Low dose of zearalenone elevated colon cancer cell growth through G protein-coupled estrogenic receptor

Abstract Colon cancer is one of the leading causes of cancer death worldwide. It is widely believed that environmental factors contribute to colon cancer development. Zearalenone (ZEA) is non-steroidal estrogenic mycotoxin that is widely found in the human diet and animal feeds. Most cancer studies...

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Autores principales:	Emily Kwun Kwan Lo, Jetty Chung-Yung Lee, Paul C. Turner, Hani El-Nezami
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/9f908ae356d54344bc371d95396631b9
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spelling	oai:doaj.org-article:9f908ae356d54344bc371d95396631b92021-12-02T14:23:32ZLow dose of zearalenone elevated colon cancer cell growth through G protein-coupled estrogenic receptor10.1038/s41598-021-86788-w2045-2322https://doaj.org/article/9f908ae356d54344bc371d95396631b92021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-86788-whttps://doaj.org/toc/2045-2322Abstract Colon cancer is one of the leading causes of cancer death worldwide. It is widely believed that environmental factors contribute to colon cancer development. Zearalenone (ZEA) is non-steroidal estrogenic mycotoxin that is widely found in the human diet and animal feeds. Most cancer studies of ZEA focused on estrogen sensitive cancers, while few focused on other types, such as colon cancer; despite the gastrointestinal tract being the first barrier exposed to food contaminants. This study investigated the stimulatory effects of ZEA on colon cancer cell lines and their underlying molecular mechanisms. ZEA promoted anchorage independent cell growth and cell cycle progression through promoting G1-to-S phase transition. Proliferative marker, cyclin D1 and Ki67 were found to be upregulated upon ZEA treatment. G protein-coupled estrogenic receptor 1 (GPER) protein expression was promoted upon ZEA treatment suggesting the involvement of GPER. The growth promoting effect mediated through GPER were suppressed by its antagonist G15. ZEA were found to promote the downstream parallel pathway, MAPK signaling pathway and Hippo pathway effector YAP1. Altogether, our observations suggest a novel mechanism by which ZEA could promote cancer growth and provide a new perspective on the carcinogenicity of ZEA.Emily Kwun Kwan LoJetty Chung-Yung LeePaul C. TurnerHani El-NezamiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Emily Kwun Kwan Lo Jetty Chung-Yung Lee Paul C. Turner Hani El-Nezami Low dose of zearalenone elevated colon cancer cell growth through G protein-coupled estrogenic receptor
description	Abstract Colon cancer is one of the leading causes of cancer death worldwide. It is widely believed that environmental factors contribute to colon cancer development. Zearalenone (ZEA) is non-steroidal estrogenic mycotoxin that is widely found in the human diet and animal feeds. Most cancer studies of ZEA focused on estrogen sensitive cancers, while few focused on other types, such as colon cancer; despite the gastrointestinal tract being the first barrier exposed to food contaminants. This study investigated the stimulatory effects of ZEA on colon cancer cell lines and their underlying molecular mechanisms. ZEA promoted anchorage independent cell growth and cell cycle progression through promoting G1-to-S phase transition. Proliferative marker, cyclin D1 and Ki67 were found to be upregulated upon ZEA treatment. G protein-coupled estrogenic receptor 1 (GPER) protein expression was promoted upon ZEA treatment suggesting the involvement of GPER. The growth promoting effect mediated through GPER were suppressed by its antagonist G15. ZEA were found to promote the downstream parallel pathway, MAPK signaling pathway and Hippo pathway effector YAP1. Altogether, our observations suggest a novel mechanism by which ZEA could promote cancer growth and provide a new perspective on the carcinogenicity of ZEA.
format	article
author	Emily Kwun Kwan Lo Jetty Chung-Yung Lee Paul C. Turner Hani El-Nezami
author_facet	Emily Kwun Kwan Lo Jetty Chung-Yung Lee Paul C. Turner Hani El-Nezami
author_sort	Emily Kwun Kwan Lo
title	Low dose of zearalenone elevated colon cancer cell growth through G protein-coupled estrogenic receptor
title_short	Low dose of zearalenone elevated colon cancer cell growth through G protein-coupled estrogenic receptor
title_full	Low dose of zearalenone elevated colon cancer cell growth through G protein-coupled estrogenic receptor
title_fullStr	Low dose of zearalenone elevated colon cancer cell growth through G protein-coupled estrogenic receptor
title_full_unstemmed	Low dose of zearalenone elevated colon cancer cell growth through G protein-coupled estrogenic receptor
title_sort	low dose of zearalenone elevated colon cancer cell growth through g protein-coupled estrogenic receptor
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/9f908ae356d54344bc371d95396631b9
work_keys_str_mv	AT emilykwunkwanlo lowdoseofzearalenoneelevatedcoloncancercellgrowththroughgproteincoupledestrogenicreceptor AT jettychungyunglee lowdoseofzearalenoneelevatedcoloncancercellgrowththroughgproteincoupledestrogenicreceptor AT paulcturner lowdoseofzearalenoneelevatedcoloncancercellgrowththroughgproteincoupledestrogenicreceptor AT hanielnezami lowdoseofzearalenoneelevatedcoloncancercellgrowththroughgproteincoupledestrogenicreceptor
_version_	1718391441832542208

Low dose of zearalenone elevated colon cancer cell growth through G protein-coupled estrogenic receptor

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