Prospective postmortem evaluation of 735 consecutive SARS-CoV-2-associated death cases
Abstract Coronavirus disease 19 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has become a global pandemic with significant mortality. Accurate information on the specific circumstances of death and whether patients died from or with SARS-CoV-2 is scarce. To dis...
Guardado en:
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Nature Portfolio
2021
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/9f793935ab5349388f6ec17a5c1adb68 |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:9f793935ab5349388f6ec17a5c1adb68 |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:9f793935ab5349388f6ec17a5c1adb682021-12-02T17:18:22ZProspective postmortem evaluation of 735 consecutive SARS-CoV-2-associated death cases10.1038/s41598-021-98499-32045-2322https://doaj.org/article/9f793935ab5349388f6ec17a5c1adb682021-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-98499-3https://doaj.org/toc/2045-2322Abstract Coronavirus disease 19 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has become a global pandemic with significant mortality. Accurate information on the specific circumstances of death and whether patients died from or with SARS-CoV-2 is scarce. To distinguish COVID-19 from non-COVID-19 deaths, we performed a systematic review of 735 SARS-CoV-2-associated deaths in Hamburg, Germany, from March to December 2020, using conventional autopsy, ultrasound-guided minimally invasive autopsy, postmortem computed tomography and medical records. Statistical analyses including multiple logistic regression were used to compare both cohorts. 84.1% (n = 618) were classified as COVID-19 deaths, 6.4% (n = 47) as non-COVID-19 deaths, 9.5% (n = 70) remained unclear. Median age of COVID-19 deaths was 83.0 years, 54.4% were male. In the autopsy group (n = 283), the majority died of pneumonia and/or diffuse alveolar damage (73.6%; n = 187). Thromboses were found in 39.2% (n = 62/158 cases), pulmonary embolism in 22.1% (n = 56/253 cases). In 2020, annual mortality in Hamburg was about 5.5% higher than in the previous 20 years, of which 3.4% (n = 618) represented COVID-19 deaths. Our study highlights the need for mortality surveillance and postmortem examinations. The vast majority of individuals who died directly from SARS-CoV-2 infection were of advanced age and had multiple comorbidities.Antonia FitzekJulia SchädlerEric DietzAlexandra RonMoritz GerlingAnna L. KammalLarissa LohnerCarla FalckDustin MöbiusHanna GoebelsAnna-Lina GerberdingAnn Sophie SchröderJan-Peter SperhakeAnke KleinDaniela FröbHerbert MushumbaSandra WilmesSven AndersInga KniepFabian HeinrichFelicia LangenwalderKira MeißnerPhiline LangeAntonia ZapfKlaus PüschelAxel HeinemannMarkus GlatzelJakob MatschkeMartin AepfelbacherMarc LütgehetmannStefan SteurerChristoph ThornsCarolin EdlerBenjamin OndruschkaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Medicine R Science Q |
| spellingShingle |
Medicine R Science Q Antonia Fitzek Julia Schädler Eric Dietz Alexandra Ron Moritz Gerling Anna L. Kammal Larissa Lohner Carla Falck Dustin Möbius Hanna Goebels Anna-Lina Gerberding Ann Sophie Schröder Jan-Peter Sperhake Anke Klein Daniela Fröb Herbert Mushumba Sandra Wilmes Sven Anders Inga Kniep Fabian Heinrich Felicia Langenwalder Kira Meißner Philine Lange Antonia Zapf Klaus Püschel Axel Heinemann Markus Glatzel Jakob Matschke Martin Aepfelbacher Marc Lütgehetmann Stefan Steurer Christoph Thorns Carolin Edler Benjamin Ondruschka Prospective postmortem evaluation of 735 consecutive SARS-CoV-2-associated death cases |
| description |
Abstract Coronavirus disease 19 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has become a global pandemic with significant mortality. Accurate information on the specific circumstances of death and whether patients died from or with SARS-CoV-2 is scarce. To distinguish COVID-19 from non-COVID-19 deaths, we performed a systematic review of 735 SARS-CoV-2-associated deaths in Hamburg, Germany, from March to December 2020, using conventional autopsy, ultrasound-guided minimally invasive autopsy, postmortem computed tomography and medical records. Statistical analyses including multiple logistic regression were used to compare both cohorts. 84.1% (n = 618) were classified as COVID-19 deaths, 6.4% (n = 47) as non-COVID-19 deaths, 9.5% (n = 70) remained unclear. Median age of COVID-19 deaths was 83.0 years, 54.4% were male. In the autopsy group (n = 283), the majority died of pneumonia and/or diffuse alveolar damage (73.6%; n = 187). Thromboses were found in 39.2% (n = 62/158 cases), pulmonary embolism in 22.1% (n = 56/253 cases). In 2020, annual mortality in Hamburg was about 5.5% higher than in the previous 20 years, of which 3.4% (n = 618) represented COVID-19 deaths. Our study highlights the need for mortality surveillance and postmortem examinations. The vast majority of individuals who died directly from SARS-CoV-2 infection were of advanced age and had multiple comorbidities. |
| format |
article |
| author |
Antonia Fitzek Julia Schädler Eric Dietz Alexandra Ron Moritz Gerling Anna L. Kammal Larissa Lohner Carla Falck Dustin Möbius Hanna Goebels Anna-Lina Gerberding Ann Sophie Schröder Jan-Peter Sperhake Anke Klein Daniela Fröb Herbert Mushumba Sandra Wilmes Sven Anders Inga Kniep Fabian Heinrich Felicia Langenwalder Kira Meißner Philine Lange Antonia Zapf Klaus Püschel Axel Heinemann Markus Glatzel Jakob Matschke Martin Aepfelbacher Marc Lütgehetmann Stefan Steurer Christoph Thorns Carolin Edler Benjamin Ondruschka |
| author_facet |
Antonia Fitzek Julia Schädler Eric Dietz Alexandra Ron Moritz Gerling Anna L. Kammal Larissa Lohner Carla Falck Dustin Möbius Hanna Goebels Anna-Lina Gerberding Ann Sophie Schröder Jan-Peter Sperhake Anke Klein Daniela Fröb Herbert Mushumba Sandra Wilmes Sven Anders Inga Kniep Fabian Heinrich Felicia Langenwalder Kira Meißner Philine Lange Antonia Zapf Klaus Püschel Axel Heinemann Markus Glatzel Jakob Matschke Martin Aepfelbacher Marc Lütgehetmann Stefan Steurer Christoph Thorns Carolin Edler Benjamin Ondruschka |
| author_sort |
Antonia Fitzek |
| title |
Prospective postmortem evaluation of 735 consecutive SARS-CoV-2-associated death cases |
| title_short |
Prospective postmortem evaluation of 735 consecutive SARS-CoV-2-associated death cases |
| title_full |
Prospective postmortem evaluation of 735 consecutive SARS-CoV-2-associated death cases |
| title_fullStr |
Prospective postmortem evaluation of 735 consecutive SARS-CoV-2-associated death cases |
| title_full_unstemmed |
Prospective postmortem evaluation of 735 consecutive SARS-CoV-2-associated death cases |
| title_sort |
prospective postmortem evaluation of 735 consecutive sars-cov-2-associated death cases |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/9f793935ab5349388f6ec17a5c1adb68 |
| work_keys_str_mv |
AT antoniafitzek prospectivepostmortemevaluationof735consecutivesarscov2associateddeathcases AT juliaschadler prospectivepostmortemevaluationof735consecutivesarscov2associateddeathcases AT ericdietz prospectivepostmortemevaluationof735consecutivesarscov2associateddeathcases AT alexandraron prospectivepostmortemevaluationof735consecutivesarscov2associateddeathcases AT moritzgerling prospectivepostmortemevaluationof735consecutivesarscov2associateddeathcases AT annalkammal prospectivepostmortemevaluationof735consecutivesarscov2associateddeathcases AT larissalohner prospectivepostmortemevaluationof735consecutivesarscov2associateddeathcases AT carlafalck prospectivepostmortemevaluationof735consecutivesarscov2associateddeathcases AT dustinmobius prospectivepostmortemevaluationof735consecutivesarscov2associateddeathcases AT hannagoebels prospectivepostmortemevaluationof735consecutivesarscov2associateddeathcases AT annalinagerberding prospectivepostmortemevaluationof735consecutivesarscov2associateddeathcases AT annsophieschroder prospectivepostmortemevaluationof735consecutivesarscov2associateddeathcases AT janpetersperhake prospectivepostmortemevaluationof735consecutivesarscov2associateddeathcases AT ankeklein prospectivepostmortemevaluationof735consecutivesarscov2associateddeathcases AT danielafrob prospectivepostmortemevaluationof735consecutivesarscov2associateddeathcases AT herbertmushumba prospectivepostmortemevaluationof735consecutivesarscov2associateddeathcases AT sandrawilmes prospectivepostmortemevaluationof735consecutivesarscov2associateddeathcases AT svenanders prospectivepostmortemevaluationof735consecutivesarscov2associateddeathcases AT ingakniep prospectivepostmortemevaluationof735consecutivesarscov2associateddeathcases AT fabianheinrich prospectivepostmortemevaluationof735consecutivesarscov2associateddeathcases AT felicialangenwalder prospectivepostmortemevaluationof735consecutivesarscov2associateddeathcases AT kirameißner prospectivepostmortemevaluationof735consecutivesarscov2associateddeathcases AT philinelange prospectivepostmortemevaluationof735consecutivesarscov2associateddeathcases AT antoniazapf prospectivepostmortemevaluationof735consecutivesarscov2associateddeathcases AT klauspuschel prospectivepostmortemevaluationof735consecutivesarscov2associateddeathcases AT axelheinemann prospectivepostmortemevaluationof735consecutivesarscov2associateddeathcases AT markusglatzel prospectivepostmortemevaluationof735consecutivesarscov2associateddeathcases AT jakobmatschke prospectivepostmortemevaluationof735consecutivesarscov2associateddeathcases AT martinaepfelbacher prospectivepostmortemevaluationof735consecutivesarscov2associateddeathcases AT marclutgehetmann prospectivepostmortemevaluationof735consecutivesarscov2associateddeathcases AT stefansteurer prospectivepostmortemevaluationof735consecutivesarscov2associateddeathcases AT christophthorns prospectivepostmortemevaluationof735consecutivesarscov2associateddeathcases AT carolinedler prospectivepostmortemevaluationof735consecutivesarscov2associateddeathcases AT benjaminondruschka prospectivepostmortemevaluationof735consecutivesarscov2associateddeathcases |
| _version_ |
1718381100630278144 |