3D genome organization contributes to genome instability at fragile sites

Common fragile sites are regions susceptible to replication stress and are prone to chromosomal instability. Here, the authors, by analyzing the contribution of 3D chromatin organization, identify and characterize a fragility signature and precisely map these fragility regions.

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Autores principales:	Dan Sarni, Takayo Sasaki, Michal Irony Tur-Sinai, Karin Miron, Juan Carlos Rivera-Mulia, Brian Magnuson, Mats Ljungman, David M. Gilbert, Batsheva Kerem
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/9f8f6dfda64441a5ae8eee34d19b3fb8
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spelling	oai:doaj.org-article:9f8f6dfda64441a5ae8eee34d19b3fb82021-12-02T17:01:15Z3D genome organization contributes to genome instability at fragile sites10.1038/s41467-020-17448-22041-1723https://doaj.org/article/9f8f6dfda64441a5ae8eee34d19b3fb82020-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17448-2https://doaj.org/toc/2041-1723Common fragile sites are regions susceptible to replication stress and are prone to chromosomal instability. Here, the authors, by analyzing the contribution of 3D chromatin organization, identify and characterize a fragility signature and precisely map these fragility regions.Dan SarniTakayo SasakiMichal Irony Tur-SinaiKarin MironJuan Carlos Rivera-MuliaBrian MagnusonMats LjungmanDavid M. GilbertBatsheva KeremNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Dan Sarni Takayo Sasaki Michal Irony Tur-Sinai Karin Miron Juan Carlos Rivera-Mulia Brian Magnuson Mats Ljungman David M. Gilbert Batsheva Kerem 3D genome organization contributes to genome instability at fragile sites
description	Common fragile sites are regions susceptible to replication stress and are prone to chromosomal instability. Here, the authors, by analyzing the contribution of 3D chromatin organization, identify and characterize a fragility signature and precisely map these fragility regions.
format	article
author	Dan Sarni Takayo Sasaki Michal Irony Tur-Sinai Karin Miron Juan Carlos Rivera-Mulia Brian Magnuson Mats Ljungman David M. Gilbert Batsheva Kerem
author_facet	Dan Sarni Takayo Sasaki Michal Irony Tur-Sinai Karin Miron Juan Carlos Rivera-Mulia Brian Magnuson Mats Ljungman David M. Gilbert Batsheva Kerem
author_sort	Dan Sarni
title	3D genome organization contributes to genome instability at fragile sites
title_short	3D genome organization contributes to genome instability at fragile sites
title_full	3D genome organization contributes to genome instability at fragile sites
title_fullStr	3D genome organization contributes to genome instability at fragile sites
title_full_unstemmed	3D genome organization contributes to genome instability at fragile sites
title_sort	3d genome organization contributes to genome instability at fragile sites
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/9f8f6dfda64441a5ae8eee34d19b3fb8
work_keys_str_mv	AT dansarni 3dgenomeorganizationcontributestogenomeinstabilityatfragilesites AT takayosasaki 3dgenomeorganizationcontributestogenomeinstabilityatfragilesites AT michalironytursinai 3dgenomeorganizationcontributestogenomeinstabilityatfragilesites AT karinmiron 3dgenomeorganizationcontributestogenomeinstabilityatfragilesites AT juancarlosriveramulia 3dgenomeorganizationcontributestogenomeinstabilityatfragilesites AT brianmagnuson 3dgenomeorganizationcontributestogenomeinstabilityatfragilesites AT matsljungman 3dgenomeorganizationcontributestogenomeinstabilityatfragilesites AT davidmgilbert 3dgenomeorganizationcontributestogenomeinstabilityatfragilesites AT batshevakerem 3dgenomeorganizationcontributestogenomeinstabilityatfragilesites
_version_	1718382226972868608

3D genome organization contributes to genome instability at fragile sites

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