DNA damage-induced PARP1 activation confers cardiomyocyte dysfunction through NAD+ depletion in experimental atrial fibrillation

DNA damage-induced PARP1 activation confers cardiomyocyte dysfunction through NAD+ depletion in experimental atrial fibrillation

Atrial fibrillation (AF) is accompanied by a detrimental loss of functional cardiomyocytes. Here, Zhang et al. show that AF-induced cardiomyocyte dysfunction is a consequence of DNA damage-mediated PARP1 activation, which leads to depletion of NAD+ and further oxidative stress and DNA damage, and id...

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Autores principales: Deli Zhang, Xu Hu, Jin Li, Jia Liu, Luciënne Baks-te Bulte, Marit Wiersma, Noor-ul-Ann Malik, Denise M. S. van Marion, Marziyeh Tolouee, Femke Hoogstra-Berends, Eva A. H. Lanters, Arie M. van Roon, Antoine A. F. de Vries, Daniël A. Pijnappels, Natasja M. S. de Groot, Robert H. Henning, Bianca J. J. M. Brundel
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Science
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Acceso en línea:https://doaj.org/article/9f755550b82b4522aecca3e20910e91e
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