Plasma microRNA markers of upper limb recovery following human stroke

Abstract Preclinical investigators have implicated several microRNAs as regulators of gene expression promoting neural plasticity following experimental stroke in rodent models. Our goal was to determine whether similar microRNAs might be identifiable in plasma of humans with variable recovery from...

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Autores principales:	Matthew A. Edwardson, Xiaogang Zhong, Massimo S. Fiandaca, Howard J. Federoff, Amrita K. Cheema, Alexander W. Dromerick
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/9f847088b66f4bda936c58861b0c0ecd
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spelling	oai:doaj.org-article:9f847088b66f4bda936c58861b0c0ecd2021-12-02T15:08:25ZPlasma microRNA markers of upper limb recovery following human stroke10.1038/s41598-018-31020-52045-2322https://doaj.org/article/9f847088b66f4bda936c58861b0c0ecd2018-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-31020-5https://doaj.org/toc/2045-2322Abstract Preclinical investigators have implicated several microRNAs as regulators of gene expression promoting neural plasticity following experimental stroke in rodent models. Our goal was to determine whether similar microRNAs might be identifiable in plasma of humans with variable recovery from stroke. Plasma was collected 19 days post-stroke from 27 participants with mild-moderate upper extremity impairment enrolled in the Critical Periods After Stroke Study (CPASS). MicroRNA expression was assessed using TaqMan microRNA assays. Good clinical recovery was defined as ≥6 point change in the Action Research Arm Test (ARAT) score from baseline to 6 months, with 22 subjects showing good and 5 showing poor recovery. When comparing the good versus poor recovery groups, six microRNAs showed significantly decreased expression – miR-371-3p, miR-524, miR-520g, miR-1255A, miR-453, and miR-583, while 3 showed significantly increased expression - miR-941, miR-449b, and miR-581. MiR-371-3p and miR-941 have previously been associated with neural repair mechanisms; none of the significant microRNAs have previously been associated with stroke. The 9 microRNAs converge on pathways associated with axonal guidance, developmental biology, and cancer. We conclude that plasma microRNAs may be informative regarding human neural repair mechanisms during stroke recovery and probably differ from those seen in experimental stroke models.Matthew A. EdwardsonXiaogang ZhongMassimo S. FiandacaHoward J. FederoffAmrita K. CheemaAlexander W. DromerickNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-7 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Matthew A. Edwardson Xiaogang Zhong Massimo S. Fiandaca Howard J. Federoff Amrita K. Cheema Alexander W. Dromerick Plasma microRNA markers of upper limb recovery following human stroke
description	Abstract Preclinical investigators have implicated several microRNAs as regulators of gene expression promoting neural plasticity following experimental stroke in rodent models. Our goal was to determine whether similar microRNAs might be identifiable in plasma of humans with variable recovery from stroke. Plasma was collected 19 days post-stroke from 27 participants with mild-moderate upper extremity impairment enrolled in the Critical Periods After Stroke Study (CPASS). MicroRNA expression was assessed using TaqMan microRNA assays. Good clinical recovery was defined as ≥6 point change in the Action Research Arm Test (ARAT) score from baseline to 6 months, with 22 subjects showing good and 5 showing poor recovery. When comparing the good versus poor recovery groups, six microRNAs showed significantly decreased expression – miR-371-3p, miR-524, miR-520g, miR-1255A, miR-453, and miR-583, while 3 showed significantly increased expression - miR-941, miR-449b, and miR-581. MiR-371-3p and miR-941 have previously been associated with neural repair mechanisms; none of the significant microRNAs have previously been associated with stroke. The 9 microRNAs converge on pathways associated with axonal guidance, developmental biology, and cancer. We conclude that plasma microRNAs may be informative regarding human neural repair mechanisms during stroke recovery and probably differ from those seen in experimental stroke models.
format	article
author	Matthew A. Edwardson Xiaogang Zhong Massimo S. Fiandaca Howard J. Federoff Amrita K. Cheema Alexander W. Dromerick
author_facet	Matthew A. Edwardson Xiaogang Zhong Massimo S. Fiandaca Howard J. Federoff Amrita K. Cheema Alexander W. Dromerick
author_sort	Matthew A. Edwardson
title	Plasma microRNA markers of upper limb recovery following human stroke
title_short	Plasma microRNA markers of upper limb recovery following human stroke
title_full	Plasma microRNA markers of upper limb recovery following human stroke
title_fullStr	Plasma microRNA markers of upper limb recovery following human stroke
title_full_unstemmed	Plasma microRNA markers of upper limb recovery following human stroke
title_sort	plasma microrna markers of upper limb recovery following human stroke
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/9f847088b66f4bda936c58861b0c0ecd
work_keys_str_mv	AT matthewaedwardson plasmamicrornamarkersofupperlimbrecoveryfollowinghumanstroke AT xiaogangzhong plasmamicrornamarkersofupperlimbrecoveryfollowinghumanstroke AT massimosfiandaca plasmamicrornamarkersofupperlimbrecoveryfollowinghumanstroke AT howardjfederoff plasmamicrornamarkersofupperlimbrecoveryfollowinghumanstroke AT amritakcheema plasmamicrornamarkersofupperlimbrecoveryfollowinghumanstroke AT alexanderwdromerick plasmamicrornamarkersofupperlimbrecoveryfollowinghumanstroke
_version_	1718388140537806848

Plasma microRNA markers of upper limb recovery following human stroke

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