Functional outcome of repeat Descemet membrane endothelial keratoplasty (DMEK) for corneal decompensation following graft failure after primary DMEK

Bishr Agha, Mehdi Shajari, Anna Slavik-Lencova, Thomas Kohnen, Ingo Schmack Department of Ophthalmology, Goethe-University, Frankfurt am Main, Germany Purpose: To evaluate if repeat Descemet membrane endothelial keratoplasty (DMEK) is appropriate to achieve functional improvements in patients with...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Agha B, Shajari M, Slavik-Lencova A, Kohnen T, Schmack I
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	DMEK repeat DMEK corneal edema corneal transplantation Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/9f8b4e57eacc4cb2bed18ffbeb2d251f
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:9f8b4e57eacc4cb2bed18ffbeb2d251f
record_format	dspace
spelling	oai:doaj.org-article:9f8b4e57eacc4cb2bed18ffbeb2d251f2021-12-02T08:14:38ZFunctional outcome of repeat Descemet membrane endothelial keratoplasty (DMEK) for corneal decompensation following graft failure after primary DMEK1177-5483https://doaj.org/article/9f8b4e57eacc4cb2bed18ffbeb2d251f2019-03-01T00:00:00Zhttps://www.dovepress.com/functional-outcome-of-repeat-descemet-membrane-endothelial-keratoplast-peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483Bishr Agha, Mehdi Shajari, Anna Slavik-Lencova, Thomas Kohnen, Ingo Schmack Department of Ophthalmology, Goethe-University, Frankfurt am Main, Germany Purpose: To evaluate if repeat Descemet membrane endothelial keratoplasty (DMEK) is appropriate to achieve functional improvements in patients with corneal decompensation from secondary graft failure after primary DMEK.Methods: This is a retrospective monocentric cohort study including 13 eyes of 13 patients with repeat DMEK for corneal decompensation following primary DMEK. Eyes with primary DMEK only and comparable preoperative corrected distance visual acuity (CDVA) served as control. Main outcome parameter was CDVA. Secondary outcome measures were central corneal thickness (CCT), endothelial cell density, and rebubbling rate (RR).Results: The average time interval (±SD) between primary and secondary DMEK was 12.5±6 months. Preoperative CDVA (logMAR) was 1.97±0.90 in the repeat DMEK group and 1.38±0.92 in the primary DMEK group. At 6 months, both groups showed significant improvement in visual acuity (repeat DMEK group, 0.49±0.35, P<0.01 and primary DMEK group, 0.40±0.36, P<0.01). CDVA did not differ significantly between both groups at all time points examined (1, 3, and 6 months postoperatively). Mean CCT values at 3 and 6 months postoperatively did not differ significantly between the two groups (P>0.05). The RR was23% (n=3) in both groups.Conclusion: Repeat DMEK is a useful therapeutic approach in the setting of corneal decompensation following primary DMEK. Functional results of repeat DMEK, visual acuity in particular, are comparable to patients with single DMEK only. Keywords: DMEK, repeat DMEK, corneal edema, corneal transplantation  Agha BShajari MSlavik-Lencova AKohnen TSchmack IDove Medical PressarticleDMEKrepeat DMEKcorneal edemacorneal transplantationOphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 13, Pp 477-482 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	DMEK repeat DMEK corneal edema corneal transplantation Ophthalmology RE1-994
spellingShingle	DMEK repeat DMEK corneal edema corneal transplantation Ophthalmology RE1-994 Agha B Shajari M Slavik-Lencova A Kohnen T Schmack I Functional outcome of repeat Descemet membrane endothelial keratoplasty (DMEK) for corneal decompensation following graft failure after primary DMEK
description	Bishr Agha, Mehdi Shajari, Anna Slavik-Lencova, Thomas Kohnen, Ingo Schmack Department of Ophthalmology, Goethe-University, Frankfurt am Main, Germany Purpose: To evaluate if repeat Descemet membrane endothelial keratoplasty (DMEK) is appropriate to achieve functional improvements in patients with corneal decompensation from secondary graft failure after primary DMEK.Methods: This is a retrospective monocentric cohort study including 13 eyes of 13 patients with repeat DMEK for corneal decompensation following primary DMEK. Eyes with primary DMEK only and comparable preoperative corrected distance visual acuity (CDVA) served as control. Main outcome parameter was CDVA. Secondary outcome measures were central corneal thickness (CCT), endothelial cell density, and rebubbling rate (RR).Results: The average time interval (±SD) between primary and secondary DMEK was 12.5±6 months. Preoperative CDVA (logMAR) was 1.97±0.90 in the repeat DMEK group and 1.38±0.92 in the primary DMEK group. At 6 months, both groups showed significant improvement in visual acuity (repeat DMEK group, 0.49±0.35, P<0.01 and primary DMEK group, 0.40±0.36, P<0.01). CDVA did not differ significantly between both groups at all time points examined (1, 3, and 6 months postoperatively). Mean CCT values at 3 and 6 months postoperatively did not differ significantly between the two groups (P>0.05). The RR was23% (n=3) in both groups.Conclusion: Repeat DMEK is a useful therapeutic approach in the setting of corneal decompensation following primary DMEK. Functional results of repeat DMEK, visual acuity in particular, are comparable to patients with single DMEK only. Keywords: DMEK, repeat DMEK, corneal edema, corneal transplantation
format	article
author	Agha B Shajari M Slavik-Lencova A Kohnen T Schmack I
author_facet	Agha B Shajari M Slavik-Lencova A Kohnen T Schmack I
author_sort	Agha B
title	Functional outcome of repeat Descemet membrane endothelial keratoplasty (DMEK) for corneal decompensation following graft failure after primary DMEK
title_short	Functional outcome of repeat Descemet membrane endothelial keratoplasty (DMEK) for corneal decompensation following graft failure after primary DMEK
title_full	Functional outcome of repeat Descemet membrane endothelial keratoplasty (DMEK) for corneal decompensation following graft failure after primary DMEK
title_fullStr	Functional outcome of repeat Descemet membrane endothelial keratoplasty (DMEK) for corneal decompensation following graft failure after primary DMEK
title_full_unstemmed	Functional outcome of repeat Descemet membrane endothelial keratoplasty (DMEK) for corneal decompensation following graft failure after primary DMEK
title_sort	functional outcome of repeat descemet membrane endothelial keratoplasty (dmek) for corneal decompensation following graft failure after primary dmek
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/9f8b4e57eacc4cb2bed18ffbeb2d251f
work_keys_str_mv	AT aghab functionaloutcomeofrepeatdescemetmembraneendothelialkeratoplastydmekforcornealdecompensationfollowinggraftfailureafterprimarydmek AT shajarim functionaloutcomeofrepeatdescemetmembraneendothelialkeratoplastydmekforcornealdecompensationfollowinggraftfailureafterprimarydmek AT slaviklencovaa functionaloutcomeofrepeatdescemetmembraneendothelialkeratoplastydmekforcornealdecompensationfollowinggraftfailureafterprimarydmek AT kohnent functionaloutcomeofrepeatdescemetmembraneendothelialkeratoplastydmekforcornealdecompensationfollowinggraftfailureafterprimarydmek AT schmacki functionaloutcomeofrepeatdescemetmembraneendothelialkeratoplastydmekforcornealdecompensationfollowinggraftfailureafterprimarydmek
_version_	1718398617096552448

Functional outcome of repeat Descemet membrane endothelial keratoplasty (DMEK) for corneal decompensation following graft failure after primary DMEK

Ejemplares similares