A phenotypic structure and neural correlates of compulsive behaviors in adolescents.
<h4>Background</h4>A compulsivity spectrum has been hypothesized to exist across Obsessive-Compulsive disorder (OCD), Eating Disorders (ED), substance abuse (SA) and binge-drinking (BD). The objective was to examine the validity of this compulsivity spectrum, and differentiate it from an...
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2013
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oai:doaj.org-article:9f72e1302c0d4a349e28fec7dafeab112021-11-18T08:46:26ZA phenotypic structure and neural correlates of compulsive behaviors in adolescents.1932-620310.1371/journal.pone.0080151https://doaj.org/article/9f72e1302c0d4a349e28fec7dafeab112013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24244633/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>A compulsivity spectrum has been hypothesized to exist across Obsessive-Compulsive disorder (OCD), Eating Disorders (ED), substance abuse (SA) and binge-drinking (BD). The objective was to examine the validity of this compulsivity spectrum, and differentiate it from an externalizing behaviors dimension, but also to look at hypothesized personality and neural correlates.<h4>Method</h4>A community-sample of adolescents (N=1938; mean age 14.5 years), and their parents were recruited via high-schools in 8 European study sites. Data on adolescents' psychiatric symptoms, DSM diagnoses (DAWBA) and substance use behaviors (AUDIT and ESPAD) were collected through adolescent- and parent-reported questionnaires and interviews. The phenotypic structure of compulsive behaviors was then tested using structural equation modeling. The model was validated using personality variables (NEO-FFI and TCI), and Voxel-Based Morphometry (VBM) analysis.<h4>Results</h4>Compulsivity symptoms best fit a higher-order two factor model, with ED and OCD loading onto a compulsivity factor, and BD and SA loading onto an externalizing factor, composed also of ADHD and conduct disorder symptoms. The compulsivity construct correlated with neuroticism (r=0.638; p ≤ 0.001), conscientiousness (r=0.171; p ≤ 0.001), and brain gray matter volume in left and right orbitofrontal cortex, right ventral striatum and right dorsolateral prefrontal cortex. The externalizing factor correlated with extraversion (r=0.201; p ≤ 0.001), novelty-seeking (r=0.451; p ≤ 0.001), and negatively with gray matter volume in the left inferior and middle frontal gyri.<h4>Conclusions</h4>Results suggest that a compulsivity spectrum exists in an adolescent, preclinical sample and accounts for variance in both OCD and ED, but not substance-related behaviors, and can be differentiated from an externalizing spectrum.Chantale MontignyNatalie Castellanos-RyanRobert WhelanTobias BanaschewskiGareth J BarkerChristian BüchelJürgen GallinatHerta FlorKarl MannMarie-Laure Paillère-MartinotFrauke NeesMark LathropEva LothTomas PausZdenka PausovaMarcella RietschelGunter SchumannMichael N SmolkaMaren StruveTrevor W RobbinsHugh GaravanPatricia J ConrodIMAGEN ConsortiumPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 11, p e80151 (2013) |
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Medicine R Science Q |
| spellingShingle |
Medicine R Science Q Chantale Montigny Natalie Castellanos-Ryan Robert Whelan Tobias Banaschewski Gareth J Barker Christian Büchel Jürgen Gallinat Herta Flor Karl Mann Marie-Laure Paillère-Martinot Frauke Nees Mark Lathrop Eva Loth Tomas Paus Zdenka Pausova Marcella Rietschel Gunter Schumann Michael N Smolka Maren Struve Trevor W Robbins Hugh Garavan Patricia J Conrod IMAGEN Consortium A phenotypic structure and neural correlates of compulsive behaviors in adolescents. |
| description |
<h4>Background</h4>A compulsivity spectrum has been hypothesized to exist across Obsessive-Compulsive disorder (OCD), Eating Disorders (ED), substance abuse (SA) and binge-drinking (BD). The objective was to examine the validity of this compulsivity spectrum, and differentiate it from an externalizing behaviors dimension, but also to look at hypothesized personality and neural correlates.<h4>Method</h4>A community-sample of adolescents (N=1938; mean age 14.5 years), and their parents were recruited via high-schools in 8 European study sites. Data on adolescents' psychiatric symptoms, DSM diagnoses (DAWBA) and substance use behaviors (AUDIT and ESPAD) were collected through adolescent- and parent-reported questionnaires and interviews. The phenotypic structure of compulsive behaviors was then tested using structural equation modeling. The model was validated using personality variables (NEO-FFI and TCI), and Voxel-Based Morphometry (VBM) analysis.<h4>Results</h4>Compulsivity symptoms best fit a higher-order two factor model, with ED and OCD loading onto a compulsivity factor, and BD and SA loading onto an externalizing factor, composed also of ADHD and conduct disorder symptoms. The compulsivity construct correlated with neuroticism (r=0.638; p ≤ 0.001), conscientiousness (r=0.171; p ≤ 0.001), and brain gray matter volume in left and right orbitofrontal cortex, right ventral striatum and right dorsolateral prefrontal cortex. The externalizing factor correlated with extraversion (r=0.201; p ≤ 0.001), novelty-seeking (r=0.451; p ≤ 0.001), and negatively with gray matter volume in the left inferior and middle frontal gyri.<h4>Conclusions</h4>Results suggest that a compulsivity spectrum exists in an adolescent, preclinical sample and accounts for variance in both OCD and ED, but not substance-related behaviors, and can be differentiated from an externalizing spectrum. |
| format |
article |
| author |
Chantale Montigny Natalie Castellanos-Ryan Robert Whelan Tobias Banaschewski Gareth J Barker Christian Büchel Jürgen Gallinat Herta Flor Karl Mann Marie-Laure Paillère-Martinot Frauke Nees Mark Lathrop Eva Loth Tomas Paus Zdenka Pausova Marcella Rietschel Gunter Schumann Michael N Smolka Maren Struve Trevor W Robbins Hugh Garavan Patricia J Conrod IMAGEN Consortium |
| author_facet |
Chantale Montigny Natalie Castellanos-Ryan Robert Whelan Tobias Banaschewski Gareth J Barker Christian Büchel Jürgen Gallinat Herta Flor Karl Mann Marie-Laure Paillère-Martinot Frauke Nees Mark Lathrop Eva Loth Tomas Paus Zdenka Pausova Marcella Rietschel Gunter Schumann Michael N Smolka Maren Struve Trevor W Robbins Hugh Garavan Patricia J Conrod IMAGEN Consortium |
| author_sort |
Chantale Montigny |
| title |
A phenotypic structure and neural correlates of compulsive behaviors in adolescents. |
| title_short |
A phenotypic structure and neural correlates of compulsive behaviors in adolescents. |
| title_full |
A phenotypic structure and neural correlates of compulsive behaviors in adolescents. |
| title_fullStr |
A phenotypic structure and neural correlates of compulsive behaviors in adolescents. |
| title_full_unstemmed |
A phenotypic structure and neural correlates of compulsive behaviors in adolescents. |
| title_sort |
phenotypic structure and neural correlates of compulsive behaviors in adolescents. |
| publisher |
Public Library of Science (PLoS) |
| publishDate |
2013 |
| url |
https://doaj.org/article/9f72e1302c0d4a349e28fec7dafeab11 |
| work_keys_str_mv |
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