RNF208, an estrogen-inducible E3 ligase, targets soluble Vimentin to suppress metastasis in triple-negative breast cancers

Triple-negative breast cancer (TNBC) is an aggressive subtype lacking effective targeted therapies. Here, the authors show that RNF208, an estrogen-induced ubiquitin ligase, promotes the degradation of Vimentin, thereby suppressing lung metastasis of TNBC, and may serve as a biomarker for the diseas...

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Autores principales:	Kyoungwha Pang, Jinah Park, Sung Gwe Ahn, Jihee Lee, Yuna Park, Akira Ooshima, Seiya Mizuno, Satoshi Yamashita, Kyung-Soon Park, So-Young Lee, Joon Jeong, Toshikazu Ushijima, Kyung-Min Yang, Seong-Jin Kim
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/9f80aa90665541f5b148e27077feb9a0
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spelling	oai:doaj.org-article:9f80aa90665541f5b148e27077feb9a02021-12-02T17:01:44ZRNF208, an estrogen-inducible E3 ligase, targets soluble Vimentin to suppress metastasis in triple-negative breast cancers10.1038/s41467-019-13852-52041-1723https://doaj.org/article/9f80aa90665541f5b148e27077feb9a02019-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13852-5https://doaj.org/toc/2041-1723Triple-negative breast cancer (TNBC) is an aggressive subtype lacking effective targeted therapies. Here, the authors show that RNF208, an estrogen-induced ubiquitin ligase, promotes the degradation of Vimentin, thereby suppressing lung metastasis of TNBC, and may serve as a biomarker for the disease.Kyoungwha PangJinah ParkSung Gwe AhnJihee LeeYuna ParkAkira OoshimaSeiya MizunoSatoshi YamashitaKyung-Soon ParkSo-Young LeeJoon JeongToshikazu UshijimaKyung-Min YangSeong-Jin KimNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Kyoungwha Pang Jinah Park Sung Gwe Ahn Jihee Lee Yuna Park Akira Ooshima Seiya Mizuno Satoshi Yamashita Kyung-Soon Park So-Young Lee Joon Jeong Toshikazu Ushijima Kyung-Min Yang Seong-Jin Kim RNF208, an estrogen-inducible E3 ligase, targets soluble Vimentin to suppress metastasis in triple-negative breast cancers
description	Triple-negative breast cancer (TNBC) is an aggressive subtype lacking effective targeted therapies. Here, the authors show that RNF208, an estrogen-induced ubiquitin ligase, promotes the degradation of Vimentin, thereby suppressing lung metastasis of TNBC, and may serve as a biomarker for the disease.
format	article
author	Kyoungwha Pang Jinah Park Sung Gwe Ahn Jihee Lee Yuna Park Akira Ooshima Seiya Mizuno Satoshi Yamashita Kyung-Soon Park So-Young Lee Joon Jeong Toshikazu Ushijima Kyung-Min Yang Seong-Jin Kim
author_facet	Kyoungwha Pang Jinah Park Sung Gwe Ahn Jihee Lee Yuna Park Akira Ooshima Seiya Mizuno Satoshi Yamashita Kyung-Soon Park So-Young Lee Joon Jeong Toshikazu Ushijima Kyung-Min Yang Seong-Jin Kim
author_sort	Kyoungwha Pang
title	RNF208, an estrogen-inducible E3 ligase, targets soluble Vimentin to suppress metastasis in triple-negative breast cancers
title_short	RNF208, an estrogen-inducible E3 ligase, targets soluble Vimentin to suppress metastasis in triple-negative breast cancers
title_full	RNF208, an estrogen-inducible E3 ligase, targets soluble Vimentin to suppress metastasis in triple-negative breast cancers
title_fullStr	RNF208, an estrogen-inducible E3 ligase, targets soluble Vimentin to suppress metastasis in triple-negative breast cancers
title_full_unstemmed	RNF208, an estrogen-inducible E3 ligase, targets soluble Vimentin to suppress metastasis in triple-negative breast cancers
title_sort	rnf208, an estrogen-inducible e3 ligase, targets soluble vimentin to suppress metastasis in triple-negative breast cancers
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/9f80aa90665541f5b148e27077feb9a0
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RNF208, an estrogen-inducible E3 ligase, targets soluble Vimentin to suppress metastasis in triple-negative breast cancers

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