA) by hydrolysis reaction, has been researched as a bone filling. Although the composites of α‐TCP with various organic molecules can exhibit a novel functionality, the reaction based on the add...

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Autores principales:	Iori Yamada, Tania Guadalupe Peñaflor Galindo, Daichi Noda, Motohiro Tagaya
Formato:	article
Lenguaje:	EN
Publicado:	Wiley 2021
Materias:	bioceramics calcium phosphate orotic acid biomineralization Clay industries. Ceramics. Glass TP785-869
Acceso en línea:	https://doaj.org/article/9f71bcbca82e4d95a95cd9e5527ea518
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spelling	oai:doaj.org-article:9f71bcbca82e4d95a95cd9e5527ea5182021-11-16T17:11:08ZEffect of orotic acid addition on hydrolysis conversion of α‐tricalcium phosphate to hydroxyapatite2578-327010.1002/ces2.10109https://doaj.org/article/9f71bcbca82e4d95a95cd9e5527ea5182021-11-01T00:00:00Zhttps://doi.org/10.1002/ces2.10109https://doaj.org/toc/2578-3270Abstract Alpha‐tricalcium phosphate (α‐TCP), which can be converted to calcium‐deficient hydroxyapatite (HA) by hydrolysis reaction, has been researched as a bone filling. Although the composites of α‐TCP with various organic molecules can exhibit a novel functionality, the reaction based on the addition of the interactive organic molecules has not been understood. Investigation of the hydrolysis conversion process under various conditions can lead to the elucidation of the biomineralization process. In this study, we investigated the hydrolysis conversion of α‐TCP to HA in the presence of orotic acid (Ort). As a result, the conversion rate from α‐TCP to HA at the reaction time of 3 h was improved to be more than five times as compared to that in the absence of Ort. Moreover, the addition of Ort promoted the crystal growth and suppressed the crystal growth in the m‐plane direction. Furthermore, the mechanism for promoting HA formation is assumed to be related to the molecular structure of Ort, which is capable of forming the interactions between carboxylate and Ca2+ ions.Iori YamadaTania Guadalupe Peñaflor GalindoDaichi NodaMotohiro TagayaWileyarticlebioceramicscalcium phosphateorotic acidbiomineralizationClay industries. Ceramics. GlassTP785-869ENInternational Journal of Ceramic Engineering & Science, Vol 3, Iss 6, Pp 267-271 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	bioceramics calcium phosphate orotic acid biomineralization Clay industries. Ceramics. Glass TP785-869
spellingShingle	bioceramics calcium phosphate orotic acid biomineralization Clay industries. Ceramics. Glass TP785-869 Iori Yamada Tania Guadalupe Peñaflor Galindo Daichi Noda Motohiro Tagaya Effect of orotic acid addition on hydrolysis conversion of α‐tricalcium phosphate to hydroxyapatite
description	Abstract Alpha‐tricalcium phosphate (α‐TCP), which can be converted to calcium‐deficient hydroxyapatite (HA) by hydrolysis reaction, has been researched as a bone filling. Although the composites of α‐TCP with various organic molecules can exhibit a novel functionality, the reaction based on the addition of the interactive organic molecules has not been understood. Investigation of the hydrolysis conversion process under various conditions can lead to the elucidation of the biomineralization process. In this study, we investigated the hydrolysis conversion of α‐TCP to HA in the presence of orotic acid (Ort). As a result, the conversion rate from α‐TCP to HA at the reaction time of 3 h was improved to be more than five times as compared to that in the absence of Ort. Moreover, the addition of Ort promoted the crystal growth and suppressed the crystal growth in the m‐plane direction. Furthermore, the mechanism for promoting HA formation is assumed to be related to the molecular structure of Ort, which is capable of forming the interactions between carboxylate and Ca2+ ions.
format	article
author	Iori Yamada Tania Guadalupe Peñaflor Galindo Daichi Noda Motohiro Tagaya
author_facet	Iori Yamada Tania Guadalupe Peñaflor Galindo Daichi Noda Motohiro Tagaya
author_sort	Iori Yamada
title	Effect of orotic acid addition on hydrolysis conversion of α‐tricalcium phosphate to hydroxyapatite
title_short	Effect of orotic acid addition on hydrolysis conversion of α‐tricalcium phosphate to hydroxyapatite
title_full	Effect of orotic acid addition on hydrolysis conversion of α‐tricalcium phosphate to hydroxyapatite
title_fullStr	Effect of orotic acid addition on hydrolysis conversion of α‐tricalcium phosphate to hydroxyapatite
title_full_unstemmed	Effect of orotic acid addition on hydrolysis conversion of α‐tricalcium phosphate to hydroxyapatite
title_sort	effect of orotic acid addition on hydrolysis conversion of α‐tricalcium phosphate to hydroxyapatite
publisher	Wiley
publishDate	2021
url	https://doaj.org/article/9f71bcbca82e4d95a95cd9e5527ea518
work_keys_str_mv	AT ioriyamada effectoforoticacidadditiononhydrolysisconversionofatricalciumphosphatetohydroxyapatite AT taniaguadalupepenaflorgalindo effectoforoticacidadditiononhydrolysisconversionofatricalciumphosphatetohydroxyapatite AT daichinoda effectoforoticacidadditiononhydrolysisconversionofatricalciumphosphatetohydroxyapatite AT motohirotagaya effectoforoticacidadditiononhydrolysisconversionofatricalciumphosphatetohydroxyapatite
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Effect of orotic acid addition on hydrolysis conversion of α‐tricalcium phosphate to hydroxyapatite

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