Chromatin network retards nucleoli coalescence

Nuclear bodies are membraneless condensates that may form via liquid-liquid phase separation; however, they defy theoretical predictions where the equilibrium state should consist of a single droplet. Here the authors use a diploid human genome model parameterized with Hi-C data to simulate nucleoli...

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Autores principales:	Yifeng Qi, Bin Zhang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/9f82bee6f2d04fb5bf091eab18be0a2d
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spelling	oai:doaj.org-article:9f82bee6f2d04fb5bf091eab18be0a2d2021-11-28T12:32:58ZChromatin network retards nucleoli coalescence10.1038/s41467-021-27123-92041-1723https://doaj.org/article/9f82bee6f2d04fb5bf091eab18be0a2d2021-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-27123-9https://doaj.org/toc/2041-1723Nuclear bodies are membraneless condensates that may form via liquid-liquid phase separation; however, they defy theoretical predictions where the equilibrium state should consist of a single droplet. Here the authors use a diploid human genome model parameterized with Hi-C data to simulate nucleoli formation. Their model suggests the chromatin network allows for existence of multiple droplets.Yifeng QiBin ZhangNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yifeng Qi Bin Zhang Chromatin network retards nucleoli coalescence
description	Nuclear bodies are membraneless condensates that may form via liquid-liquid phase separation; however, they defy theoretical predictions where the equilibrium state should consist of a single droplet. Here the authors use a diploid human genome model parameterized with Hi-C data to simulate nucleoli formation. Their model suggests the chromatin network allows for existence of multiple droplets.
format	article
author	Yifeng Qi Bin Zhang
author_facet	Yifeng Qi Bin Zhang
author_sort	Yifeng Qi
title	Chromatin network retards nucleoli coalescence
title_short	Chromatin network retards nucleoli coalescence
title_full	Chromatin network retards nucleoli coalescence
title_fullStr	Chromatin network retards nucleoli coalescence
title_full_unstemmed	Chromatin network retards nucleoli coalescence
title_sort	chromatin network retards nucleoli coalescence
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/9f82bee6f2d04fb5bf091eab18be0a2d
work_keys_str_mv	AT yifengqi chromatinnetworkretardsnucleolicoalescence AT binzhang chromatinnetworkretardsnucleolicoalescence
_version_	1718407908451942400

Chromatin network retards nucleoli coalescence

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