Occipital neural dynamics in cannabis and alcohol use: independent effects of addiction

Abstract Alcohol and cannabis use disorder (AUD/CUD) are two of the most common addictive disorders. While studies are beginning to understand the neural changes related to acute and chronic use, few studies have examined the independent effects of AUD and CUD on neural oscillatory activity. We exam...

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Autores principales:	Brandon J. Lew, Anabel Salimian, Tony W. Wilson
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/9f7af3319b58452984ff4a2bc23088c3
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spelling	oai:doaj.org-article:9f7af3319b58452984ff4a2bc23088c32021-11-21T12:19:16ZOccipital neural dynamics in cannabis and alcohol use: independent effects of addiction10.1038/s41598-021-01493-y2045-2322https://doaj.org/article/9f7af3319b58452984ff4a2bc23088c32021-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-01493-yhttps://doaj.org/toc/2045-2322Abstract Alcohol and cannabis use disorder (AUD/CUD) are two of the most common addictive disorders. While studies are beginning to understand the neural changes related to acute and chronic use, few studies have examined the independent effects of AUD and CUD on neural oscillatory activity. We examined 45 adults who reported current use of both cannabis and alcohol. Participants underwent the SCID-V to determine whether they met criteria for AUD and/or CUD. Participants also completed a visual-spatial processing task while undergoing magnetoencephalography (MEG). ANCOVA with a 2 × 2 design was then used to identify the main effects of AUD and CUD on source-level oscillatory activity. Of the 45 adults, 17 met criteria for AUD, and 26 met criteria for CUD. All participants, including comparison groups, reported use of both cannabis and alcohol. Statistical analyses showed a main effect of AUD, such that participants with AUD displayed a blunted occipital alpha (8–16 Hz) response. Post-hoc testing showed this decreased alpha response was related to increased AUD symptoms, above and beyond amount of use. No effects of AUD or CUD were identified in visual theta or gamma activity. In conclusion, AUD was associated with reduced alpha responses and scaled with increasing severity, independent of CUD. These findings indicate that alpha oscillatory activity may play an integral part in networks affected by alcohol addiction.Brandon J. LewAnabel SalimianTony W. WilsonNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Brandon J. Lew Anabel Salimian Tony W. Wilson Occipital neural dynamics in cannabis and alcohol use: independent effects of addiction
description	Abstract Alcohol and cannabis use disorder (AUD/CUD) are two of the most common addictive disorders. While studies are beginning to understand the neural changes related to acute and chronic use, few studies have examined the independent effects of AUD and CUD on neural oscillatory activity. We examined 45 adults who reported current use of both cannabis and alcohol. Participants underwent the SCID-V to determine whether they met criteria for AUD and/or CUD. Participants also completed a visual-spatial processing task while undergoing magnetoencephalography (MEG). ANCOVA with a 2 × 2 design was then used to identify the main effects of AUD and CUD on source-level oscillatory activity. Of the 45 adults, 17 met criteria for AUD, and 26 met criteria for CUD. All participants, including comparison groups, reported use of both cannabis and alcohol. Statistical analyses showed a main effect of AUD, such that participants with AUD displayed a blunted occipital alpha (8–16 Hz) response. Post-hoc testing showed this decreased alpha response was related to increased AUD symptoms, above and beyond amount of use. No effects of AUD or CUD were identified in visual theta or gamma activity. In conclusion, AUD was associated with reduced alpha responses and scaled with increasing severity, independent of CUD. These findings indicate that alpha oscillatory activity may play an integral part in networks affected by alcohol addiction.
format	article
author	Brandon J. Lew Anabel Salimian Tony W. Wilson
author_facet	Brandon J. Lew Anabel Salimian Tony W. Wilson
author_sort	Brandon J. Lew
title	Occipital neural dynamics in cannabis and alcohol use: independent effects of addiction
title_short	Occipital neural dynamics in cannabis and alcohol use: independent effects of addiction
title_full	Occipital neural dynamics in cannabis and alcohol use: independent effects of addiction
title_fullStr	Occipital neural dynamics in cannabis and alcohol use: independent effects of addiction
title_full_unstemmed	Occipital neural dynamics in cannabis and alcohol use: independent effects of addiction
title_sort	occipital neural dynamics in cannabis and alcohol use: independent effects of addiction
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/9f7af3319b58452984ff4a2bc23088c3
work_keys_str_mv	AT brandonjlew occipitalneuraldynamicsincannabisandalcoholuseindependenteffectsofaddiction AT anabelsalimian occipitalneuraldynamicsincannabisandalcoholuseindependenteffectsofaddiction AT tonywwilson occipitalneuraldynamicsincannabisandalcoholuseindependenteffectsofaddiction
_version_	1718419083607670784

Occipital neural dynamics in cannabis and alcohol use: independent effects of addiction

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