DNA damage-induced PARP1 activation confers cardiomyocyte dysfunction through NAD+ depletion in experimental atrial fibrillation

Atrial fibrillation (AF) is accompanied by a detrimental loss of functional cardiomyocytes. Here, Zhang et al. show that AF-induced cardiomyocyte dysfunction is a consequence of DNA damage-mediated PARP1 activation, which leads to depletion of NAD+ and further oxidative stress and DNA damage, and id...

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Autores principales:	Deli Zhang, Xu Hu, Jin Li, Jia Liu, Luciënne Baks-te Bulte, Marit Wiersma, Noor-ul-Ann Malik, Denise M. S. van Marion, Marziyeh Tolouee, Femke Hoogstra-Berends, Eva A. H. Lanters, Arie M. van Roon, Antoine A. F. de Vries, Daniël A. Pijnappels, Natasja M. S. de Groot, Robert H. Henning, Bianca J. J. M. Brundel
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/9f755550b82b4522aecca3e20910e91e
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spelling	oai:doaj.org-article:9f755550b82b4522aecca3e20910e91e2021-12-02T17:01:32ZDNA damage-induced PARP1 activation confers cardiomyocyte dysfunction through NAD+ depletion in experimental atrial fibrillation10.1038/s41467-019-09014-22041-1723https://doaj.org/article/9f755550b82b4522aecca3e20910e91e2019-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09014-2https://doaj.org/toc/2041-1723Atrial fibrillation (AF) is accompanied by a detrimental loss of functional cardiomyocytes. Here, Zhang et al. show that AF-induced cardiomyocyte dysfunction is a consequence of DNA damage-mediated PARP1 activation, which leads to depletion of NAD+ and further oxidative stress and DNA damage, and identify PARP1 inhibition as a potential therapeutic strategy in the treatment of AF.Deli ZhangXu HuJin LiJia LiuLuciënne Baks-te BulteMarit WiersmaNoor-ul-Ann MalikDenise M. S. van MarionMarziyeh ToloueeFemke Hoogstra-BerendsEva A. H. LantersArie M. van RoonAntoine A. F. de VriesDaniël A. PijnappelsNatasja M. S. de GrootRobert H. HenningBianca J. J. M. BrundelNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Deli Zhang Xu Hu Jin Li Jia Liu Luciënne Baks-te Bulte Marit Wiersma Noor-ul-Ann Malik Denise M. S. van Marion Marziyeh Tolouee Femke Hoogstra-Berends Eva A. H. Lanters Arie M. van Roon Antoine A. F. de Vries Daniël A. Pijnappels Natasja M. S. de Groot Robert H. Henning Bianca J. J. M. Brundel DNA damage-induced PARP1 activation confers cardiomyocyte dysfunction through NAD+ depletion in experimental atrial fibrillation
description	Atrial fibrillation (AF) is accompanied by a detrimental loss of functional cardiomyocytes. Here, Zhang et al. show that AF-induced cardiomyocyte dysfunction is a consequence of DNA damage-mediated PARP1 activation, which leads to depletion of NAD+ and further oxidative stress and DNA damage, and identify PARP1 inhibition as a potential therapeutic strategy in the treatment of AF.
format	article
author	Deli Zhang Xu Hu Jin Li Jia Liu Luciënne Baks-te Bulte Marit Wiersma Noor-ul-Ann Malik Denise M. S. van Marion Marziyeh Tolouee Femke Hoogstra-Berends Eva A. H. Lanters Arie M. van Roon Antoine A. F. de Vries Daniël A. Pijnappels Natasja M. S. de Groot Robert H. Henning Bianca J. J. M. Brundel
author_facet	Deli Zhang Xu Hu Jin Li Jia Liu Luciënne Baks-te Bulte Marit Wiersma Noor-ul-Ann Malik Denise M. S. van Marion Marziyeh Tolouee Femke Hoogstra-Berends Eva A. H. Lanters Arie M. van Roon Antoine A. F. de Vries Daniël A. Pijnappels Natasja M. S. de Groot Robert H. Henning Bianca J. J. M. Brundel
author_sort	Deli Zhang
title	DNA damage-induced PARP1 activation confers cardiomyocyte dysfunction through NAD+ depletion in experimental atrial fibrillation
title_short	DNA damage-induced PARP1 activation confers cardiomyocyte dysfunction through NAD+ depletion in experimental atrial fibrillation
title_full	DNA damage-induced PARP1 activation confers cardiomyocyte dysfunction through NAD+ depletion in experimental atrial fibrillation
title_fullStr	DNA damage-induced PARP1 activation confers cardiomyocyte dysfunction through NAD+ depletion in experimental atrial fibrillation
title_full_unstemmed	DNA damage-induced PARP1 activation confers cardiomyocyte dysfunction through NAD+ depletion in experimental atrial fibrillation
title_sort	dna damage-induced parp1 activation confers cardiomyocyte dysfunction through nad+ depletion in experimental atrial fibrillation
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/9f755550b82b4522aecca3e20910e91e
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DNA damage-induced PARP1 activation confers cardiomyocyte dysfunction through NAD+ depletion in experimental atrial fibrillation

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