From experimental biomodeling to personalized medicine

This article presents the results of experimental studies of adverse effects of environmental and occupational exposures on the morphofunctional state of the central nervous system in offspring rats. The results of this study show that newborn offspring of rats exposed to vinyl chloride and mercuric...

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Autores principales:	V. S. Rukavishnikov, L. M. Sosedova, E. A. Kapustina, V. A. Vokina, E. A. Titov, N. L. Yakimova
Formato:	article
Lenguaje:	RU
Publicado:	Scientific Сentre for Family Health and Human Reproduction Problems 2013
Materias:	albino rats vinyl chloride mercuric chloride toluene prenatal hypoxia descendants nervous system Science Q
Acceso en línea:	https://doaj.org/article/9f7ca2c68fc847359ae272f3fd82a5d9
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spelling	oai:doaj.org-article:9f7ca2c68fc847359ae272f3fd82a5d92021-11-23T06:14:27ZFrom experimental biomodeling to personalized medicine2541-94202587-9596https://doaj.org/article/9f7ca2c68fc847359ae272f3fd82a5d92013-05-01T00:00:00Zhttps://www.actabiomedica.ru/jour/article/view/1504https://doaj.org/toc/2541-9420https://doaj.org/toc/2587-9596This article presents the results of experimental studies of adverse effects of environmental and occupational exposures on the morphofunctional state of the central nervous system in offspring rats. The results of this study show that newborn offspring of rats exposed to vinyl chloride and mercuric chloride lagged behind the controls in sensory-motor development. There was violated the whole structure of behavior in adult offspring characterized by reduces motor and exploratory activity, increased anxiety in rats. There was abnormal impulse conduction in the neuromuscular apparatus of the hind legs of albino rats and morphological changes in the structure of nervous tissue. Developmental disorders in the offspring may be associated with the processes of accumulation, influence on the genetic apparatus of cells or mediated by epigenetic mechanisms of CNS disorders. A comparative study of the behavioral and cognitive effects of toluene, cerebral bioelectrical activity in rats with a normal embryogenesis and background prenatal hypoxia has been found that toluene neurotoxicity are more pronounced in adult rats exposed to chronic prenatal hypoxia. The results suggest a possible decrease in the sensitivity of neurons to the action of neurotoxicants because of prenatal hypoxic damage. The significance of experimental modeling is to develop approaches to personalized medicine, because knowledge of the previous prenatal pathology or neurointoxication of parents allow study of individual measures of prevention, treatment, and decisions about employment of the younger generation.V. S. RukavishnikovL. M. SosedovaE. A. KapustinaV. A. VokinaE. A. TitovN. L. YakimovaScientific Сentre for Family Health and Human Reproduction Problemsarticlealbino ratsvinyl chloridemercuric chloridetolueneprenatal hypoxiadescendantsnervous systemScienceQRUActa Biomedica Scientifica, Vol 0, Iss 3(2), Pp 125-129 (2013)
institution	DOAJ
collection	DOAJ
language	RU
topic	albino rats vinyl chloride mercuric chloride toluene prenatal hypoxia descendants nervous system Science Q
spellingShingle	albino rats vinyl chloride mercuric chloride toluene prenatal hypoxia descendants nervous system Science Q V. S. Rukavishnikov L. M. Sosedova E. A. Kapustina V. A. Vokina E. A. Titov N. L. Yakimova From experimental biomodeling to personalized medicine
description	This article presents the results of experimental studies of adverse effects of environmental and occupational exposures on the morphofunctional state of the central nervous system in offspring rats. The results of this study show that newborn offspring of rats exposed to vinyl chloride and mercuric chloride lagged behind the controls in sensory-motor development. There was violated the whole structure of behavior in adult offspring characterized by reduces motor and exploratory activity, increased anxiety in rats. There was abnormal impulse conduction in the neuromuscular apparatus of the hind legs of albino rats and morphological changes in the structure of nervous tissue. Developmental disorders in the offspring may be associated with the processes of accumulation, influence on the genetic apparatus of cells or mediated by epigenetic mechanisms of CNS disorders. A comparative study of the behavioral and cognitive effects of toluene, cerebral bioelectrical activity in rats with a normal embryogenesis and background prenatal hypoxia has been found that toluene neurotoxicity are more pronounced in adult rats exposed to chronic prenatal hypoxia. The results suggest a possible decrease in the sensitivity of neurons to the action of neurotoxicants because of prenatal hypoxic damage. The significance of experimental modeling is to develop approaches to personalized medicine, because knowledge of the previous prenatal pathology or neurointoxication of parents allow study of individual measures of prevention, treatment, and decisions about employment of the younger generation.
format	article
author	V. S. Rukavishnikov L. M. Sosedova E. A. Kapustina V. A. Vokina E. A. Titov N. L. Yakimova
author_facet	V. S. Rukavishnikov L. M. Sosedova E. A. Kapustina V. A. Vokina E. A. Titov N. L. Yakimova
author_sort	V. S. Rukavishnikov
title	From experimental biomodeling to personalized medicine
title_short	From experimental biomodeling to personalized medicine
title_full	From experimental biomodeling to personalized medicine
title_fullStr	From experimental biomodeling to personalized medicine
title_full_unstemmed	From experimental biomodeling to personalized medicine
title_sort	from experimental biomodeling to personalized medicine
publisher	Scientific Сentre for Family Health and Human Reproduction Problems
publishDate	2013
url	https://doaj.org/article/9f7ca2c68fc847359ae272f3fd82a5d9
work_keys_str_mv	AT vsrukavishnikov fromexperimentalbiomodelingtopersonalizedmedicine AT lmsosedova fromexperimentalbiomodelingtopersonalizedmedicine AT eakapustina fromexperimentalbiomodelingtopersonalizedmedicine AT vavokina fromexperimentalbiomodelingtopersonalizedmedicine AT eatitov fromexperimentalbiomodelingtopersonalizedmedicine AT nlyakimova fromexperimentalbiomodelingtopersonalizedmedicine
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From experimental biomodeling to personalized medicine

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