Transdermal delivery of paeonol using cubic gel and microemulsion gel

Maofu Luo1,2, Qi Shen1, Jinjin Chen11School of Pharmacy, Shanghai Jiao Tong University, Shanghai, 2Jiangxi University of Traditional Chinese Medicine, Nanchang, People&rsquo;s Republic of ChinaBackground: The aim of this study was to develop new systems for transdermal delivery of paeonol, i...

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Autores principales:	Chen J, Shen Q, Luo M
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2011
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/9f84ea9e45db4b5398dc87bf831ba4df
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spelling	oai:doaj.org-article:9f84ea9e45db4b5398dc87bf831ba4df2021-12-02T01:42:40ZTransdermal delivery of paeonol using cubic gel and microemulsion gel1176-91141178-2013https://doaj.org/article/9f84ea9e45db4b5398dc87bf831ba4df2011-08-01T00:00:00Zhttp://www.dovepress.com/transdermal-delivery-of-paeonol-using-cubic-gel-and-microemulsion-gel-a8022https://doaj.org/toc/1176-9114https://doaj.org/toc/1178-2013Maofu Luo1,2, Qi Shen1, Jinjin Chen11School of Pharmacy, Shanghai Jiao Tong University, Shanghai, 2Jiangxi University of Traditional Chinese Medicine, Nanchang, People&rsquo;s Republic of ChinaBackground: The aim of this study was to develop new systems for transdermal delivery of paeonol, in particular microemulsion gel and cubic gel formulations.Methods: Various microemulsion vehicles were prepared using isopropyl myristate as an oil phase, polyoxyethylated castor oil (Cremophor&reg; EL) as a surfactant, and polyethylene glycol 400 as a cosurfactant. In the optimum microemulsion gel formulation, carbomer 940 was selected as the gel matrix, and consisted of 1% paeonol, 4% isopropyl myristate, 28% Cremophor EL/polyethylene glycol 400 (1:1), and 67% water. The cubic gel was prepared containing 3% paeonol, 30% water, and 67% glyceryl monooleate.Results: A skin permeability test using excised rat skins indicated that both the cubic gel and microemulsion gel formulations had higher permeability than did the paeonol solution. An in vivo pharmacokinetic study done in rats showed that the relative bioavailability of the cubic gel and microemulsion gel was enhanced by about 1.51-fold and 1.28-fold, respectively, compared with orally administered paeonol suspension.Conclusion: Both the cubic gel and microemulsion gel formulations are promising delivery systems to enhance the skin permeability of paeonol, in particular the cubic gel.Keywords: microemulsion gel, cubic gel, transdermal delivery, paeonolChen JShen QLuo MDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2011, Iss default, Pp 1603-1610 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Chen J Shen Q Luo M Transdermal delivery of paeonol using cubic gel and microemulsion gel
description	Maofu Luo1,2, Qi Shen1, Jinjin Chen11School of Pharmacy, Shanghai Jiao Tong University, Shanghai, 2Jiangxi University of Traditional Chinese Medicine, Nanchang, People&rsquo;s Republic of ChinaBackground: The aim of this study was to develop new systems for transdermal delivery of paeonol, in particular microemulsion gel and cubic gel formulations.Methods: Various microemulsion vehicles were prepared using isopropyl myristate as an oil phase, polyoxyethylated castor oil (Cremophor&reg; EL) as a surfactant, and polyethylene glycol 400 as a cosurfactant. In the optimum microemulsion gel formulation, carbomer 940 was selected as the gel matrix, and consisted of 1% paeonol, 4% isopropyl myristate, 28% Cremophor EL/polyethylene glycol 400 (1:1), and 67% water. The cubic gel was prepared containing 3% paeonol, 30% water, and 67% glyceryl monooleate.Results: A skin permeability test using excised rat skins indicated that both the cubic gel and microemulsion gel formulations had higher permeability than did the paeonol solution. An in vivo pharmacokinetic study done in rats showed that the relative bioavailability of the cubic gel and microemulsion gel was enhanced by about 1.51-fold and 1.28-fold, respectively, compared with orally administered paeonol suspension.Conclusion: Both the cubic gel and microemulsion gel formulations are promising delivery systems to enhance the skin permeability of paeonol, in particular the cubic gel.Keywords: microemulsion gel, cubic gel, transdermal delivery, paeonol
format	article
author	Chen J Shen Q Luo M
author_facet	Chen J Shen Q Luo M
author_sort	Chen J
title	Transdermal delivery of paeonol using cubic gel and microemulsion gel
title_short	Transdermal delivery of paeonol using cubic gel and microemulsion gel
title_full	Transdermal delivery of paeonol using cubic gel and microemulsion gel
title_fullStr	Transdermal delivery of paeonol using cubic gel and microemulsion gel
title_full_unstemmed	Transdermal delivery of paeonol using cubic gel and microemulsion gel
title_sort	transdermal delivery of paeonol using cubic gel and microemulsion gel
publisher	Dove Medical Press
publishDate	2011
url	https://doaj.org/article/9f84ea9e45db4b5398dc87bf831ba4df
work_keys_str_mv	AT chenj transdermaldeliveryofpaeonolusingcubicgelandmicroemulsiongel AT shenq transdermaldeliveryofpaeonolusingcubicgelandmicroemulsiongel AT luom transdermaldeliveryofpaeonolusingcubicgelandmicroemulsiongel
_version_	1718402910949212160

Transdermal delivery of paeonol using cubic gel and microemulsion gel

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