Exploring the Chemical Profiles and Biological Values of Two Spondias Species (S. dulcis and S. mombin): Valuable Sources of Bioactive Natural Products

Spondias species have been used in traditional medicine for different human ailments. In this study, the effect of different solvents (ethyl acetate, methanol, and water) and extraction methods (infusion, maceration, and Soxhlet extraction) on the enzyme inhibitory activity agains...

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Autores principales:	Kouadio Ibrahime Sinan, Gokhan Zengin, Dimitrina Zheleva-Dimitrova, Reneta Gevrenova, Marie Carene Nancy Picot-Allain, Stefano Dall’Acqua, Tapan Behl, Bey Hing Goh, Patrick Tang Siah Ying, Mohamad Fawzi Mahomoodally
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	<i>Spondias</i> enzyme inhibition gallic acid natural antioxidants bioactive agents Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/9f82df3f3cc64adaa1a5360d4a2f276b
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spelling	oai:doaj.org-article:9f82df3f3cc64adaa1a5360d4a2f276b2021-11-25T16:28:09ZExploring the Chemical Profiles and Biological Values of Two <i>Spondias</i> Species (<i>S. dulcis</i> and <i>S. mombin</i>): Valuable Sources of Bioactive Natural Products10.3390/antiox101117712076-3921https://doaj.org/article/9f82df3f3cc64adaa1a5360d4a2f276b2021-11-01T00:00:00Zhttps://www.mdpi.com/2076-3921/10/11/1771https://doaj.org/toc/2076-3921<i>Spondias</i> species have been used in traditional medicine for different human ailments. In this study, the effect of different solvents (ethyl acetate, methanol, and water) and extraction methods (infusion, maceration, and Soxhlet extraction) on the enzyme inhibitory activity against acetylcholinesterase, butyrylcholinesterase, tyrosinase, α-amylase, α-glucosidase, and antioxidant properties of <i>S. mombin</i> and <i>S. dulcis</i> leaves and stem bark were evaluated. Ultra-high-performance liquid chromatography–high resolution mass spectrometry (UHPLC-HRMS) yield in the identification and/or annotation of 98 compounds showing that the main secondary metabolites of the plant are gallic and ellagic acids and their derivatives, ellagitannins, hydroxybenzoic, hydroxycinnamic, acylquinic acids and flavonols, flavanones, and flavanonols. The leaves infusion of both <i>Spondias</i> species showed highest inhibition against acetylcholinesterase (AChE) (10.10 and 10.45 mg galantamine equivalent (GALAE)/g, for <i>S. dulcis</i> and <i>S. mombin</i>, respectively). The ethyl acetate extracts of the stem bark of <i>S. mombin</i> and <i>S. dulcis</i> actively inhibited α-glucosidase. Methanolic extracts of the leaves and stem bark exhibited highest tyrosinase inhibitory action. Antioxidant activity and higher levels of phenolics were observed for the methanolic extracts of <i>Spondias.</i> The results suggested that the <i>Spondias</i> species could be considered as natural phyto-therapeutic agents in medicinal and cosmeceutical applications.Kouadio Ibrahime SinanGokhan ZenginDimitrina Zheleva-DimitrovaReneta GevrenovaMarie Carene Nancy Picot-AllainStefano Dall’AcquaTapan BehlBey Hing GohPatrick Tang Siah YingMohamad Fawzi MahomoodallyMDPI AGarticle<i>Spondias</i>enzyme inhibitiongallic acidnatural antioxidantsbioactive agentsTherapeutics. PharmacologyRM1-950ENAntioxidants, Vol 10, Iss 1771, p 1771 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	<i>Spondias</i> enzyme inhibition gallic acid natural antioxidants bioactive agents Therapeutics. Pharmacology RM1-950
spellingShingle	<i>Spondias</i> enzyme inhibition gallic acid natural antioxidants bioactive agents Therapeutics. Pharmacology RM1-950 Kouadio Ibrahime Sinan Gokhan Zengin Dimitrina Zheleva-Dimitrova Reneta Gevrenova Marie Carene Nancy Picot-Allain Stefano Dall’Acqua Tapan Behl Bey Hing Goh Patrick Tang Siah Ying Mohamad Fawzi Mahomoodally Exploring the Chemical Profiles and Biological Values of Two <i>Spondias</i> Species (<i>S. dulcis</i> and <i>S. mombin</i>): Valuable Sources of Bioactive Natural Products
description	<i>Spondias</i> species have been used in traditional medicine for different human ailments. In this study, the effect of different solvents (ethyl acetate, methanol, and water) and extraction methods (infusion, maceration, and Soxhlet extraction) on the enzyme inhibitory activity against acetylcholinesterase, butyrylcholinesterase, tyrosinase, α-amylase, α-glucosidase, and antioxidant properties of <i>S. mombin</i> and <i>S. dulcis</i> leaves and stem bark were evaluated. Ultra-high-performance liquid chromatography–high resolution mass spectrometry (UHPLC-HRMS) yield in the identification and/or annotation of 98 compounds showing that the main secondary metabolites of the plant are gallic and ellagic acids and their derivatives, ellagitannins, hydroxybenzoic, hydroxycinnamic, acylquinic acids and flavonols, flavanones, and flavanonols. The leaves infusion of both <i>Spondias</i> species showed highest inhibition against acetylcholinesterase (AChE) (10.10 and 10.45 mg galantamine equivalent (GALAE)/g, for <i>S. dulcis</i> and <i>S. mombin</i>, respectively). The ethyl acetate extracts of the stem bark of <i>S. mombin</i> and <i>S. dulcis</i> actively inhibited α-glucosidase. Methanolic extracts of the leaves and stem bark exhibited highest tyrosinase inhibitory action. Antioxidant activity and higher levels of phenolics were observed for the methanolic extracts of <i>Spondias.</i> The results suggested that the <i>Spondias</i> species could be considered as natural phyto-therapeutic agents in medicinal and cosmeceutical applications.
format	article
author	Kouadio Ibrahime Sinan Gokhan Zengin Dimitrina Zheleva-Dimitrova Reneta Gevrenova Marie Carene Nancy Picot-Allain Stefano Dall’Acqua Tapan Behl Bey Hing Goh Patrick Tang Siah Ying Mohamad Fawzi Mahomoodally
author_facet	Kouadio Ibrahime Sinan Gokhan Zengin Dimitrina Zheleva-Dimitrova Reneta Gevrenova Marie Carene Nancy Picot-Allain Stefano Dall’Acqua Tapan Behl Bey Hing Goh Patrick Tang Siah Ying Mohamad Fawzi Mahomoodally
author_sort	Kouadio Ibrahime Sinan
title	Exploring the Chemical Profiles and Biological Values of Two <i>Spondias</i> Species (<i>S. dulcis</i> and <i>S. mombin</i>): Valuable Sources of Bioactive Natural Products
title_short	Exploring the Chemical Profiles and Biological Values of Two <i>Spondias</i> Species (<i>S. dulcis</i> and <i>S. mombin</i>): Valuable Sources of Bioactive Natural Products
title_full	Exploring the Chemical Profiles and Biological Values of Two <i>Spondias</i> Species (<i>S. dulcis</i> and <i>S. mombin</i>): Valuable Sources of Bioactive Natural Products
title_fullStr	Exploring the Chemical Profiles and Biological Values of Two <i>Spondias</i> Species (<i>S. dulcis</i> and <i>S. mombin</i>): Valuable Sources of Bioactive Natural Products
title_full_unstemmed	Exploring the Chemical Profiles and Biological Values of Two <i>Spondias</i> Species (<i>S. dulcis</i> and <i>S. mombin</i>): Valuable Sources of Bioactive Natural Products
title_sort	exploring the chemical profiles and biological values of two <i>spondias</i> species (<i>s. dulcis</i> and <i>s. mombin</i>): valuable sources of bioactive natural products
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/9f82df3f3cc64adaa1a5360d4a2f276b
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Exploring the Chemical Profiles and Biological Values of Two <i>Spondias</i> Species (<i>S. dulcis</i> and <i>S. mombin</i>): Valuable Sources of Bioactive Natural Products

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