Integrin-αV-mediated activation of TGF-β regulates anti-tumour CD8 T cell immunity and response to PD-1 blockade

Response to PD-1 checkpoint blockade is unpredictable in lung cancer patients. Here authors show in human lung and mouse tumour models that low or absent αV integrin expression leads to better tumour growth control by anti-PD-1 via reduced TGF-β activation and hence increased infiltration of anti-tu...

Full description

Saved in:

Bibliographic Details
Main Authors:	Ines Malenica, Julien Adam, Stéphanie Corgnac, Laura Mezquita, Edouard Auclin, Isabelle Damei, Laetitia Grynszpan, Gwendoline Gros, Vincent de Montpréville, David Planchard, Nathalie Théret, Benjamin Besse, Fathia Mami-Chouaib
Format:	article
Language:	EN
Published:	Nature Portfolio 2021
Subjects:	Science Q
Online Access:	https://doaj.org/article/9f76efab27fb4f01b8031919754f4805
Tags:	Add Tag No Tags, Be the first to tag this record!

id	oai:doaj.org-article:9f76efab27fb4f01b8031919754f4805
record_format	dspace
spelling	oai:doaj.org-article:9f76efab27fb4f01b8031919754f48052021-12-02T19:09:54ZIntegrin-αV-mediated activation of TGF-β regulates anti-tumour CD8 T cell immunity and response to PD-1 blockade10.1038/s41467-021-25322-y2041-1723https://doaj.org/article/9f76efab27fb4f01b8031919754f48052021-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25322-yhttps://doaj.org/toc/2041-1723Response to PD-1 checkpoint blockade is unpredictable in lung cancer patients. Here authors show in human lung and mouse tumour models that low or absent αV integrin expression leads to better tumour growth control by anti-PD-1 via reduced TGF-β activation and hence increased infiltration of anti-tumour CD8+ T cells.Ines MalenicaJulien AdamStéphanie CorgnacLaura MezquitaEdouard AuclinIsabelle DameiLaetitia GrynszpanGwendoline GrosVincent de MontprévilleDavid PlanchardNathalie ThéretBenjamin BesseFathia Mami-ChouaibNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ines Malenica Julien Adam Stéphanie Corgnac Laura Mezquita Edouard Auclin Isabelle Damei Laetitia Grynszpan Gwendoline Gros Vincent de Montpréville David Planchard Nathalie Théret Benjamin Besse Fathia Mami-Chouaib Integrin-αV-mediated activation of TGF-β regulates anti-tumour CD8 T cell immunity and response to PD-1 blockade
description	Response to PD-1 checkpoint blockade is unpredictable in lung cancer patients. Here authors show in human lung and mouse tumour models that low or absent αV integrin expression leads to better tumour growth control by anti-PD-1 via reduced TGF-β activation and hence increased infiltration of anti-tumour CD8+ T cells.
format	article
author	Ines Malenica Julien Adam Stéphanie Corgnac Laura Mezquita Edouard Auclin Isabelle Damei Laetitia Grynszpan Gwendoline Gros Vincent de Montpréville David Planchard Nathalie Théret Benjamin Besse Fathia Mami-Chouaib
author_facet	Ines Malenica Julien Adam Stéphanie Corgnac Laura Mezquita Edouard Auclin Isabelle Damei Laetitia Grynszpan Gwendoline Gros Vincent de Montpréville David Planchard Nathalie Théret Benjamin Besse Fathia Mami-Chouaib
author_sort	Ines Malenica
title	Integrin-αV-mediated activation of TGF-β regulates anti-tumour CD8 T cell immunity and response to PD-1 blockade
title_short	Integrin-αV-mediated activation of TGF-β regulates anti-tumour CD8 T cell immunity and response to PD-1 blockade
title_full	Integrin-αV-mediated activation of TGF-β regulates anti-tumour CD8 T cell immunity and response to PD-1 blockade
title_fullStr	Integrin-αV-mediated activation of TGF-β regulates anti-tumour CD8 T cell immunity and response to PD-1 blockade
title_full_unstemmed	Integrin-αV-mediated activation of TGF-β regulates anti-tumour CD8 T cell immunity and response to PD-1 blockade
title_sort	integrin-αv-mediated activation of tgf-β regulates anti-tumour cd8 t cell immunity and response to pd-1 blockade
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/9f76efab27fb4f01b8031919754f4805
work_keys_str_mv	AT inesmalenica integrinavmediatedactivationoftgfbregulatesantitumourcd8tcellimmunityandresponsetopd1blockade AT julienadam integrinavmediatedactivationoftgfbregulatesantitumourcd8tcellimmunityandresponsetopd1blockade AT stephaniecorgnac integrinavmediatedactivationoftgfbregulatesantitumourcd8tcellimmunityandresponsetopd1blockade AT lauramezquita integrinavmediatedactivationoftgfbregulatesantitumourcd8tcellimmunityandresponsetopd1blockade AT edouardauclin integrinavmediatedactivationoftgfbregulatesantitumourcd8tcellimmunityandresponsetopd1blockade AT isabelledamei integrinavmediatedactivationoftgfbregulatesantitumourcd8tcellimmunityandresponsetopd1blockade AT laetitiagrynszpan integrinavmediatedactivationoftgfbregulatesantitumourcd8tcellimmunityandresponsetopd1blockade AT gwendolinegros integrinavmediatedactivationoftgfbregulatesantitumourcd8tcellimmunityandresponsetopd1blockade AT vincentdemontpreville integrinavmediatedactivationoftgfbregulatesantitumourcd8tcellimmunityandresponsetopd1blockade AT davidplanchard integrinavmediatedactivationoftgfbregulatesantitumourcd8tcellimmunityandresponsetopd1blockade AT nathalietheret integrinavmediatedactivationoftgfbregulatesantitumourcd8tcellimmunityandresponsetopd1blockade AT benjaminbesse integrinavmediatedactivationoftgfbregulatesantitumourcd8tcellimmunityandresponsetopd1blockade AT fathiamamichouaib integrinavmediatedactivationoftgfbregulatesantitumourcd8tcellimmunityandresponsetopd1blockade
_version_	1718377105978294272

Integrin-αV-mediated activation of TGF-β regulates anti-tumour CD8 T cell immunity and response to PD-1 blockade

Similar Items