Structure-function analysis of purified proanthocyanidins reveals a role for polymer size in suppressing inflammatory responses

Andersen-Civil et al isolated a range of proanthocyanidin (PAC) polymer mixtures from plant material and demonstrated that polymer size was a key determinant of the ability of PACs to regulate inflammatory responses in murine macrophages, and intestinal tissues following oral intake. The PAC polymer...

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Autores principales:	Audrey Inge Schytz Andersen-Civil, Milla Marleena Leppä, Stig M. Thamsborg, Juha-Pekka Salminen, Andrew R. Williams
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/9f7678958b34441e839b880a3cb7d8c6
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spelling	oai:doaj.org-article:9f7678958b34441e839b880a3cb7d8c62021-12-02T16:26:20ZStructure-function analysis of purified proanthocyanidins reveals a role for polymer size in suppressing inflammatory responses10.1038/s42003-021-02408-32399-3642https://doaj.org/article/9f7678958b34441e839b880a3cb7d8c62021-07-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02408-3https://doaj.org/toc/2399-3642Andersen-Civil et al isolated a range of proanthocyanidin (PAC) polymer mixtures from plant material and demonstrated that polymer size was a key determinant of the ability of PACs to regulate inflammatory responses in murine macrophages, and intestinal tissues following oral intake. The PAC polymers modulated autophagic flux and inhibited lipopolysaccharide-induced autophagy in macrophages, which could help to explain the health benefits of PAC-rich food.Audrey Inge Schytz Andersen-CivilMilla Marleena LeppäStig M. ThamsborgJuha-Pekka SalminenAndrew R. WilliamsNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Audrey Inge Schytz Andersen-Civil Milla Marleena Leppä Stig M. Thamsborg Juha-Pekka Salminen Andrew R. Williams Structure-function analysis of purified proanthocyanidins reveals a role for polymer size in suppressing inflammatory responses
description	Andersen-Civil et al isolated a range of proanthocyanidin (PAC) polymer mixtures from plant material and demonstrated that polymer size was a key determinant of the ability of PACs to regulate inflammatory responses in murine macrophages, and intestinal tissues following oral intake. The PAC polymers modulated autophagic flux and inhibited lipopolysaccharide-induced autophagy in macrophages, which could help to explain the health benefits of PAC-rich food.
format	article
author	Audrey Inge Schytz Andersen-Civil Milla Marleena Leppä Stig M. Thamsborg Juha-Pekka Salminen Andrew R. Williams
author_facet	Audrey Inge Schytz Andersen-Civil Milla Marleena Leppä Stig M. Thamsborg Juha-Pekka Salminen Andrew R. Williams
author_sort	Audrey Inge Schytz Andersen-Civil
title	Structure-function analysis of purified proanthocyanidins reveals a role for polymer size in suppressing inflammatory responses
title_short	Structure-function analysis of purified proanthocyanidins reveals a role for polymer size in suppressing inflammatory responses
title_full	Structure-function analysis of purified proanthocyanidins reveals a role for polymer size in suppressing inflammatory responses
title_fullStr	Structure-function analysis of purified proanthocyanidins reveals a role for polymer size in suppressing inflammatory responses
title_full_unstemmed	Structure-function analysis of purified proanthocyanidins reveals a role for polymer size in suppressing inflammatory responses
title_sort	structure-function analysis of purified proanthocyanidins reveals a role for polymer size in suppressing inflammatory responses
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/9f7678958b34441e839b880a3cb7d8c6
work_keys_str_mv	AT audreyingeschytzandersencivil structurefunctionanalysisofpurifiedproanthocyanidinsrevealsaroleforpolymersizeinsuppressinginflammatoryresponses AT millamarleenaleppa structurefunctionanalysisofpurifiedproanthocyanidinsrevealsaroleforpolymersizeinsuppressinginflammatoryresponses AT stigmthamsborg structurefunctionanalysisofpurifiedproanthocyanidinsrevealsaroleforpolymersizeinsuppressinginflammatoryresponses AT juhapekkasalminen structurefunctionanalysisofpurifiedproanthocyanidinsrevealsaroleforpolymersizeinsuppressinginflammatoryresponses AT andrewrwilliams structurefunctionanalysisofpurifiedproanthocyanidinsrevealsaroleforpolymersizeinsuppressinginflammatoryresponses
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Structure-function analysis of purified proanthocyanidins reveals a role for polymer size in suppressing inflammatory responses

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