Cell specific delivery of modified mRNA expressing therapeutic proteins to leukocytes

Therapeutic alteration of protein expression using modified mRNA is limited by immunogenicity and instability in vivo. Here the authors use antibody-coated lipid nanoparticles to deliver mRNA to leukocytes and drive expression of anti-inflammatory cytokines in an inflammatory bowel disease mouse mod...

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Autores principales:	Nuphar Veiga, Meir Goldsmith, Yasmin Granot, Daniel Rosenblum, Niels Dammes, Ranit Kedmi, Srinivas Ramishetti, Dan Peer
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/9f873ddd64ac44b1bc45f41c3236a99a
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spelling	oai:doaj.org-article:9f873ddd64ac44b1bc45f41c3236a99a2021-12-02T17:32:34ZCell specific delivery of modified mRNA expressing therapeutic proteins to leukocytes10.1038/s41467-018-06936-12041-1723https://doaj.org/article/9f873ddd64ac44b1bc45f41c3236a99a2018-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06936-1https://doaj.org/toc/2041-1723Therapeutic alteration of protein expression using modified mRNA is limited by immunogenicity and instability in vivo. Here the authors use antibody-coated lipid nanoparticles to deliver mRNA to leukocytes and drive expression of anti-inflammatory cytokines in an inflammatory bowel disease mouse model.Nuphar VeigaMeir GoldsmithYasmin GranotDaniel RosenblumNiels DammesRanit KedmiSrinivas RamishettiDan PeerNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-9 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Nuphar Veiga Meir Goldsmith Yasmin Granot Daniel Rosenblum Niels Dammes Ranit Kedmi Srinivas Ramishetti Dan Peer Cell specific delivery of modified mRNA expressing therapeutic proteins to leukocytes
description	Therapeutic alteration of protein expression using modified mRNA is limited by immunogenicity and instability in vivo. Here the authors use antibody-coated lipid nanoparticles to deliver mRNA to leukocytes and drive expression of anti-inflammatory cytokines in an inflammatory bowel disease mouse model.
format	article
author	Nuphar Veiga Meir Goldsmith Yasmin Granot Daniel Rosenblum Niels Dammes Ranit Kedmi Srinivas Ramishetti Dan Peer
author_facet	Nuphar Veiga Meir Goldsmith Yasmin Granot Daniel Rosenblum Niels Dammes Ranit Kedmi Srinivas Ramishetti Dan Peer
author_sort	Nuphar Veiga
title	Cell specific delivery of modified mRNA expressing therapeutic proteins to leukocytes
title_short	Cell specific delivery of modified mRNA expressing therapeutic proteins to leukocytes
title_full	Cell specific delivery of modified mRNA expressing therapeutic proteins to leukocytes
title_fullStr	Cell specific delivery of modified mRNA expressing therapeutic proteins to leukocytes
title_full_unstemmed	Cell specific delivery of modified mRNA expressing therapeutic proteins to leukocytes
title_sort	cell specific delivery of modified mrna expressing therapeutic proteins to leukocytes
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/9f873ddd64ac44b1bc45f41c3236a99a
work_keys_str_mv	AT nupharveiga cellspecificdeliveryofmodifiedmrnaexpressingtherapeuticproteinstoleukocytes AT meirgoldsmith cellspecificdeliveryofmodifiedmrnaexpressingtherapeuticproteinstoleukocytes AT yasmingranot cellspecificdeliveryofmodifiedmrnaexpressingtherapeuticproteinstoleukocytes AT danielrosenblum cellspecificdeliveryofmodifiedmrnaexpressingtherapeuticproteinstoleukocytes AT nielsdammes cellspecificdeliveryofmodifiedmrnaexpressingtherapeuticproteinstoleukocytes AT ranitkedmi cellspecificdeliveryofmodifiedmrnaexpressingtherapeuticproteinstoleukocytes AT srinivasramishetti cellspecificdeliveryofmodifiedmrnaexpressingtherapeuticproteinstoleukocytes AT danpeer cellspecificdeliveryofmodifiedmrnaexpressingtherapeuticproteinstoleukocytes
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Cell specific delivery of modified mRNA expressing therapeutic proteins to leukocytes

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