The epigenetic pioneer EGR2 initiates DNA demethylation in differentiating monocytes at both stable and transient binding sites

DNA methylation turnover is an essential epigenetic process during development. Here, the authors look at the changes in DNA methylation during the differentiation of post-mitotic human monocytes (MO), and find that EGR2 interacts with TET2 and is required for DNA demethylation at its binding sites;...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Karina Mendes, Sandra Schmidhofer, Julia Minderjahn, Dagmar Glatz, Claudia Kiesewetter, Johanna Raithel, Julia Wimmer, Claudia Gebhard, Michael Rehli
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/9f76e08c38bc4cedbd1f8e393116b9f3
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:9f76e08c38bc4cedbd1f8e393116b9f3
record_format	dspace
spelling	oai:doaj.org-article:9f76e08c38bc4cedbd1f8e393116b9f32021-12-02T13:14:59ZThe epigenetic pioneer EGR2 initiates DNA demethylation in differentiating monocytes at both stable and transient binding sites10.1038/s41467-021-21661-y2041-1723https://doaj.org/article/9f76e08c38bc4cedbd1f8e393116b9f32021-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21661-yhttps://doaj.org/toc/2041-1723DNA methylation turnover is an essential epigenetic process during development. Here, the authors look at the changes in DNA methylation during the differentiation of post-mitotic human monocytes (MO), and find that EGR2 interacts with TET2 and is required for DNA demethylation at its binding sites; revealing EGR2 as an epigenetic pioneer factor in human MO.Karina MendesSandra SchmidhoferJulia MinderjahnDagmar GlatzClaudia KiesewetterJohanna RaithelJulia WimmerClaudia GebhardMichael RehliNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Karina Mendes Sandra Schmidhofer Julia Minderjahn Dagmar Glatz Claudia Kiesewetter Johanna Raithel Julia Wimmer Claudia Gebhard Michael Rehli The epigenetic pioneer EGR2 initiates DNA demethylation in differentiating monocytes at both stable and transient binding sites
description	DNA methylation turnover is an essential epigenetic process during development. Here, the authors look at the changes in DNA methylation during the differentiation of post-mitotic human monocytes (MO), and find that EGR2 interacts with TET2 and is required for DNA demethylation at its binding sites; revealing EGR2 as an epigenetic pioneer factor in human MO.
format	article
author	Karina Mendes Sandra Schmidhofer Julia Minderjahn Dagmar Glatz Claudia Kiesewetter Johanna Raithel Julia Wimmer Claudia Gebhard Michael Rehli
author_facet	Karina Mendes Sandra Schmidhofer Julia Minderjahn Dagmar Glatz Claudia Kiesewetter Johanna Raithel Julia Wimmer Claudia Gebhard Michael Rehli
author_sort	Karina Mendes
title	The epigenetic pioneer EGR2 initiates DNA demethylation in differentiating monocytes at both stable and transient binding sites
title_short	The epigenetic pioneer EGR2 initiates DNA demethylation in differentiating monocytes at both stable and transient binding sites
title_full	The epigenetic pioneer EGR2 initiates DNA demethylation in differentiating monocytes at both stable and transient binding sites
title_fullStr	The epigenetic pioneer EGR2 initiates DNA demethylation in differentiating monocytes at both stable and transient binding sites
title_full_unstemmed	The epigenetic pioneer EGR2 initiates DNA demethylation in differentiating monocytes at both stable and transient binding sites
title_sort	epigenetic pioneer egr2 initiates dna demethylation in differentiating monocytes at both stable and transient binding sites
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/9f76e08c38bc4cedbd1f8e393116b9f3
work_keys_str_mv	AT karinamendes theepigeneticpioneeregr2initiatesdnademethylationindifferentiatingmonocytesatbothstableandtransientbindingsites AT sandraschmidhofer theepigeneticpioneeregr2initiatesdnademethylationindifferentiatingmonocytesatbothstableandtransientbindingsites AT juliaminderjahn theepigeneticpioneeregr2initiatesdnademethylationindifferentiatingmonocytesatbothstableandtransientbindingsites AT dagmarglatz theepigeneticpioneeregr2initiatesdnademethylationindifferentiatingmonocytesatbothstableandtransientbindingsites AT claudiakiesewetter theepigeneticpioneeregr2initiatesdnademethylationindifferentiatingmonocytesatbothstableandtransientbindingsites AT johannaraithel theepigeneticpioneeregr2initiatesdnademethylationindifferentiatingmonocytesatbothstableandtransientbindingsites AT juliawimmer theepigeneticpioneeregr2initiatesdnademethylationindifferentiatingmonocytesatbothstableandtransientbindingsites AT claudiagebhard theepigeneticpioneeregr2initiatesdnademethylationindifferentiatingmonocytesatbothstableandtransientbindingsites AT michaelrehli theepigeneticpioneeregr2initiatesdnademethylationindifferentiatingmonocytesatbothstableandtransientbindingsites AT karinamendes epigeneticpioneeregr2initiatesdnademethylationindifferentiatingmonocytesatbothstableandtransientbindingsites AT sandraschmidhofer epigeneticpioneeregr2initiatesdnademethylationindifferentiatingmonocytesatbothstableandtransientbindingsites AT juliaminderjahn epigeneticpioneeregr2initiatesdnademethylationindifferentiatingmonocytesatbothstableandtransientbindingsites AT dagmarglatz epigeneticpioneeregr2initiatesdnademethylationindifferentiatingmonocytesatbothstableandtransientbindingsites AT claudiakiesewetter epigeneticpioneeregr2initiatesdnademethylationindifferentiatingmonocytesatbothstableandtransientbindingsites AT johannaraithel epigeneticpioneeregr2initiatesdnademethylationindifferentiatingmonocytesatbothstableandtransientbindingsites AT juliawimmer epigeneticpioneeregr2initiatesdnademethylationindifferentiatingmonocytesatbothstableandtransientbindingsites AT claudiagebhard epigeneticpioneeregr2initiatesdnademethylationindifferentiatingmonocytesatbothstableandtransientbindingsites AT michaelrehli epigeneticpioneeregr2initiatesdnademethylationindifferentiatingmonocytesatbothstableandtransientbindingsites
_version_	1718393401037029376

The epigenetic pioneer EGR2 initiates DNA demethylation in differentiating monocytes at both stable and transient binding sites

Ejemplares similares