Association between biomarkers of bone health and osteosarcopenia among Iranian older people: The Bushehr Elderly Health (BEH) program

Abstract Background Osteosarcopenia is referred to as co-incidence of osteoporosis/osteopenia and sarcopenia which is defined as a geriatric syndrome with a significant prevalence that increases morbidity and mortality. There are some relevant factors that can show an increased risk of incidence of...

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Autores principales:	Maryam Fathi, Ramin Heshmat, Mehdi Ebrahimi, Ahmad Salimzadeh, Afshin Ostovar, Ali Fathi, Farideh Razi, Iraj Nabipour, Maryam Moghaddassi, Gita Shafiee
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Osteosarcopenia Bone turnover markers Older people Geriatrics RC952-954.6
Acceso en línea:	https://doaj.org/article/9f8b7a296435474c9de36ec6d216bad8
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spelling	oai:doaj.org-article:9f8b7a296435474c9de36ec6d216bad82021-11-21T12:07:28ZAssociation between biomarkers of bone health and osteosarcopenia among Iranian older people: The Bushehr Elderly Health (BEH) program10.1186/s12877-021-02608-w1471-2318https://doaj.org/article/9f8b7a296435474c9de36ec6d216bad82021-11-01T00:00:00Zhttps://doi.org/10.1186/s12877-021-02608-whttps://doaj.org/toc/1471-2318Abstract Background Osteosarcopenia is referred to as co-incidence of osteoporosis/osteopenia and sarcopenia which is defined as a geriatric syndrome with a significant prevalence that increases morbidity and mortality. There are some relevant factors that can show an increased risk of incidence of osteosarcopenia. Aim We aimed to consider the association of bone turnover markers such as Osteocalcin (OC), C-terminal cross-linked telopeptide (CTX), Tartrate Resistant acid Phosphatase (TRAP), Bone Alkaline Phosphatase (BALP) and also other factors like vitamin D, calcium, phosphorous, and ALP with osteosarcopenia in elderly. Methods We carried out a cross-sectional study on a random sample including 400 elder participants of Bushehr Elderly Health (BEH) study, in Iran. Osteopenia/ osteoporosis was defined as a T-score ≤ -1.0 standard deviation below the mean values of a young healthy adult. We defined sarcopenia as low muscle strength (handgrip strength<26 kg for men and <18 kg for women) with reduced skeletal muscle mass [Skeletal muscle index (SMI) < 7.0 kg/m2 for male and <5.4 kg/m2 for female]. Osteosarcopenia was considered as the presence of both osteopenia/osteoporosis and sarcopenia. We estimated the age-standardized prevalence of osteosarcopenia for men and women, separately. We used multivariable logistic regression to address the factors associated with osteosarcopenia. Results The results showed that there was a statistically significant difference in OC), CTX, TRAP were between the osteosarcopenia (-) and osteosarcopenia (+) groups. No statistically significant difference was observed in BALP, vitamin D, calcium, phosphorous, and ALP between the compared groups. In the multivariable logistic regression model, OC and CTX were associated with increased likelihood of osteosarcopenia [adjusted OR= 1.023(1.002-1.045 for OC, 4.363(1.389-15.474 for CTX)]. Furthermore, TRAP increases the odds of osteosarcopenia in crude model [OR= 1.333 (1.070- 1.660)]. Conclusions We observed the association between bone turnover markers particularly OC, CTX and osteosarcopenia. Given the rapid growth of the aging population, we should focus on geriatric diseases such as musculoskeletal disorders. Bone turnover markers maybe improve the early diagnosis, screening and assess the response to therapies in people with osteosarcopenia.Maryam FathiRamin HeshmatMehdi EbrahimiAhmad SalimzadehAfshin OstovarAli FathiFarideh RaziIraj NabipourMaryam MoghaddassiGita ShafieeBMCarticleOsteosarcopeniaBone turnover markersOlder peopleGeriatricsRC952-954.6ENBMC Geriatrics, Vol 21, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Osteosarcopenia Bone turnover markers Older people Geriatrics RC952-954.6
spellingShingle	Osteosarcopenia Bone turnover markers Older people Geriatrics RC952-954.6 Maryam Fathi Ramin Heshmat Mehdi Ebrahimi Ahmad Salimzadeh Afshin Ostovar Ali Fathi Farideh Razi Iraj Nabipour Maryam Moghaddassi Gita Shafiee Association between biomarkers of bone health and osteosarcopenia among Iranian older people: The Bushehr Elderly Health (BEH) program
description	Abstract Background Osteosarcopenia is referred to as co-incidence of osteoporosis/osteopenia and sarcopenia which is defined as a geriatric syndrome with a significant prevalence that increases morbidity and mortality. There are some relevant factors that can show an increased risk of incidence of osteosarcopenia. Aim We aimed to consider the association of bone turnover markers such as Osteocalcin (OC), C-terminal cross-linked telopeptide (CTX), Tartrate Resistant acid Phosphatase (TRAP), Bone Alkaline Phosphatase (BALP) and also other factors like vitamin D, calcium, phosphorous, and ALP with osteosarcopenia in elderly. Methods We carried out a cross-sectional study on a random sample including 400 elder participants of Bushehr Elderly Health (BEH) study, in Iran. Osteopenia/ osteoporosis was defined as a T-score ≤ -1.0 standard deviation below the mean values of a young healthy adult. We defined sarcopenia as low muscle strength (handgrip strength<26 kg for men and <18 kg for women) with reduced skeletal muscle mass [Skeletal muscle index (SMI) < 7.0 kg/m2 for male and <5.4 kg/m2 for female]. Osteosarcopenia was considered as the presence of both osteopenia/osteoporosis and sarcopenia. We estimated the age-standardized prevalence of osteosarcopenia for men and women, separately. We used multivariable logistic regression to address the factors associated with osteosarcopenia. Results The results showed that there was a statistically significant difference in OC), CTX, TRAP were between the osteosarcopenia (-) and osteosarcopenia (+) groups. No statistically significant difference was observed in BALP, vitamin D, calcium, phosphorous, and ALP between the compared groups. In the multivariable logistic regression model, OC and CTX were associated with increased likelihood of osteosarcopenia [adjusted OR= 1.023(1.002-1.045 for OC, 4.363(1.389-15.474 for CTX)]. Furthermore, TRAP increases the odds of osteosarcopenia in crude model [OR= 1.333 (1.070- 1.660)]. Conclusions We observed the association between bone turnover markers particularly OC, CTX and osteosarcopenia. Given the rapid growth of the aging population, we should focus on geriatric diseases such as musculoskeletal disorders. Bone turnover markers maybe improve the early diagnosis, screening and assess the response to therapies in people with osteosarcopenia.
format	article
author	Maryam Fathi Ramin Heshmat Mehdi Ebrahimi Ahmad Salimzadeh Afshin Ostovar Ali Fathi Farideh Razi Iraj Nabipour Maryam Moghaddassi Gita Shafiee
author_facet	Maryam Fathi Ramin Heshmat Mehdi Ebrahimi Ahmad Salimzadeh Afshin Ostovar Ali Fathi Farideh Razi Iraj Nabipour Maryam Moghaddassi Gita Shafiee
author_sort	Maryam Fathi
title	Association between biomarkers of bone health and osteosarcopenia among Iranian older people: The Bushehr Elderly Health (BEH) program
title_short	Association between biomarkers of bone health and osteosarcopenia among Iranian older people: The Bushehr Elderly Health (BEH) program
title_full	Association between biomarkers of bone health and osteosarcopenia among Iranian older people: The Bushehr Elderly Health (BEH) program
title_fullStr	Association between biomarkers of bone health and osteosarcopenia among Iranian older people: The Bushehr Elderly Health (BEH) program
title_full_unstemmed	Association between biomarkers of bone health and osteosarcopenia among Iranian older people: The Bushehr Elderly Health (BEH) program
title_sort	association between biomarkers of bone health and osteosarcopenia among iranian older people: the bushehr elderly health (beh) program
publisher	BMC
publishDate	2021
url	https://doaj.org/article/9f8b7a296435474c9de36ec6d216bad8
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Association between biomarkers of bone health and osteosarcopenia among Iranian older people: The Bushehr Elderly Health (BEH) program

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