Contrast-Enhanced Intraoperative Ultrasonography with Kupffer Phase May Change Treatment Strategy of Metastatic Liver Tumors – A Single-Centre Prospective Study
Chen Li,1 Yuan Liu,1 Jingyong Xu,2 Jinghai Song,2 Mingxiao Wu,1 Jian Chen2 1Department of Ultrasonography, Beijing Hospital, National Centre of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, 100730, People’s Republic of China; 2Department of General Surge...
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2021
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oai:doaj.org-article:9f829916e5df4df7b38e5a80115a5e6f2021-12-02T16:31:05ZContrast-Enhanced Intraoperative Ultrasonography with Kupffer Phase May Change Treatment Strategy of Metastatic Liver Tumors – A Single-Centre Prospective Study1178-203Xhttps://doaj.org/article/9f829916e5df4df7b38e5a80115a5e6f2021-07-01T00:00:00Zhttps://www.dovepress.com/contrast-enhanced-intraoperative-ultrasonography-with-kupffer-phase-ma-peer-reviewed-fulltext-article-TCRMhttps://doaj.org/toc/1178-203XChen Li,1 Yuan Liu,1 Jingyong Xu,2 Jinghai Song,2 Mingxiao Wu,1 Jian Chen2 1Department of Ultrasonography, Beijing Hospital, National Centre of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, 100730, People’s Republic of China; 2Department of General Surgery, Beijing Hospital, National Centre of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, 100730, People’s Republic of ChinaCorrespondence: Jingyong XuDepartment of General Surgery, Beijing Hospital, No. 1, Dahua Road, Dongdan, Beijing, 100730, People’s Republic of ChinaTel +86 13810351797Email xujingyong@bjhmoh.cnAim: To compare the diagnostic performance of contrast-enhanced intraoperative ultrasonography (CE-IOUS) with Kupffer phase in metastatic liver tumours.Methods: Twenty-seven consecutive patients with liver metastasis were prospectively recruited from November 2019 to July 2020 in the Department of HPB, Beijing Hospital. MRI and Contrast Enhanced Ultrasonography (CEUS) were obtained preoperatively, and the diagnosis was made by radiologists independently and blindly. Intraoperative ultrasonography (IOUS) and CE-IOUS with Sonazoid were done by the same sophisticated surgeon and sonographer and Kupffer phase was used to detect lesions. The sensitivity and specificity to detect lesions were compared between different radiologic methods. Then, the changes in treatment strategy due to CE-IOUS with Sonazoid were analysed.Results: Twenty-seven patients were included. In MRI, 91 lesions were detected with sensitivity 93.3% (70/75) and specificity 68.8% (11/16). In CEUS, it was 97.1% (68/70) and 86.7% (13/15) in 85 lesions. Meanwhile, in the Kupffer phase in CE-IOUS, 99 lesions were found and 8 new lesions were discovered in 7 cases, with sensitivity 97.5% (80/82) and specificity 94.1% (16/17). The four imaging methods showed no statistic significance in sensitivity and specificity in detecting lesions (Cochran’s Q 10.825, P=0.055). Treatment strategies were altered in 7 patients, 6 achieved R0 resection or ablation, and 1 patient changed from planned R0 resection to palliative surgery.Conclusion: CE-IOUS may play a similar or even better role than other radiological methods in diagnosing liver metastasis. The CE-IOUS using Sonazoid demonstrated a high sensitivity and specificity for finding occult metastases intraoperatively and changing the treatment strategy.Keywords: contrast-enhanced intraoperative ultrasonography, Kupffer phase, liver metastasis, SonazoidLi CLiu YXu JSong JWu MChen JDove Medical Pressarticlecontrast-enhanced intraoperative ultrasonographykupffer phaseliver metastasisTherapeutics. PharmacologyRM1-950ENTherapeutics and Clinical Risk Management, Vol Volume 17, Pp 789-796 (2021) |
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contrast-enhanced intraoperative ultrasonography kupffer phase liver metastasis Therapeutics. Pharmacology RM1-950 |
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contrast-enhanced intraoperative ultrasonography kupffer phase liver metastasis Therapeutics. Pharmacology RM1-950 Li C Liu Y Xu J Song J Wu M Chen J Contrast-Enhanced Intraoperative Ultrasonography with Kupffer Phase May Change Treatment Strategy of Metastatic Liver Tumors – A Single-Centre Prospective Study |
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Chen Li,1 Yuan Liu,1 Jingyong Xu,2 Jinghai Song,2 Mingxiao Wu,1 Jian Chen2 1Department of Ultrasonography, Beijing Hospital, National Centre of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, 100730, People’s Republic of China; 2Department of General Surgery, Beijing Hospital, National Centre of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, 100730, People’s Republic of ChinaCorrespondence: Jingyong XuDepartment of General Surgery, Beijing Hospital, No. 1, Dahua Road, Dongdan, Beijing, 100730, People’s Republic of ChinaTel +86 13810351797Email xujingyong@bjhmoh.cnAim: To compare the diagnostic performance of contrast-enhanced intraoperative ultrasonography (CE-IOUS) with Kupffer phase in metastatic liver tumours.Methods: Twenty-seven consecutive patients with liver metastasis were prospectively recruited from November 2019 to July 2020 in the Department of HPB, Beijing Hospital. MRI and Contrast Enhanced Ultrasonography (CEUS) were obtained preoperatively, and the diagnosis was made by radiologists independently and blindly. Intraoperative ultrasonography (IOUS) and CE-IOUS with Sonazoid were done by the same sophisticated surgeon and sonographer and Kupffer phase was used to detect lesions. The sensitivity and specificity to detect lesions were compared between different radiologic methods. Then, the changes in treatment strategy due to CE-IOUS with Sonazoid were analysed.Results: Twenty-seven patients were included. In MRI, 91 lesions were detected with sensitivity 93.3% (70/75) and specificity 68.8% (11/16). In CEUS, it was 97.1% (68/70) and 86.7% (13/15) in 85 lesions. Meanwhile, in the Kupffer phase in CE-IOUS, 99 lesions were found and 8 new lesions were discovered in 7 cases, with sensitivity 97.5% (80/82) and specificity 94.1% (16/17). The four imaging methods showed no statistic significance in sensitivity and specificity in detecting lesions (Cochran’s Q 10.825, P=0.055). Treatment strategies were altered in 7 patients, 6 achieved R0 resection or ablation, and 1 patient changed from planned R0 resection to palliative surgery.Conclusion: CE-IOUS may play a similar or even better role than other radiological methods in diagnosing liver metastasis. The CE-IOUS using Sonazoid demonstrated a high sensitivity and specificity for finding occult metastases intraoperatively and changing the treatment strategy.Keywords: contrast-enhanced intraoperative ultrasonography, Kupffer phase, liver metastasis, Sonazoid |
| format |
article |
| author |
Li C Liu Y Xu J Song J Wu M Chen J |
| author_facet |
Li C Liu Y Xu J Song J Wu M Chen J |
| author_sort |
Li C |
| title |
Contrast-Enhanced Intraoperative Ultrasonography with Kupffer Phase May Change Treatment Strategy of Metastatic Liver Tumors – A Single-Centre Prospective Study |
| title_short |
Contrast-Enhanced Intraoperative Ultrasonography with Kupffer Phase May Change Treatment Strategy of Metastatic Liver Tumors – A Single-Centre Prospective Study |
| title_full |
Contrast-Enhanced Intraoperative Ultrasonography with Kupffer Phase May Change Treatment Strategy of Metastatic Liver Tumors – A Single-Centre Prospective Study |
| title_fullStr |
Contrast-Enhanced Intraoperative Ultrasonography with Kupffer Phase May Change Treatment Strategy of Metastatic Liver Tumors – A Single-Centre Prospective Study |
| title_full_unstemmed |
Contrast-Enhanced Intraoperative Ultrasonography with Kupffer Phase May Change Treatment Strategy of Metastatic Liver Tumors – A Single-Centre Prospective Study |
| title_sort |
contrast-enhanced intraoperative ultrasonography with kupffer phase may change treatment strategy of metastatic liver tumors – a single-centre prospective study |
| publisher |
Dove Medical Press |
| publishDate |
2021 |
| url |
https://doaj.org/article/9f829916e5df4df7b38e5a80115a5e6f |
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